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OPENSEQ.org
YADH - Inner membrane transport permease YadH
UniProt: P0AFN6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12321
Length: 256 (248)
Sequences: 5035
Seq/Len: 20.30
YADH
Paralog alert: 0.74 [within 20: 0.25] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
14_A 18_H 4.113 1.00
145_T 213_G 4.034 1.00
13_W 115_A 3.038 1.00
231_G 235_V 3.018 1.00
196_P 200_G 2.817 1.00
149_T 210_M 2.548 1.00
122_I 143_A 2.528 1.00
199_Q 203_H 2.51 1.00
227_V 231_G 2.498 1.00
159_L 243_I 2.47 1.00
57_S 60_Q 2.307 1.00
212_S 229_T 2.192 1.00
200_G 204_L 2.186 1.00
12_I 108_G 2.181 1.00
10_K 14_A 2.18 1.00
65_G 215_R 2.088 1.00
63_V 128_S 2.069 1.00
13_W 111_G 2.067 1.00
8_A 104_V 2.028 1.00
197_F 200_G 2.006 1.00
202_S 208_V 1.969 1.00
197_F 201_L 1.962 1.00
151_V 237_I 1.957 1.00
101_P 104_V 1.938 1.00
9_L 107_A 1.915 1.00
9_L 13_W 1.856 1.00
18_H 21_M 1.845 1.00
16_E 109_Y 1.838 1.00
152_L 237_I 1.832 1.00
152_L 236_F 1.821 1.00
126_A 130_F 1.792 1.00
242_L 246_S 1.766 1.00
140_V 144_L 1.725 1.00
203_H 209_Y 1.703 1.00
155_L 237_I 1.667 1.00
159_L 247_L 1.66 1.00
209_Y 232_V 1.634 1.00
234_V 238_V 1.592 1.00
209_Y 229_T 1.554 1.00
114_V 151_V 1.549 1.00
58_Y 61_F 1.544 1.00
9_L 111_G 1.543 1.00
141_F 144_L 1.542 1.00
187_V 211_I 1.518 1.00
145_T 217_G 1.51 1.00
191_L 202_S 1.494 1.00
152_L 240_F 1.492 1.00
181_L 205_N 1.483 1.00
159_L 240_F 1.483 1.00
141_F 217_G 1.465 1.00
230_F 234_V 1.458 1.00
162_V 247_L 1.436 1.00
232_V 235_V 1.43 1.00
9_L 108_G 1.415 1.00
13_W 108_G 1.408 1.00
228_T 231_G 1.405 0.99
239_A 243_I 1.403 0.99
155_L 240_F 1.394 0.99
191_L 203_H 1.392 0.99
237_I 241_Y 1.389 0.99
239_A 242_L 1.362 0.99
58_Y 62_I 1.36 0.99
246_S 250_R 1.358 0.99
121_G 146_L 1.351 0.99
200_G 203_H 1.346 0.99
152_L 233_L 1.33 0.99
118_L 147_V 1.328 0.99
203_H 208_V 1.323 0.99
205_N 208_V 1.308 0.99
103_H 107_A 1.307 0.99
146_L 210_M 1.292 0.99
86_A 109_Y 1.291 0.99
103_H 245_W 1.248 0.99
122_I 126_A 1.242 0.98
144_L 148_L 1.237 0.98
68_M 207_I 1.223 0.98
213_G 226_L 1.199 0.98
191_L 199_Q 1.195 0.98
228_T 232_V 1.17 0.97
196_P 199_Q 1.168 0.97
139_W 143_A 1.165 0.97
10_K 13_W 1.161 0.97
86_A 91_N 1.154 0.97
246_S 249_Q 1.148 0.97
105_I 248_I 1.144 0.97
177_V 180_P 1.143 0.97
186_G 191_L 1.142 0.97
231_G 234_V 1.137 0.97
34_T 38_Y 1.132 0.97
48_S 193_L 1.132 0.97
17_I 21_M 1.119 0.96
166_T 169_D 1.117 0.96
235_V 239_A 1.117 0.96
9_L 104_V 1.113 0.96
155_L 241_Y 1.111 0.96
108_G 112_G 1.094 0.96
160_N 164_A 1.087 0.96
194_L 202_S 1.079 0.95
38_Y 69_M 1.076 0.95
195_P 199_Q 1.067 0.95
40_I 44_N 1.062 0.95
61_F 215_R 1.052 0.95
18_H 22_R 1.039 0.94
212_S 216_Y 1.035 0.94
164_A 169_D 1.032 0.94
21_M 24_W 1.03 0.94
171_S 175_T 1.028 0.94
150_A 154_S 1.022 0.93
235_V 238_V 1.021 0.93
79_V 157_G 1.02 0.93
145_T 230_F 1.019 0.93
118_L 122_I 1.019 0.93
224_V 227_V 1.008 0.93
186_G 208_V 1.007 0.93
91_N 95_L 1.006 0.93
6_W 9_L 1.005 0.93
36_T 127_I 1.001 0.92
142_V 218_F 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
2ks1B10.15624.80.952Contact Map0.343
2a65A10.363330.956Contact Map0.497
4bwzA10.52342.40.959Contact Map0.198
2rddB10.1252.30.959Contact Map0.509
2jwaA20.156220.96Contact Map0.489
1pi7A10.140620.96Contact Map0.902
2kluA10.136720.96Contact Map0.285
3qbgA30.25781.90.961Contact Map0.357
2l2tA20.14841.80.962Contact Map0.211
4gn0A40.19921.60.962Contact Map0.353
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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