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OPENSEQ.org
FADL - Long-chain fatty acid transport protein
UniProt: P10384 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10280
Length: 446 (425)
Sequences: 1042
Seq/Len: 2.45
FADL
Paralog alert: 0.21 [within 20: 0.05] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
63_T 158_A 3.987 1.00
412_V 436_W 3.851 1.00
370_I 392_F 3.676 1.00
414_Y 436_W 3.51 1.00
318_L 350_Y 3.359 1.00
406_A 442_F 3.286 1.00
298_E 322_S 3.265 1.00
312_W 356_T 3.094 1.00
173_A 230_W 2.95 1.00
394_L 416_H 2.825 1.00
407_S 443_N 2.786 1.00
324_S 348_D 2.772 1.00
246_N 306_N 2.743 1.00
165_W 240_Y 2.688 1.00
395_S 413_S 2.595 1.00
73_G 106_N 2.504 1.00
117_F 157_G 2.487 1.00
63_T 166_S 2.417 1.00
68_P 109_F 2.349 1.00
67_R 112_P 2.322 1.00
250_L 302_V 2.223 1.00
360_Y 366_F 2.216 1.00
364_W 398_T 2.177 1.00
367_R 409_D 2.168 1.00
165_W 238_I 2.161 1.00
54_N 61_L 2.059 1.00
174_V 258_I 2.043 0.99
410_V 440_T 2.037 0.99
233_G 256_V 2.004 0.99
55_V 122_S 1.985 0.99
318_L 352_I 1.971 0.99
123_I 153_L 1.964 0.99
300_W 320_Y 1.954 0.99
314_I 356_T 1.949 0.99
372_F 392_F 1.928 0.99
173_A 232_F 1.914 0.99
312_W 358_Y 1.907 0.99
305_Y 313_A 1.887 0.99
354_L 370_I 1.886 0.99
399_T 409_D 1.884 0.99
307_R 359_Y 1.847 0.99
161_L 167_F 1.828 0.99
164_A 240_Y 1.812 0.98
246_N 304_G 1.809 0.98
62_I 110_V 1.77 0.98
320_Y 350_Y 1.768 0.98
35_S 439_G 1.754 0.98
121_A 153_L 1.737 0.98
361_D 364_W 1.722 0.98
360_Y 364_W 1.665 0.97
62_I 158_A 1.653 0.97
367_R 399_T 1.631 0.97
68_P 111_A 1.578 0.96
359_Y 365_T 1.56 0.95
326_F 344_E 1.559 0.95
322_S 325_Q 1.555 0.95
399_T 407_S 1.551 0.95
108_H 122_S 1.55 0.95
119_W 157_G 1.547 0.95
416_H 436_W 1.546 0.95
116_Q 159_Y 1.528 0.94
241_E 247_R 1.524 0.94
227_G 260_F 1.511 0.94
121_A 155_L 1.486 0.93
234_W 254_S 1.484 0.93
255_E 295_N 1.477 0.93
154_N 235_N 1.472 0.93
76_Y 101_T 1.463 0.93
61_L 65_F 1.444 0.92
235_N 253_R 1.423 0.91
67_R 110_V 1.408 0.91
160_R 241_E 1.401 0.90
63_T 160_R 1.398 0.90
248_Y 302_V 1.395 0.90
77_I 104_V 1.391 0.90
62_I 156_S 1.383 0.90
406_A 444_Y 1.369 0.89
229_Q 260_F 1.354 0.88
61_L 239_L 1.352 0.88
309_D 312_W 1.35 0.88
64_M 241_E 1.348 0.88
175_Y 230_W 1.347 0.88
176_A 258_I 1.341 0.88
170_G 235_N 1.337 0.87
64_M 247_R 1.334 0.87
245_N 306_N 1.334 0.87
64_M 239_L 1.332 0.87
363_N 400_Y 1.329 0.87
117_F 159_Y 1.325 0.87
258_I 296_L 1.324 0.87
27_G 346_F 1.297 0.85
402_F 408_V 1.295 0.85
56_S 126_N 1.292 0.85
152_N 172_N 1.286 0.84
308_V 314_I 1.283 0.84
141_S 220_T 1.281 0.84
