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OPENSEQ.org
TESB - Acyl-CoA thioesterase 2
UniProt: P0AGG2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10995
Length: 286 (283)
Sequences: 1281
Seq/Len: 4.53
TESB
Paralog alert: 0.23 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
267_T 271_V 4.68 1.00
20_G 80_T 4.053 1.00
34_V 74_I 3.738 1.00
243_E 268_Q 3.612 1.00
72_K 97_N 2.983 1.00
126_A 129_G 2.889 1.00
128_D 268_Q 2.829 1.00
236_H 275_S 2.716 1.00
55_R 88_S 2.678 1.00
79_E 93_A 2.66 1.00
15_E 23_R 2.571 1.00
208_L 280_G 2.542 1.00
245_L 273_V 2.474 1.00
179_Q 248_S 2.411 1.00
23_R 75_I 2.343 1.00
48_K 193_R 2.333 1.00
66_R 99_K 2.255 1.00
237_R 253_S 2.183 1.00
182_I 265_F 2.09 1.00
21_L 75_I 2.085 1.00
13_N 49_E 2.07 1.00
211_A 259_G 1.979 1.00
207_F 261_V 1.93 1.00
16_K 19_E 1.927 1.00
40_V 200_G 1.925 1.00
18_E 75_I 1.903 1.00
117_H 251_S 1.892 1.00
61_H 230_D 1.884 1.00
199_L 274_A 1.876 1.00
83_D 90_R 1.864 1.00
263_G 276_T 1.803 1.00
74_I 94_A 1.793 1.00
44_L 57_V 1.768 1.00
81_L 89_A 1.753 1.00
45_Y 49_E 1.736 0.99
68_G 101_I 1.703 0.99
260_F 275_S 1.637 0.99
22_F 50_T 1.594 0.99
63_Y 230_D 1.57 0.99
181_W 246_L 1.556 0.99
17_I 23_R 1.554 0.99
47_A 106_A 1.544 0.99
62_S 102_F 1.537 0.98
17_I 21_L 1.531 0.98
195_H 240_N 1.517 0.98
17_I 75_I 1.513 0.98
18_E 95_I 1.509 0.98
190_D 240_N 1.506 0.98
18_E 21_L 1.504 0.98
176_P 214_P 1.493 0.98
183_R 244_W 1.49 0.98
250_E 262_R 1.46 0.98
50_T 90_R 1.457 0.98
247_Y 263_G 1.456 0.98
200_G 233_M 1.437 0.97
76_Y 94_A 1.43 0.97
77_D 95_I 1.419 0.97
196_Q 238_P 1.399 0.97
159_E 183_R 1.383 0.96
57_V 196_Q 1.38 0.96
14_L 46_A 1.374 0.96
40_V 62_S 1.374 0.96
113_A 116_E 1.354 0.96
211_A 214_P 1.321 0.95
93_A 103_Y 1.316 0.95
51_V 90_R 1.316 0.95
13_N 45_Y 1.311 0.95
16_K 22_F 1.309 0.95
15_E 21_L 1.305 0.95
127_P 244_W 1.304 0.95
50_T 83_D 1.297 0.94
248_S 264_E 1.287 0.94
180_V 206_N 1.28 0.94
262_R 275_S 1.275 0.94
127_P 181_W 1.269 0.94
132_S 135_Q 1.269 0.94
204_D 228_T 1.265 0.93
211_A 282_M 1.264 0.93
203_S 231_H 1.258 0.93
78_V 90_R 1.255 0.93
81_L 100_P 1.254 0.93
117_H 215_H 1.249 0.93
42_Q 76_Y 1.247 0.93
190_D 195_H 1.235 0.92
188_V 195_H 1.232 0.92
160_V 205_L 1.203 0.91
21_L 77_D 1.199 0.91
245_L 265_F 1.197 0.91
37_G 204_D 1.195 0.91
45_Y 197_Y 1.188 0.90
20_G 77_D 1.185 0.90
43_A 92_V 1.148 0.88
95_I 98_G 1.131 0.87
117_H 252_T 1.125 0.87
67_P 227_A 1.123 0.87
127_P 268_Q 1.106 0.85
35_F 204_D 1.099 0.85
16_K 49_E 1.093 0.85
246_L 251_S 1.087 0.84
47_A 90_R 1.086 0.84
24_G 76_Y 1.08 0.84
47_A 92_V 1.068 0.83
93_A 105_T 1.067 0.83
125_P 130_L 1.066 0.82
35_F 205_L 1.063 0.82
182_I 202_A 1.059 0.82
240_N 243_E 1.059 0.82
247_Y 276_T 1.053 0.81
47_A 108_F 1.053 0.81
69_D 72_K 1.048 0.81
228_T 232_S 1.048 0.81
195_H 241_L 1.045 0.81
6_K 10_T 1.043 0.81
59_S 230_D 1.042 0.80
190_D 242_N 1.038 0.80
126_A 268_Q 1.033 0.80
80_T 83_D 1.032 0.80
211_A 261_V 1.03 0.79
9_L 13_N 1.026 0.79
124_A 246_L 1.024 0.79
48_K 196_Q 1.021 0.79
34_V 68_G 1.017 0.78
86_S 283_R 1.015 0.78
41_G 156_R 1.013 0.78
33_Q 67_P 1.011 0.78
50_T 78_V 1.008 0.77
188_V 241_L 1.007 0.77
231_H 279_E 1.006 0.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1c8uA20.99651000.126Contact Map0.771
3rd7A20.9721000.152Contact Map0.746
3u0aA20.96151000.164Contact Map0.768
3rqbA20.90561000.262Contact Map0.647
3cjyA10.87761000.312Contact Map0.554
3bbjA20.91961000.344Contact Map0.603
1tbuA40.39161000.613Contact Map0.732
1wluA10.45198.30.863Contact Map0.548
3b7kA30.97298.30.864Contact Map0.541
2gvhA30.832298.20.868Contact Map0.483
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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