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OPENSEQ.org
SRP54 - Signal recognition particle protein
UniProt: P0AGD7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10300
Length: 453 (439)
Sequences: 1545
Seq/Len: 3.52
SRP54
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
152_A 159_F 4.387 1.00
315_Q 336_E 3.675 1.00
206_K 239_A 3.632 1.00
105_M 117_V 3.449 1.00
203_D 207_Q 3.388 1.00
234_K 238_E 3.33 1.00
332_N 389_A 3.299 1.00
189_V 212_I 3.16 1.00
146_K 149_E 3.148 1.00
196_H 228_D 3.118 1.00
339_R 377_E 3.023 1.00
162_S 174_A 3.005 1.00
400_R 404_A 2.928 1.00
178_E 182_K 2.853 1.00
118_G 279_T 2.808 1.00
28_K 56_K 2.782 1.00
394_I 417_L 2.778 1.00
342_K 377_E 2.772 1.00
117_V 188_L 2.763 1.00
160_F 174_A 2.739 1.00
237_N 268_K 2.586 1.00
158_D 184_Y 2.552 1.00
68_L 304_I 2.507 1.00
334_F 420_F 2.477 1.00
51_F 55_V 2.474 1.00
335_L 381_N 2.392 1.00
177_K 181_L 2.367 1.00
276_G 281_A 2.319 1.00
149_E 153_E 2.306 1.00
167_K 207_Q 2.27 1.00
170_D 174_A 2.249 1.00
409_Q 412_D 2.236 1.00
315_Q 318_K 2.16 1.00
58_K 80_N 2.109 1.00
386_K 393_I 2.099 1.00
124_L 186_V 2.087 1.00
172_V 212_I 2.073 1.00
379_I 413_V 2.051 1.00
403_A 413_V 2.009 1.00
118_G 151_L 2.004 1.00
137_A 172_V 2.001 1.00
81_E 84_A 1.999 1.00
301_L 304_I 1.991 1.00
134_V 152_A 1.977 1.00
50_E 264_H 1.944 1.00
169_V 211_S 1.928 1.00
331_L 417_L 1.913 1.00
135_V 175_A 1.907 1.00
66_K 314_A 1.889 1.00
122_K 126_E 1.873 1.00
394_I 402_I 1.872 1.00
167_K 170_D 1.849 0.99
117_V 134_V 1.841 0.99
50_E 54_R 1.827 0.99
134_V 188_L 1.808 0.99
76_K 80_N 1.806 0.99
317_E 321_S 1.792 0.99
133_L 178_E 1.782 0.99
121_G 157_V 1.764 0.99
54_R 84_A 1.751 0.99
79_R 83_V 1.745 0.99
375_R 412_D 1.74 0.99
149_E 161_P 1.726 0.99
125_R 157_V 1.715 0.99
218_L 246_V 1.704 0.99
320_A 324_K 1.695 0.99
250_V 273_L 1.683 0.99
84_A 88_E 1.668 0.99
151_L 155_V 1.642 0.98
93_L 124_L 1.634 0.98
122_K 282_L 1.616 0.98
130_K 186_V 1.599 0.98
125_R 156_G 1.598 0.98
347_M 351_M 1.596 0.98
139_V 171_I 1.595 0.98
308_E 313_R 1.593 0.98
313_R 317_E 1.583 0.98
58_K 81_E 1.566 0.98
53_N 57_E 1.565 0.98
173_N 177_K 1.564 0.98
90_N 284_P 1.551 0.98
79_R 292_S 1.549 0.98
58_K 84_A 1.547 0.97
139_V 168_P 1.546 0.97
31_L 52_I 1.537 0.97
169_V 208_V 1.523 0.97
286_H 302_S 1.515 0.97
19_R 26_N 1.508 0.97
386_K 390_K 1.506 0.97
53_N 56_K 1.505 0.97
140_Y 171_I 1.5 0.97
102_V 189_V 1.487 0.97
131_K 184_Y 1.485 0.97
375_R 408_M 1.477 0.96
377_E 381_N 1.461 0.96
306_D 353_K 1.457 0.96
155_V 279_T 1.447 0.96
379_I 416_L 1.433 0.96
177_K 180_K 1.428 0.95
379_I 408_M 1.414 0.95
176_L 187_L 1.401 0.95
216_E 271_K 1.4 0.95
332_N 385_M 1.397 0.95
25_D 28_K 1.38 0.94
217_T 240_L 1.379 0.94
209_H 241_P 1.371 0.94
103_V 188_L 1.37 0.94
203_D 206_K 1.365 0.94
242_L 268_K 1.364 0.94
