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OPENSEQ.org

PHNA - Protein PhnA
UniProt: P0AFJ1 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10711
Length: 111 (111)
Sequences: 529
Seq/Len: 4.77

PHNA
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
57_S 81_N 2.69 1.00
66_V 71_S 2.354 1.00
60_I 73_L 2.085 1.00
72_M 98_F 2.022 1.00
45_K 51_L 2.013 1.00
92_D 102_K 1.871 1.00
17_D 22_I 1.829 1.00
11_S 25_E 1.794 1.00
73_L 98_F 1.766 1.00
90_N 105_S 1.745 1.00
3_L 14_T 1.694 0.99
91_I 108_V 1.68 0.99
90_N 106_E 1.676 0.99
59_T 75_I 1.659 0.99
3_L 21_Y 1.631 0.99
5_H 48_N 1.518 0.98
21_Y 92_D 1.503 0.98
21_Y 32_D 1.498 0.98
3_L 16_E 1.48 0.98
42_L 90_N 1.43 0.98
31_N 34_E 1.427 0.98
5_H 10_N 1.41 0.97
59_T 111_N 1.4 0.97
44_V 90_N 1.394 0.97
75_I 98_F 1.377 0.97
60_I 98_F 1.375 0.97
4_P 21_Y 1.364 0.96
22_I 27_A 1.348 0.96
5_H 21_Y 1.33 0.96
42_L 51_L 1.31 0.95
15_Y 22_I 1.29 0.95
19_G 22_I 1.269 0.94
44_V 105_S 1.265 0.94
79_V 95_I 1.26 0.94
33_A 37_Q 1.243 0.93
16_E 19_G 1.24 0.93
71_S 98_F 1.229 0.93
22_I 29_E 1.214 0.92
34_E 39_S 1.144 0.89
13_Y 92_D 1.136 0.88
79_V 101_M 1.126 0.88
8_K 28_Y 1.113 0.87
66_V 73_L 1.105 0.86
3_L 13_Y 1.105 0.86
13_Y 25_E 1.086 0.85
89_H 99_G 1.084 0.85
14_T 27_A 1.07 0.84
48_N 80_K 1.05 0.82
2_S 10_N 1.033 0.81
25_E 108_V 1.028 0.80
5_H 20_M 1.027 0.80
15_Y 29_E 1.02 0.80
13_Y 16_E 1.019 0.80
20_M 31_N 1.019 0.80
33_A 40_D 1.01 0.79
45_K 70_S 1 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2aklA111000.064Contact Map0.477
2akkA10.64861000.423Contact Map0.436
1vd4A10.387496.40.879Contact Map0.382
1qypA10.306395.90.884Contact Map0.465
2gmgA10.360493.80.897Contact Map0.262
3o9xA20.97388.60.91Contact Map0.378
1twfI10.378487.30.912Contact Map0.656
1vq8Z10.504586.90.913Contact Map0.437
3ttcA10.945986.90.913Contact Map0.163
1pftA10.414486.90.913Contact Map0.173

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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