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OPENSEQ.org

NUOK - NADH-quinone oxidoreductase subunit K
UniProt: P0AFE4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12091
Length: 100 (99)
Sequences: 2536
Seq/Len: 25.62

NUOK
Paralog alert: 0.08 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
3_P 6_H 3.508 1.00
21_G 34_G 3.38 1.00
89_N 94_S 2.32 1.00
27_N 90_L 2.064 1.00
4_L 52_Y 2.029 1.00
22_L 31_M 1.981 1.00
18_G 37_I 1.914 1.00
40_N 66_I 1.733 1.00
20_T 24_I 1.716 1.00
2_I 6_H 1.707 1.00
58_G 61_M 1.689 1.00
23_V 49_A 1.404 0.99
21_G 25_R 1.345 0.99
15_F 41_A 1.329 0.99
39_I 69_A 1.311 0.99
8_L 12_A 1.303 0.99
42_S 45_A 1.3 0.99
46_F 58_G 1.3 0.99
18_G 72_E 1.256 0.99
5_Q 9_I 1.254 0.99
75_I 78_A 1.236 0.98
50_G 60_V 1.23 0.98
83_L 95_V 1.221 0.98
15_F 38_M 1.217 0.98
2_I 5_Q 1.214 0.98
69_A 74_S 1.17 0.97
5_Q 88_Q 1.145 0.97
43_A 65_A 1.137 0.97
10_L 15_F 1.12 0.96
25_R 30_F 1.117 0.96
41_A 72_E 1.115 0.96
14_L 44_L 1.092 0.96
91_N 94_S 1.076 0.95
19_L 59_Q 1.057 0.95
23_V 59_Q 1.045 0.94
22_L 34_G 1.037 0.94
35_L 49_A 1.031 0.94
32_L 45_A 1.031 0.94
18_G 41_A 1.025 0.93
21_G 70_A 1.018 0.93
43_A 66_I 1.012 0.93
7_G 48_V 1.008 0.93
82_Q 85_R 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rkoK2199.80.078Contact Map0.497
4he8K20.9599.80.13Contact Map0.623
3rkoL20.9650.899Contact Map0.609
3rkoN20.974.20.903Contact Map0.716
3rkoM213.90.905Contact Map0.661
4he8L20.963.70.906Contact Map0.636
4he8N20.931.80.92Contact Map0.658
4he8M20.961.30.926Contact Map0.662
3nt8A20.440.90.934Contact Map0.043
2kluA10.490.70.938Contact Map0.039

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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