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OPENSEQ.org
TRKA - Trk system potassium uptake protein TrkA
UniProt: P0AGI8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11019
Length: 458 (454)
Sequences: 944
Seq/Len: 2.08
TRKA
Paralog alert: 0.04 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
236_M 298_V 3.758 1.00
160_A 203_V 3.516 1.00
315_A 328_V 3.495 1.00
282_G 289_L 3.151 1.00
188_I 203_V 2.778 1.00
171_L 185_V 2.739 1.00
385_A 428_I 2.621 1.00
252_E 277_T 2.601 1.00
36_L 47_V 2.591 1.00
6_L 52_G 2.59 1.00
59_R 64_D 2.525 1.00
240_G 270_L 2.521 1.00
238_V 301_F 2.466 1.00
264_Q 281_F 2.34 1.00
398_V 401_E 2.177 1.00
248_A 274_L 2.168 1.00
9_G 98_R 2.141 0.99
259_L 277_T 2.107 0.99
160_A 167_I 2.044 0.99
30_D 36_L 1.982 0.99
9_G 12_G 1.964 0.99
415_R 432_D 1.954 0.99
5_I 16_A 1.913 0.99
83_C 97_A 1.874 0.98
238_V 284_A 1.864 0.98
162_Y 205_A 1.85 0.98
69_L 82_A 1.841 0.98
2_K 25_D 1.835 0.98
137_I 300_L 1.835 0.98
168_G 204_E 1.808 0.98
413_V 426_L 1.79 0.98
237_L 248_A 1.77 0.97
400_D 425_N 1.726 0.97
160_A 164_G 1.71 0.97
168_G 205_A 1.701 0.96
289_L 293_E 1.699 0.96
400_D 424_D 1.635 0.95
170_A 202_I 1.634 0.95
167_I 203_V 1.63 0.95
362_V 434_V 1.628 0.95
236_M 301_F 1.576 0.94
22_E 363_R 1.571 0.94
153_V 412_A 1.56 0.94
236_M 293_E 1.559 0.93
28_V 45_L 1.558 0.93
4_I 63_A 1.557 0.93
30_D 47_V 1.549 0.93
153_V 414_V 1.547 0.93
3_I 26_I 1.544 0.93
389_E 430_Q 1.528 0.93
261_E 267_A 1.498 0.92
69_L 86_A 1.493 0.91
291_A 321_M 1.492 0.91
5_I 26_I 1.478 0.91
248_A 259_L 1.477 0.91
295_I 321_M 1.468 0.90
50_G 57_V 1.448 0.90
199_G 424_D 1.438 0.89
305_T 311_N 1.433 0.89
190_R 207_D 1.43 0.89
16_A 43_F 1.419 0.88
260_I 289_L 1.418 0.88
244_G 304_V 1.405 0.88
267_A 270_L 1.393 0.87
87_Y 95_R 1.393 0.87
66_A 348_I 1.385 0.87
33_G 49_Q 1.384 0.87
32_N 35_R 1.382 0.87
9_G 73_T 1.379 0.86
186_A 411_G 1.376 0.86
61_A 66_A 1.368 0.86
295_I 323_A 1.364 0.86
20_V 45_L 1.356 0.85
76_D 308_D 1.351 0.85
11_V 98_R 1.351 0.85
384_V 397_R 1.35 0.85
12_G 98_R 1.346 0.85
170_A 173_T 1.335 0.84
167_I 205_A 1.332 0.84
39_L 45_L 1.329 0.84
27_T 96_I 1.325 0.83
56_R 60_E 1.309 0.82
84_Q 118_P 1.306 0.82
233_K 325_K 1.301 0.82
241_G 244_G 1.299 0.82
80_M 119_I 1.297 0.81
157_V 210_F 1.287 0.81
185_V 347_A 1.286 0.81
4_I 69_L 1.284 0.81
362_V 445_T 1.277 0.80
381_I 436_M 1.276 0.80
308_D 350_P 1.266 0.79
453_P 457_F 1.265 0.79
83_C 123_I 1.251 0.78
88_S 116_A 1.251 0.78
4_I 66_A 1.246 0.78
83_C 95_R 1.246 0.78
105_V 128_L 1.245 0.78
34_E 188_I 1.244 0.78
13_G 39_L 1.229 0.76
12_G 73_T 1.226 0.76
397_R 401_E 1.219 0.76
410_I 413_V 1.213 0.75
5_I 272_E 1.213 0.75
5_I 428_I 1.193 0.73
63_A 92_T 1.191 0.73
