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OPENSEQ.org

OSMC - Peroxiredoxin OsmC
UniProt: P0C0L2 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10680
Length: 143 (142)
Sequences: 1244
Seq/Len: 8.76

OSMC
Paralog alert: 0.25 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
110_D 113_T 3.826 1.00
111_A 115_D 3.447 1.00
115_D 119_Q 3.437 1.00
14_D 17_R 2.917 1.00
71_A 120_K 2.82 1.00
113_T 116_G 2.599 1.00
106_V 114_F 2.361 1.00
61_S 78_I 2.248 1.00
84_V 100_L 2.18 1.00
22_V 54_A 2.155 1.00
116_G 120_K 2.145 1.00
26_S 50_E 2.033 1.00
103_E 140_Q 2.016 1.00
95_I 127_V 2.01 1.00
8_Q 83_D 2.009 1.00
83_D 101_K 1.982 1.00
67_M 124_G 1.959 1.00
15_I 66_L 1.913 1.00
119_Q 123_A 1.913 1.00
85_S 96_T 1.899 1.00
101_K 138_D 1.87 1.00
82_A 102_S 1.8 1.00
61_S 80_T 1.768 1.00
101_K 136_T 1.724 1.00
103_E 138_D 1.638 1.00
10_H 81_T 1.592 1.00
36_F 40_F 1.571 1.00
21_T 31_Q 1.494 1.00
52_I 127_V 1.494 1.00
10_H 79_D 1.491 1.00
60_F 118_I 1.442 0.99
23_S 31_Q 1.433 0.99
118_I 139_Y 1.428 0.99
23_S 27_G 1.366 0.99
11_W 57_A 1.349 0.99
130_V 133_A 1.31 0.99
89_V 129_Q 1.309 0.99
71_A 116_G 1.304 0.99
56_H 100_L 1.296 0.99
66_L 70_E 1.295 0.99
83_D 103_E 1.29 0.98
73_F 113_T 1.288 0.98
8_Q 81_T 1.285 0.98
89_V 94_A 1.26 0.98
7_G 25_E 1.245 0.98
63_A 67_M 1.237 0.98
62_M 95_I 1.228 0.98
67_M 117_I 1.222 0.98
22_V 32_Q 1.209 0.97
24_T 46_T 1.207 0.97
9_A 24_T 1.198 0.97
52_I 131_L 1.187 0.97
11_W 22_V 1.183 0.97
109_I 113_T 1.18 0.97
21_T 33_P 1.176 0.97
6_K 83_D 1.174 0.97
28_V 45_G 1.172 0.97
97_K 134_E 1.169 0.97
8_Q 25_E 1.164 0.97
61_S 65_S 1.152 0.96
120_K 124_G 1.127 0.96
64_L 71_A 1.114 0.95
46_T 50_E 1.072 0.94
61_S 79_D 1.065 0.94
11_W 61_S 1.035 0.92
24_T 54_A 1.023 0.92
64_L 121_A 1.021 0.92
6_K 85_S 1.017 0.91
42_G 45_G 1.013 0.91
36_F 62_M 1.009 0.91
76_T 105_A 1.004 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1nyeA60.9931000.322Contact Map0.53
1qwiA40.9931000.35Contact Map0.529
1ukkA20.9791000.365Contact Map0.576
1uspA10.9511000.384Contact Map0.543
4mh4A20.93711000.386Contact Map0.678
1n2fA20.93711000.388Contact Map0.778
1zb9A20.9511000.397Contact Map0.783
3eerA10.94411000.411Contact Map0.507
2ql8A20.92311000.413Contact Map0.705
2bjoA20.90911000.422Contact Map0.791

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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