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OPENSEQ.org
YEBA - Uncharacterized metalloprotease YebA
UniProt: P0AFS9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10013
Length: 440 (384)
Sequences: 730
Seq/Len: 1.90
YEBA
Paralog alert: 0.11 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
327_V 363_L 4.829 1.00
296_S 320_A 3.691 1.00
385_N 389_S 3.168 1.00
329_S 350_I 3.073 1.00
317_V 408_L 2.784 1.00
406_N 409_T 2.719 1.00
363_L 381_A 2.546 1.00
423_R 427_L 2.445 1.00
344_A 361_M 2.384 1.00
317_V 407_P 2.377 1.00
300_N 313_P 2.373 1.00
330_V 396_Y 2.294 1.00
217_M 253_V 2.268 1.00
157_S 160_E 2.208 1.00
338_A 368_V 2.198 1.00
308_T 388_R 2.19 0.99
346_Y 386_T 2.184 0.99
347_Y 359_R 2.102 0.99
340_R 346_Y 2.1 0.99
335_V 368_V 2.07 0.99
190_G 232_F 2.061 0.99
265_I 430_A 2.06 0.99
367_L 382_L 2.005 0.99
308_T 312_A 2.004 0.99
274_D 278_T 1.984 0.99
368_V 372_Q 1.979 0.99
206_T 209_E 1.896 0.98
256_R 261_D 1.884 0.98
323_Q 383_S 1.879 0.98
304_T 309_G 1.838 0.98
200_A 210_V 1.82 0.97
343_A 388_R 1.739 0.96
396_Y 412_L 1.729 0.96
16_P 19_H 1.722 0.96
167_T 171_G 1.695 0.96
323_Q 364_R 1.67 0.95
265_I 275_R 1.603 0.94
110_L 120_I 1.596 0.93
237_S 248_S 1.572 0.93
344_A 359_R 1.558 0.92
300_N 311_V 1.55 0.92
348_V 363_L 1.513 0.91
194_G 199_S 1.491 0.90
295_I 320_A 1.485 0.90
307_V 388_R 1.485 0.90
337_V 341_S 1.479 0.89
265_I 274_D 1.478 0.89
321_M 383_S 1.474 0.89
368_V 382_L 1.468 0.89
338_A 366_I 1.446 0.88
166_R 172_F 1.432 0.87
319_F 408_L 1.431 0.87
304_T 311_V 1.422 0.87
323_Q 385_N 1.405 0.86
330_V 394_L 1.398 0.86
139_L 397_E 1.397 0.86
225_K 283_G 1.395 0.85
265_I 434_V 1.389 0.85
307_V 389_S 1.379 0.85
347_Y 361_M 1.369 0.84
223_F 376_R 1.365 0.84
341_S 347_Y 1.353 0.83
312_A 388_R 1.336 0.82
332_D 375_K 1.333 0.82
344_A 349_A 1.323 0.81
329_S 396_Y 1.317 0.81
336_V 351_R 1.308 0.80
120_I 124_A 1.284 0.78
279_G 426_F 1.274 0.78
222_D 376_R 1.263 0.77
26_L 30_T 1.262 0.77
349_A 359_R 1.259 0.76
343_A 361_M 1.247 0.75
110_L 141_W 1.244 0.75
336_V 357_T 1.243 0.75
220_Q 282_K 1.232 0.74
263_Y 275_R 1.224 0.73
286_R 412_L 1.223 0.73
185_N 251_L 1.21 0.72
254_R 263_Y 1.208 0.72
309_G 327_V 1.204 0.72
315_R 404_A 1.201 0.71
200_A 205_L 1.196 0.71
298_N 406_N 1.193 0.71
333_G 350_I 1.189 0.70
195_S 198_A 1.185 0.70
141_W 149_L 1.179 0.69
344_A 347_Y 1.179 0.69
168_A 171_G 1.174 0.69
144_T 148_E 1.171 0.69
399_W 404_A 1.165 0.68
184_V 240_M 1.158 0.67
106_L 195_S 1.15 0.67
206_T 247_Q 1.142 0.66
341_S 361_M 1.141 0.66
365_K 382_L 1.139 0.66
308_T 389_S 1.139 0.66
369_K 372_Q 1.139 0.66
335_V 348_V 1.137 0.65
257_S 291_K 1.129 0.65
284_F 398_V 1.127 0.64
55_E 64_P 1.127 0.64
400_I 405_V 1.126 0.64
306_P 390_T 1.126 0.64
284_F 331_G 1.124 0.64
335_V 372_Q 1.116 0.63
252_G 284_F 1.114 0.63
264_A 284_F 1.111 0.63
237_S 249_Q 1.108 0.62
235_L 363_L 1.108 0.62
44_D 52_I 1.106 0.62
329_S 374_V 1.103 0.62
205_L 209_E 1.102 0.62
139_L 395_H 1.101 0.62
274_D 430_A 1.096 0.61
338_A 372_Q 1.095 0.61
264_A 280_L 1.09 0.61
397_E 400_I 1.089 0.60
237_S 251_L 1.088 0.60
231_E 256_R 1.085 0.60
334_E 373_K 1.083 0.60
338_A 370_P 1.083 0.60
317_V 335_V 1.08 0.59
340_R 344_A 1.076 0.59
262_Y 273_Y 1.075 0.59
15_L 19_H 1.072 0.59
222_D 331_G 1.067 0.58
104_D 108_S 1.066 0.58
210_V 300_N 1.062 0.58
211_S 214_I 1.057 0.57
44_D 64_P 1.055 0.57
196_F 209_E 1.052 0.56
274_D 356_Y 1.052 0.56
359_R 404_A 1.05 0.56
349_A 365_K 1.05 0.56
240_M 245_R 1.049 0.56
293_F 320_A 1.049 0.56
287_F 319_F 1.045 0.56
364_R 382_L 1.044 0.56
266_R 269_D 1.039 0.55
223_F 232_F 1.039 0.55
15_L 20_R 1.037 0.55
249_Q 266_R 1.035 0.55
300_N 388_R 1.034 0.55
396_Y 432_E 1.029 0.54
338_A 348_V 1.028 0.54
188_L 236_M 1.024 0.53
290_A 328_L 1.019 0.53
214_I 218_Q 1.016 0.53
256_R 259_G 1.015 0.52
430_A 434_V 1.014 0.52
15_L 23_L 1.014 0.52
32_A 37_R 1.007 0.52
340_R 347_Y 1.005 0.51
35_V 64_P 1.001 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3sluA20.80451000.357Contact Map0.621
2gu1A10.81000.376Contact Map0.6
2hsiA20.51141000.71Contact Map0.71
3tufB10.41141000.724Contact Map0.524
3nyyA10.48181000.73Contact Map0.486
4bh5A40.30231000.735Contact Map0.67
1qwyA10.58861000.746Contact Map0.614
3it5A40.34321000.754Contact Map0.481
3csqA40.65681000.759Contact Map0.296
1e0gA10.109196.70.95Contact Map0.467
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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