280_F 289_L 1.188 0.73
197_P 424_D 1.187 0.73
26_I 45_L 1.183 0.72
241_G 305_T 1.182 0.72
147_N 260_I 1.173 0.72
363_R 379_E 1.169 0.71
227_R 304_V 1.167 0.71
63_A 90_F 1.165 0.71
158_V 211_F 1.161 0.70
259_L 265_Q 1.158 0.70
301_F 318_A 1.157 0.70
147_N 151_G 1.154 0.70
157_V 208_E 1.15 0.69
29_V 48_V 1.149 0.69
251_L 257_V 1.149 0.69
267_A 293_E 1.146 0.69
378_A 437_F 1.144 0.69
29_V 57_V 1.139 0.68
261_E 350_P 1.138 0.68
12_G 71_A 1.138 0.68
39_L 43_F 1.134 0.68
244_G 248_A 1.133 0.68
399_I 402_I 1.133 0.68
44_D 248_A 1.129 0.67
15_L 72_V 1.127 0.67
185_V 312_I 1.122 0.67
235_I 255_Y 1.12 0.66
258_K 293_E 1.118 0.66
266_R 269_E 1.115 0.66
115_D 230_K 1.114 0.66
182_D 217_H 1.111 0.65
259_L 279_V 1.11 0.65
87_Y 120_D 1.11 0.65
211_F 316_M 1.108 0.65
66_A 241_G 1.106 0.65
12_G 30_D 1.106 0.65
309_E 335_Y 1.105 0.65
324_K 367_I 1.105 0.65
185_V 217_H 1.105 0.65
186_A 409_I 1.103 0.65
173_T 236_M 1.101 0.64
264_Q 268_A 1.1 0.64
8_A 16_A 1.096 0.64
80_M 118_P 1.092 0.64
33_G 295_I 1.089 0.63
173_T 176_E 1.089 0.63
196_R 199_G 1.087 0.63
117_V 411_G 1.084 0.63
54_H 101_S 1.078 0.62
241_G 329_L 1.076 0.62
160_A 177_H 1.073 0.62
56_R 436_M 1.073 0.62
453_P 456_F 1.07 0.61
63_A 69_L 1.068 0.61
304_V 329_L 1.068 0.61
396_G 429_E 1.067 0.61
249_R 291_A 1.066 0.61
290_L 295_I 1.065 0.61
328_V 332_R 1.062 0.60
423_N 426_L 1.061 0.60
410_I 436_M 1.056 0.60
169_N 173_T 1.053 0.59
385_A 395_V 1.051 0.59
131_D 250_R 1.05 0.59
87_Y 91_N 1.048 0.59
167_I 204_E 1.047 0.59
100_R 126_E 1.046 0.59
84_Q 88_S 1.046 0.59
269_E 273_K 1.044 0.58
244_G 447_V 1.043 0.58
26_I 341_G 1.043 0.58
51_H 171_L 1.041 0.58
17_E 288_E 1.039 0.58
285_S 310_A 1.036 0.57
51_H 157_V 1.034 0.57
214_A 217_H 1.033 0.57
241_G 282_G 1.033 0.57
129_V 348_I 1.032 0.57
13_G 43_F 1.031 0.57
285_S 367_I 1.03 0.57
8_A 405_P 1.028 0.57
319_K 322_G 1.025 0.56
69_L 236_M 1.025 0.56
17_E 117_V 1.022 0.56
142_A 221_V 1.021 0.56
295_I 447_V 1.018 0.55
249_R 288_E 1.014 0.55
409_I 422_A 1.013 0.55
304_V 315_A 1.012 0.55
313_M 351_Q 1.009 0.54
184_R 424_D 1.006 0.54
415_R 429_E 1.005 0.54
188_I 201_T 1.003 0.54
383_A 436_M 1.002 0.54
252_E 276_N 1 0.53
154_S 215_S 1 0.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4g65A20.98911000.295Contact Map0.587
4gx0A40.93451000.358Contact Map0.516
4hpfA20.98911000.502Contact Map0.484
3nafA10.97161000.532Contact Map0.48
3mt5A10.96721000.574Contact Map0.466
2aefA20.47821000.687Contact Map0.562
1lnqA80.46941000.696Contact Map0.607
3l4bC40.4761000.7Contact Map0.492
4j91A40.46721000.741Contact Map0.572
1id1A20.32199.90.815Contact Map0.6
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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