46_G 303_S 1.274 0.84
40_R 357_T 1.265 0.83
242_L 248_Y 1.26 0.83
296_L 329_L 1.245 0.82
259_D 293_T 1.242 0.81
67_R 405_D 1.238 0.81
123_I 151_M 1.226 0.80
308_V 312_W 1.211 0.79
313_A 357_T 1.211 0.79
365_T 399_T 1.202 0.78
7_F 13_A 1.194 0.78
71_S 443_N 1.193 0.78
49_A 54_N 1.191 0.78
243_D 246_N 1.183 0.77
11_A 21_T 1.178 0.77
161_L 165_W 1.174 0.76
301_E 317_S 1.171 0.76
398_T 410_V 1.169 0.76
352_I 374_D 1.168 0.76
401_A 445_A 1.166 0.75
40_R 315_H 1.156 0.75
421_K 430_E 1.154 0.74
113_I 117_F 1.151 0.74
317_S 353_A 1.15 0.74
411_G 439_G 1.149 0.74
146_T 385_S 1.148 0.74
368_T 396_A 1.147 0.74
250_L 300_W 1.146 0.74
112_P 118_G 1.143 0.73
47_A 305_Y 1.143 0.73
240_Y 348_D 1.14 0.73
3_Q 6_L 1.139 0.73
371_A 393_W 1.138 0.73
69_T 110_V 1.133 0.72
257_K 295_N 1.131 0.72
40_R 45_E 1.129 0.72
63_T 110_V 1.128 0.72
321_T 374_D 1.127 0.72
70_F 109_F 1.125 0.72
394_L 414_Y 1.124 0.72
412_V 438_F 1.124 0.72
236_A 254_S 1.121 0.71
41_A 371_A 1.121 0.71
405_D 444_Y 1.121 0.71
321_T 371_A 1.12 0.71
19_I 23_A 1.117 0.71
396_A 412_V 1.113 0.71
231_G 258_I 1.109 0.70
74_A 103_W 1.108 0.70
349_A 374_D 1.108 0.70
55_V 61_L 1.104 0.70
321_T 351_R 1.101 0.69
63_T 118_G 1.101 0.69
75_V 439_G 1.098 0.69
357_T 367_R 1.093 0.69
8_T 12_L 1.09 0.68
75_V 437_L 1.088 0.68
298_E 325_Q 1.082 0.67
118_G 158_A 1.08 0.67
51_D 71_S 1.078 0.67
370_I 395_S 1.075 0.67
30_L 129_L 1.073 0.66
166_S 375_S 1.07 0.66
174_V 296_L 1.069 0.66
78_D 438_F 1.067 0.66
149_E 177_R 1.063 0.65
57_R 126_N 1.058 0.65
48_I 51_D 1.058 0.65
51_D 61_L 1.057 0.65
249_A 366_F 1.057 0.65
357_T 365_T 1.057 0.65
37_G 42_Y 1.055 0.65
4_K 8_T 1.052 0.64
1_M 4_K 1.051 0.64
238_I 250_L 1.042 0.63
323_W 373_D 1.039 0.63
405_D 445_A 1.037 0.63
176_A 260_F 1.035 0.62
62_I 118_G 1.035 0.62
26_A 346_F 1.022 0.61
154_N 170_G 1.022 0.61
49_A 61_L 1.019 0.61
75_V 106_N 1.018 0.60
36_S 357_T 1.016 0.60
326_F 383_S 1.016 0.60
315_H 357_T 1.013 0.60
13_A 19_I 1.01 0.60
41_A 395_S 1.006 0.59
347_K 378_P 1.001 0.59
308_V 434_K 1 0.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pguA10.94391000.284Contact Map0.78
3bryA20.89911000.318Contact Map0.723
3bs0A20.89691000.323Contact Map0.75
3dwoX10.91261000.363Contact Map0.743
1i78A20.486599.70.822Contact Map0.292
3qraA10.347598.90.877Contact Map0.614
1ormA10.325198.80.882Contact Map0.26
1qjpA10.374498.70.887Contact Map0.605
2x27X10.423897.40.919Contact Map0.689
2k0lA10.403696.80.926Contact Map0.356
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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