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OPENSEQ.org
SUCD - Succinyl-CoA ligase [ADP-forming] subunit alpha
UniProt: P0AGE9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10982
Length: 289 (289)
Sequences: 2468
Seq/Len: 8.54
SUCD
Paralog alert: 0.55 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
147_K 202_E 5.271 1.00
93_I 117_V 2.957 1.00
259_A 273_T 2.888 1.00
56_T 59_E 2.586 1.00
266_L 271_V 2.523 1.00
78_C 100_I 2.514 1.00
163_K 167_D 2.491 1.00
83_L 111_K 2.47 1.00
55_N 59_E 2.428 1.00
47_T 50_G 2.406 1.00
26_E 30_A 2.4 1.00
274_V 283_A 2.331 1.00
204_I 226_V 2.307 1.00
263_F 273_T 2.249 1.00
232_G 266_L 2.248 1.00
86_I 115_A 2.247 1.00
193_E 197_K 2.158 1.00
67_T 91_K 2.155 1.00
58_R 87_D 2.146 1.00
213_S 217_E 2.14 1.00
262_K 266_L 2.101 1.00
7_K 132_E 2.092 1.00
173_S 201_T 2.048 1.00
186_S 191_I 2.034 1.00
198_D 201_T 2.009 1.00
205_V 280_I 1.999 1.00
11_V 33_T 1.984 1.00
58_R 84_E 1.955 1.00
60_A 66_A 1.95 1.00
68_A 135_I 1.942 1.00
220_A 224_E 1.913 1.00
176_V 191_I 1.912 1.00
112_L 119_M 1.908 1.00
203_A 284_L 1.887 1.00
13_C 35_M 1.884 1.00
258_T 261_E 1.856 1.00
16_F 25_S 1.817 1.00
73_V 81_S 1.783 1.00
129_T 132_E 1.776 1.00
131_G 145_P 1.772 1.00
37_G 54_F 1.727 1.00
196_E 227_T 1.725 1.00
85_A 90_I 1.724 1.00
29_I 51_L 1.716 1.00
148_V 203_A 1.704 1.00
118_R 185_G 1.702 1.00
73_V 77_F 1.679 1.00
148_V 284_L 1.655 1.00
118_R 186_S 1.628 1.00
265_A 269_A 1.628 1.00
101_P 105_M 1.589 1.00
192_L 204_I 1.588 1.00
82_I 93_I 1.565 1.00
79_K 107_T 1.562 1.00
264_A 268_A 1.554 1.00
83_L 107_T 1.534 1.00
237_V 275_R 1.527 1.00
44_G 55_N 1.525 1.00
4_L 194_M 1.517 1.00
40_T 44_G 1.515 1.00
69_S 85_A 1.483 1.00
54_F 64_T 1.481 1.00
279_D 282_E 1.478 1.00
95_T 119_M 1.468 0.99
267_E 275_R 1.468 0.99
39_V 60_A 1.467 0.99
145_P 200_Q 1.465 0.99
40_T 55_N 1.446 0.99
216_E 257_G 1.433 0.99
151_V 191_I 1.431 0.99
12_I 37_G 1.416 0.99
26_E 49_L 1.414 0.99
149_G 173_S 1.412 0.99
48_H 53_V 1.411 0.99
158_T 175_C 1.404 0.99
9_T 68_A 1.4 0.99
83_L 114_E 1.397 0.99
86_I 117_V 1.392 0.99
110_V 113_D 1.388 0.99
95_T 108_V 1.37 0.99
149_G 201_T 1.368 0.99
14_Q 69_S 1.366 0.99
232_G 271_V 1.351 0.99
83_L 87_D 1.336 0.99
71_I 81_S 1.335 0.99
106_L 110_V 1.313 0.99
25_S 51_L 1.287 0.98
57_V 85_A 1.282 0.98
188_F 208_G 1.275 0.98
94_I 127_V 1.275 0.98
42_G 55_N 1.268 0.98
206_M 232_G 1.261 0.98
58_R 62_A 1.26 0.98
22_T 48_H 1.257 0.98
223_K 268_A 1.256 0.98
184_P 187_N 1.253 0.98
111_K 115_A 1.242 0.98
13_C 25_S 1.234 0.98
110_V 114_E 1.23 0.98
272_K 283_A 1.23 0.98
3_I 176_V 1.221 0.98
43_K 46_T 1.218 0.97
82_I 108_V 1.215 0.97
80_D 84_E 1.212 0.97
130_P 173_S 1.206 0.97
80_D 83_L 1.205 0.97
78_C 95_T 1.204 0.97
120_I 127_V 1.201 0.97
150_I 172_Q 1.194 0.97
146_G 171_G 1.191 0.97
38_G 51_L 1.186 0.97
205_V 284_L 1.184 0.97
86_I 111_K 1.162 0.96
112_L 116_G 1.16 0.96
65_G 88_A 1.158 0.96
168_Y 285_K 1.146 0.96
109_K 113_D 1.142 0.96
221_Y 225_H 1.139 0.96
272_K 287_V 1.136 0.96
150_I 165_T 1.126 0.95
217_E 221_Y 1.123 0.95
217_E 220_A 1.12 0.95
124_C 177_G 1.115 0.95
75_A 97_T 1.108 0.95
120_I 186_S 1.108 0.95
43_K 53_V 1.107 0.95
69_S 90_I 1.105 0.95
16_F 48_H 1.104 0.95
132_E 145_P 1.094 0.94
28_A 70_V 1.087 0.94
22_T 49_L 1.08 0.94
18_G 43_K 1.08 0.94
196_E 226_V 1.074 0.94
54_F 61_V 1.065 0.93
272_K 286_T 1.064 0.93
25_S 29_I 1.064 0.93
118_R 194_M 1.058 0.93
166_T 172_Q 1.058 0.93
264_A 267_E 1.055 0.93
24_H 96_I 1.052 0.93
260_D 264_A 1.04 0.92
87_D 111_K 1.038 0.92
16_F 51_L 1.036 0.92
129_T 174_T 1.025 0.91
12_I 66_A 1.024 0.91
181_D 188_F 1.009 0.91
174_T 201_T 1.009 0.91
47_T 51_L 1.004 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2csuA20.93771000.199Contact Map0.758
3pffA10.96541000.216Contact Map0.639
2yv1A10.99311000.264Contact Map0.75
2nu8A20.99651000.265Contact Map0.767
2fp4A111000.265Contact Map0.68
3mwdB10.96541000.269Contact Map0.543
1oi7A10.99311000.286Contact Map0.779
2yv2A111000.295Contact Map0.739
3dmyA20.78891000.373Contact Map0.584
3ff4A10.411899.90.704Contact Map0.514
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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