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OPENSEQ.org
EMTA - Endo-type membrane-bound lytic murein transglycosylase A
UniProt: P0C960 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13897
Length: 203 (178)
Sequences: 411
Seq/Len: 2.31
EMTA
Paralog alert: 0.79 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
40_M 44_Q 2.307 1.00
169_N 183_N 2 0.99
46_A 115_S 2 0.99
31_V 35_R 1.96 0.99
90_R 101_E 1.838 0.98
57_I 118_A 1.834 0.98
134_D 139_Q 1.722 0.97
153_L 180_V 1.711 0.97
158_S 167_K 1.646 0.96
128_P 153_L 1.622 0.96
45_K 111_E 1.606 0.96
83_L 116_M 1.588 0.95
72_V 108_K 1.557 0.95
42_I 111_E 1.533 0.94
148_N 189_A 1.482 0.92
93_Y 102_P 1.472 0.92
122_N 126_T 1.455 0.92
129_L 157_F 1.452 0.91
61_I 80_L 1.447 0.91
55_Q 200_L 1.426 0.90
119_A 191_R 1.413 0.90
31_V 202_A 1.38 0.88
60_I 145_S 1.379 0.88
52_V 125_E 1.372 0.88
152_A 188_Q 1.372 0.88
171_L 183_N 1.358 0.87
154_L 157_F 1.349 0.87
92_V 116_M 1.341 0.86
106_E 112_R 1.335 0.86
39_W 67_G 1.326 0.86
76_N 101_E 1.317 0.85
100_G 154_L 1.285 0.83
75_S 84_K 1.279 0.83
148_N 190_P 1.271 0.82
35_R 202_A 1.27 0.82
43_S 67_G 1.268 0.82
169_N 177_L 1.268 0.82
43_S 114_I 1.266 0.82
50_W 115_S 1.262 0.82
47_G 118_A 1.253 0.81
60_I 121_L 1.252 0.81
148_N 184_H 1.248 0.81
194_Y 202_A 1.228 0.79
165_I 179_H 1.218 0.78
171_L 195_K 1.214 0.78
35_R 46_A 1.209 0.78
44_Q 54_P 1.206 0.77
77_A 107_L 1.2 0.77
101_E 163_K 1.187 0.76
88_S 147_A 1.169 0.74
43_S 58_T 1.157 0.73
152_A 155_R 1.15 0.72
38_Q 68_N 1.145 0.72
61_I 121_L 1.141 0.72
128_P 132_I 1.132 0.71
162_K 165_I 1.129 0.70
89_G 169_N 1.119 0.69
151_G 173_A 1.107 0.68
187_P 190_P 1.105 0.68
154_L 158_S 1.101 0.68
135_P 139_Q 1.092 0.67
112_R 116_M 1.092 0.67
89_G 123_I 1.087 0.66
157_F 174_D 1.079 0.65
131_G 154_L 1.077 0.65
76_N 144_V 1.076 0.65
29_A 202_A 1.073 0.65
152_A 186_A 1.073 0.65
97_G 118_A 1.071 0.64
91_D 193_I 1.07 0.64
58_T 62_A 1.065 0.64
141_A 150_A 1.064 0.64
76_N 84_K 1.06 0.63
80_L 119_A 1.051 0.62
190_P 202_A 1.049 0.62
134_D 203_M 1.048 0.62
131_G 165_I 1.044 0.62
56_L 135_P 1.041 0.61
52_V 122_N 1.037 0.61
67_G 128_P 1.037 0.61
45_K 170_D 1.03 0.60
77_A 82_Q 1.028 0.60
89_G 154_L 1.025 0.59
96_M 177_L 1.021 0.59
131_G 158_S 1.019 0.59
137_V 176_F 1.007 0.57
56_L 195_K 1.006 0.57
39_W 89_G 1.002 0.57
96_M 116_M 1.001 0.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3t21A211000.367Contact Map0.401
1qsaA10.90641000.473Contact Map0.499
4g9sA10.81281000.557Contact Map0.45
3gxrA40.8031000.559Contact Map0.514
3w6bA40.82761000.559Contact Map0.402
3bkhA10.91631000.565Contact Map0.4
1gbsA10.81281000.567Contact Map0.428
4fdyA20.7981000.627Contact Map0.489
4hpeA60.763599.90.63Contact Map0.403
1qusA10.93199.60.772Contact Map0.476
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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