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OPENSEQ.org
RS1 - 30S ribosomal protein S1
UniProt: P0AG67 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10900
Length: 557 (549)
Sequences: 1056
Seq/Len: 1.92
RS1
Paralog alert: 0.11 [within 20: 0.09] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
196_K 240_E 4.096 1.00
368_E 414_E 3.579 1.00
236_N 239_D 3.439 1.00
196_K 242_T 3.237 1.00
389_G 431_L 3.183 1.00
368_E 416_A 3.138 1.00
25_R 67_E 3.027 1.00
455_T 500_E 3.026 1.00
281_T 327_V 2.927 1.00
302_G 344_L 2.85 1.00
27_V 67_E 2.67 1.00
432_G 435_Q 2.632 1.00
464_K 477_Y 2.466 1.00
465_G 477_Y 2.426 1.00
274_Y 297_E 2.425 1.00
362_N 365_D 2.422 1.00
476_G 517_L 2.387 1.00
466_A 495_L 2.355 1.00
109_T 151_E 2.247 1.00
282_G 294_V 2.246 1.00
377_F 390_L 2.221 1.00
457_K 500_E 2.103 0.99
370_K 414_E 2.101 0.99
345_G 348_Q 2.088 0.99
223_M 235_V 2.066 0.99
383_L 429_I 2.05 0.99
207_A 235_V 2.003 0.99
367_V 417_A 1.993 0.99
455_T 502_E 1.968 0.99
379_I 409_Y 1.956 0.99
26_G 38_V 1.951 0.99
216_G 257_L 1.942 0.99
273_R 297_E 1.921 0.98
7_Q 11_E 1.903 0.98
283_R 327_V 1.889 0.98
190_Q 193_M 1.839 0.98
361_H 384_D 1.827 0.98
275_P 278_T 1.826 0.98
546_A 549_E 1.78 0.97
456_G 468_V 1.778 0.97
110_G 154_F 1.769 0.97
55_N 59_E 1.767 0.97
410_K 413_D 1.766 0.97
464_K 467_T 1.762 0.97
547_M 551_F 1.762 0.97
207_A 223_M 1.753 0.97
496_S 499_D 1.737 0.96
279_K 331_M 1.674 0.95
415_I 433_V 1.633 0.94
469_E 473_G 1.625 0.94
449_K 452_A 1.615 0.94
542_F 545_N 1.611 0.94
9_F 13_L 1.61 0.94
467_T 477_Y 1.602 0.94
366_R 416_A 1.595 0.94
420_L 432_G 1.588 0.93
35_V 47_A 1.583 0.93
246_L 258_G 1.576 0.93
479_R 516_S 1.573 0.93
6_A 10_E 1.545 0.92
274_Y 332_V 1.543 0.92
457_K 469_E 1.542 0.92
5_F 9_F 1.523 0.91
195_V 245_V 1.52 0.91
33_K 245_V 1.506 0.91
534_V 547_M 1.502 0.91
279_K 329_E 1.499 0.90
281_T 329_E 1.498 0.90
241_I 259_L 1.491 0.90
379_I 396_I 1.479 0.90
467_T 479_R 1.447 0.88
541_N 544_N 1.447 0.88
258_G 261_Q 1.437 0.88
110_G 122_V 1.435 0.88
194_E 242_T 1.432 0.88
470_L 515_I 1.431 0.88
423_D 426_R 1.429 0.87
464_K 479_R 1.415 0.87
333_L 345_G 1.409 0.86
119_G 130_F 1.406 0.86
366_R 418_V 1.404 0.86
18_T 72_L 1.398 0.86
6_A 9_F 1.398 0.86
4_S 7_Q 1.398 0.86
86_R 90_K 1.387 0.85
323_N 326_D 1.382 0.85
458_V 501_V 1.38 0.85
505_F 517_L 1.377 0.85
546_A 550_A 1.37 0.84
25_R 69_D 1.368 0.84
490_D 493_L 1.367 0.84
265_D 340_R 1.362 0.84
304_V 344_L 1.352 0.83
476_G 503_A 1.351 0.83
460_A 467_T 1.346 0.83
3_E 6_A 1.341 0.82
70_V 84_L 1.332 0.82
483_A 491_A 1.331 0.82
120_F 136_V 1.329 0.82
304_V 322_V 1.328 0.82
389_G 417_A 1.328 0.82
109_T 153_E 1.326 0.82
69_D 93_E 1.323 0.81
503_A 519_V 1.31 0.80
392_H 430_S 1.309 0.80
222_D 258_G 1.308 0.80
9_F 12_S 1.308 0.80
36_V 48_I 1.304 0.80
207_A 218_L 1.302 0.80
303_L 343_S 1.3 0.80
392_H 395_D 1.298 0.80
38_V 48_I 1.294 0.79
279_K 332_V 1.291 0.79
365_D 419_V 1.286 0.79
73_D 88_K 1.284 0.79
132_P 167_V 1.273 0.78
395_D 432_G 1.253 0.76
532_A 536_K 1.245 0.76
503_A 517_L 1.241 0.75
296_I 342_I 1.238 0.75
287_L 326_D 1.237 0.75
372_K 388_D 1.236 0.75
478_L 503_A 1.234 0.75
483_A 495_L 1.234 0.75
336_D 339_R 1.232 0.74
477_Y 516_S 1.23 0.74
184_Q 188_N 1.228 0.74
