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OPENSEQ.org
UBIX - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
UniProt: P0AG03 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11044
Length: 189 (185)
Sequences: 972
Seq/Len: 5.25
UBIX
Paralog alert: 0.25 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
133_R 140_E 3.255 1.00
129_L 139_A 3.166 1.00
92_L 135_M 3.079 1.00
133_R 137_Q 3.024 1.00
19_R 164_N 2.911 1.00
138_A 143_A 2.795 1.00
35_V 72_I 2.748 1.00
9_S 104_L 2.739 1.00
7_G 104_L 2.681 1.00
172_D 185_R 2.586 1.00
3_R 31_E 2.502 1.00
129_L 140_E 2.339 1.00
93_S 99_Y 2.263 1.00
85_L 121_C 2.181 1.00
8_I 17_G 2.107 1.00
129_L 136_T 2.077 1.00
112_L 143_A 2.037 1.00
39_A 68_I 1.985 1.00
160_D 164_N 1.946 1.00
83_V 170_V 1.905 1.00
84_I 95_I 1.88 1.00
20_L 83_V 1.853 1.00
132_L 136_T 1.798 1.00
19_R 22_Q 1.749 1.00
63_H 71_S 1.748 1.00
89_I 122_V 1.739 1.00
127_L 149_V 1.72 1.00
89_I 134_L 1.666 0.99
37_S 104_L 1.631 0.99
168_N 183_F 1.627 0.99
115_R 139_A 1.616 0.99
133_R 136_T 1.595 0.99
109_D 131_H 1.583 0.99
87_C 92_L 1.486 0.99
83_V 174_F 1.436 0.98
112_L 141_I 1.436 0.98
85_L 170_V 1.421 0.98
5_I 111_V 1.419 0.98
92_L 138_A 1.407 0.98
136_T 140_E 1.385 0.97
146_M 166_T 1.384 0.97
89_I 93_S 1.363 0.97
115_R 144_V 1.348 0.97
121_C 170_V 1.335 0.97
94_G 99_Y 1.328 0.96
98_S 134_L 1.324 0.96
82_M 111_V 1.314 0.96
159_L 162_V 1.304 0.96
33_H 63_H 1.288 0.96
94_G 101_D 1.285 0.95
93_S 134_L 1.277 0.95
112_L 128_H 1.273 0.95
82_M 107_A 1.27 0.95
129_L 141_I 1.267 0.95
78_Q 177_T 1.265 0.95
20_L 170_V 1.256 0.95
81_G 174_F 1.254 0.95
16_Y 148_P 1.245 0.94
6_V 85_L 1.245 0.94
82_M 108_A 1.241 0.94
17_G 85_L 1.234 0.94
27_V 176_I 1.232 0.94
152_F 163_I 1.231 0.94
79_T 111_V 1.226 0.94
130_G 134_L 1.223 0.94
90_K 105_T 1.216 0.93
49_D 155_R 1.214 0.93
144_V 173_Q 1.189 0.92
100_T 109_D 1.18 0.92
93_S 97_H 1.173 0.92
157_Q 161_D 1.153 0.91
20_L 167_V 1.149 0.91
169_R 183_F 1.137 0.90
128_H 134_L 1.133 0.90
65_A 102_G 1.124 0.89
69_A 73_S 1.122 0.89
38_Q 66_R 1.12 0.89
90_K 99_Y 1.111 0.89
14_A 44_L 1.109 0.88
98_S 130_G 1.101 0.88
73_S 103_L 1.088 0.87
5_I 79_T 1.075 0.86
138_A 145_I 1.07 0.86
16_Y 150_P 1.063 0.85
38_Q 65_A 1.06 0.85
30_I 80_L 1.059 0.85
90_K 94_G 1.049 0.84
31_E 77_F 1.042 0.84
119_V 174_F 1.039 0.84
87_C 135_M 1.037 0.83
44_L 48_T 1.022 0.82
23_V 26_D 1.019 0.82
110_V 113_K 1.014 0.82
5_I 72_I 1.014 0.82
33_H 77_F 1.004 0.81
19_R 160_D 1.003 0.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zquA10.98411000.335Contact Map0.572
2ejbA10.97881000.34Contact Map0.594
1sbzA40.98411000.348Contact Map0.787
3lqkA10.97351000.486Contact Map0.365
3mcuA60.9631000.517Contact Map0.471
1g63A120.84661000.527Contact Map0.562
1qzuA40.89421000.532Contact Map0.354
1p3y110.89951000.55Contact Map0.385
3qjgA120.82541000.565Contact Map0.545
1mvlA10.85711000.584Contact Map0.398
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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