122_K 280_E 1.361 0.94
132_V 184_Y 1.354 0.93
420_F 424_Q 1.354 0.93
169_V 207_Q 1.351 0.93
289_R 305_E 1.339 0.93
153_E 156_G 1.331 0.93
330_D 389_A 1.329 0.93
27_V 60_V 1.323 0.92
97_A 215_V 1.314 0.92
140_Y 204_E 1.312 0.92
334_F 338_L 1.306 0.92
31_L 56_K 1.3 0.92
247_L 259_A 1.298 0.91
228_D 231_N 1.282 0.91
166_Q 170_D 1.277 0.91
196_H 232_T 1.273 0.90
209_H 217_T 1.271 0.90
218_L 244_G 1.26 0.90
135_V 187_L 1.259 0.90
120_L 246_V 1.256 0.90
126_E 309_S 1.25 0.89
408_M 411_Q 1.245 0.89
396_G 399_K 1.242 0.89
406_C 409_Q 1.242 0.89
399_K 417_L 1.242 0.89
95_L 186_V 1.24 0.89
133_L 184_Y 1.227 0.88
235_A 239_A 1.226 0.88
122_K 125_R 1.225 0.88
170_D 173_N 1.217 0.88
96_A 99_P 1.21 0.87
26_N 74_F 1.201 0.87
317_E 320_A 1.193 0.86
54_R 81_E 1.189 0.86
371_K 374_V 1.188 0.86
172_V 211_S 1.188 0.86
93_L 218_L 1.181 0.85
116_S 274_G 1.179 0.85
241_P 268_K 1.178 0.85
132_V 158_D 1.178 0.85
273_L 290_I 1.177 0.85
134_V 159_F 1.166 0.84
207_Q 210_A 1.165 0.84
16_I 30_T 1.161 0.84
196_H 235_A 1.16 0.84
176_L 212_I 1.154 0.83
396_G 410_V 1.153 0.83
208_V 212_I 1.152 0.83
68_L 301_L 1.145 0.83
14_R 18_G 1.14 0.82
312_D 315_Q 1.138 0.82
105_M 246_V 1.138 0.82
135_V 172_V 1.12 0.81
52_I 75_V 1.115 0.81
95_L 130_K 1.114 0.80
50_E 53_N 1.112 0.80
221_V 262_I 1.108 0.80
101_A 215_V 1.105 0.80
314_A 318_K 1.104 0.80
354_L 357_M 1.102 0.79
105_M 274_G 1.102 0.79
151_L 279_T 1.101 0.79
230_A 265_I 1.101 0.79
96_A 101_A 1.099 0.79
372_V 419_Q 1.098 0.79
339_R 381_N 1.093 0.79
152_A 158_D 1.088 0.78
176_L 180_K 1.088 0.78
250_V 290_I 1.088 0.78
95_L 101_A 1.088 0.78
178_E 181_L 1.079 0.77
335_L 377_E 1.078 0.77
123_F 127_K 1.078 0.77
102_V 187_L 1.075 0.77
210_A 213_N 1.074 0.77
175_A 187_L 1.073 0.77
172_V 176_L 1.072 0.77
102_V 176_L 1.068 0.76
200_A 203_D 1.065 0.76
165_G 170_D 1.059 0.76
30_T 74_F 1.047 0.74
133_L 158_D 1.046 0.74
145_I 163_D 1.046 0.74
104_L 205_I 1.044 0.74
346_G 349_S 1.041 0.74
140_Y 168_P 1.04 0.74
216_E 243_T 1.034 0.73
342_K 370_D 1.033 0.73
158_D 178_E 1.026 0.72
199_E 203_D 1.025 0.72
318_K 321_S 1.022 0.72
173_N 211_S 1.016 0.71
152_A 155_V 1.008 0.70
8_R 40_E 1.005 0.70
347_M 350_L 1.005 0.70
178_E 184_Y 1.004 0.70
9_L 12_T 1.003 0.70
11_R 14_R 1.003 0.70
379_I 403_A 1.002 0.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2xxaA20.95361000.383Contact Map0.663
2ffhA30.93821000.386Contact Map0.617
2v3cC20.9471000.395Contact Map0.564
2j37W10.99121000.421Contact Map0.548
3dm5A20.97131000.448Contact Map0.721
3kl4A10.93821000.454Contact Map0.56
4c7oA20.65561000.617Contact Map0.753
1ls1A10.65121000.637Contact Map0.642
2yhsA10.66231000.66Contact Map0.633
2og2A10.64241000.666Contact Map0.652
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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