509_D 512_N 1.227 0.74
108_V 154_F 1.226 0.74
479_R 482_E 1.225 0.74
292_C 309_M 1.221 0.73
524_E 531_I 1.214 0.73
359_E 419_V 1.21 0.73
541_N 545_N 1.205 0.72
351_A 356_Q 1.203 0.72
484_S 520_R 1.197 0.71
304_V 328_V 1.196 0.71
458_V 499_D 1.195 0.71
539_D 544_N 1.193 0.71
7_Q 10_E 1.191 0.71
31_I 60_L 1.189 0.71
122_V 132_P 1.187 0.70
195_V 243_V 1.187 0.70
529_D 533_T 1.176 0.69
506_T 518_S 1.174 0.69
219_H 256_S 1.173 0.69
102_Y 156_V 1.172 0.69
419_V 431_L 1.171 0.69
154_F 168_V 1.17 0.69
483_A 519_V 1.163 0.68
549_E 552_K 1.162 0.68
32_D 37_L 1.159 0.68
112_I 154_F 1.157 0.68
535_N 546_A 1.151 0.67
542_F 548_A 1.147 0.67
380_F 388_D 1.145 0.66
112_I 120_F 1.139 0.66
492_T 497_V 1.138 0.66
465_G 479_R 1.136 0.66
293_F 303_L 1.131 0.65
542_F 546_A 1.13 0.65
209_V 218_L 1.126 0.65
457_K 483_A 1.123 0.64
550_A 553_A 1.121 0.64
527_E 531_I 1.118 0.64
539_D 542_F 1.117 0.64
10_E 13_L 1.116 0.64
381_I 474_V 1.111 0.63
120_F 147_L 1.11 0.63
547_M 553_A 1.11 0.63
538_E 541_N 1.109 0.63
191_E 247_K 1.108 0.63
458_V 488_V 1.107 0.63
450_K 506_T 1.106 0.63
358_A 424_A 1.104 0.62
488_V 508_V 1.098 0.62
361_H 419_V 1.098 0.62
197_G 209_V 1.097 0.62
111_V 151_E 1.096 0.61
476_G 505_F 1.096 0.61
546_A 553_A 1.096 0.61
305_H 343_S 1.096 0.61
454_V 503_A 1.095 0.61
536_K 547_M 1.095 0.61
276_E 300_V 1.093 0.61
198_I 240_E 1.092 0.61
68_V 199_V 1.092 0.61
378_G 390_L 1.091 0.61
28_V 62_I 1.09 0.61
13_L 38_V 1.088 0.61
547_M 550_A 1.081 0.60
390_L 430_S 1.075 0.59
129_A 168_V 1.071 0.59
528_K 542_F 1.069 0.59
5_F 8_L 1.068 0.59
531_I 535_N 1.068 0.59
33_K 50_A 1.067 0.58
208_F 215_D 1.067 0.58
230_H 233_E 1.066 0.58
542_F 550_A 1.064 0.58
549_E 553_A 1.059 0.58
420_L 435_Q 1.055 0.57
3_E 8_L 1.051 0.57
118_G 130_F 1.048 0.56
459_T 467_T 1.048 0.56
379_I 391_V 1.047 0.56
292_C 322_V 1.046 0.56
4_S 9_F 1.045 0.56
529_D 534_V 1.043 0.56
534_V 546_A 1.042 0.56
525_A 532_A 1.039 0.55
465_G 518_S 1.039 0.55
545_N 550_A 1.035 0.55
504_K 525_A 1.034 0.55
535_N 538_E 1.032 0.55
11_E 14_K 1.032 0.55
404_E 407_R 1.031 0.54
309_M 318_P 1.029 0.54
533_T 539_D 1.028 0.54
272_K 281_T 1.027 0.54
120_F 131_L 1.021 0.53
536_K 541_N 1.021 0.53
374_I 409_Y 1.019 0.53
202_L 207_A 1.019 0.53
533_T 537_Q 1.018 0.53
282_G 423_D 1.017 0.53
531_I 552_K 1.017 0.53
322_V 346_L 1.016 0.53
290_Y 303_L 1.016 0.53
360_T 384_D 1.016 0.53
119_G 291_G 1.015 0.53
100_K 104_D 1.014 0.53
538_E 542_F 1.014 0.53
369_G 391_V 1.014 0.53
28_V 64_V 1.013 0.53
402_G 405_A 1.013 0.53
63_Q 66_D 1.012 0.52
215_D 219_H 1.008 0.52
377_F 380_F 1.008 0.52
223_M 231_P 1.006 0.52
225_W 261_Q 1.006 0.52
443_N 447_L 1.004 0.52
72_L 84_L 1.003 0.51
534_V 545_N 1.002 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3go5A10.49551000.693Contact Map0.57
1q8kA10.454299.90.81Contact Map0.353
2k4kA10.229899.90.843Contact Map0.668
1hh2P10.53599.80.849Contact Map0.343
3aevA10.436399.80.85Contact Map0.681
2khiA10.206599.80.859Contact Map0.537
2khjA10.195799.70.862Contact Map0.484
2a19A10.29899.70.869Contact Map0.726
3cw2C40.44799.60.875Contact Map0.603
2je6I10.418399.60.878Contact Map0.521
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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