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OPENSEQ.org
NUOI - NADH-quinone oxidoreductase subunit I
UniProt: P0AFD6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12089
Length: 180 (178)
Sequences: 265
Seq/Len: 1.49
NUOI
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
126_K 129_D 2.508 1.00
108_A 113_A 2.406 1.00
37_P 121_E 2.256 0.99
165_E 169_E 1.947 0.98
161_K 169_E 1.919 0.97
163_K 166_A 1.857 0.96
162_D 165_E 1.834 0.96
16_S 161_K 1.765 0.95
162_D 166_A 1.673 0.93
13_Q 20_I 1.666 0.92
80_A 86_R 1.645 0.92
86_R 97_S 1.569 0.89
121_E 130_L 1.552 0.88
131_V 166_A 1.549 0.88
108_A 120_F 1.544 0.88
40_L 120_F 1.542 0.88
24_A 28_R 1.491 0.86
53_D 61_V 1.479 0.85
20_I 29_E 1.451 0.83
21_G 24_A 1.446 0.83
170_A 174_D 1.427 0.82
38_V 136_D 1.404 0.81
97_S 130_L 1.363 0.78
165_E 171_K 1.351 0.77
164_G 174_D 1.351 0.77
161_K 166_A 1.348 0.77
164_G 169_E 1.33 0.75
168_N 171_K 1.323 0.75
10_F 14_V 1.305 0.73
16_S 20_I 1.298 0.73
47_R 119_D 1.269 0.70
52_R 138_L 1.264 0.70
61_V 74_C 1.251 0.69
167_E 171_K 1.247 0.68
113_A 132_Y 1.246 0.68
124_E 131_V 1.246 0.68
65_L 87_W 1.245 0.68
165_E 168_N 1.243 0.68
11_G 14_V 1.243 0.68
101_F 133_E 1.233 0.67
32_M 36_E 1.225 0.66
149_N 152_R 1.22 0.66
21_G 29_E 1.22 0.66
17_I 21_G 1.203 0.64
21_G 28_R 1.202 0.64
161_K 165_E 1.196 0.64
133_E 136_D 1.193 0.63
162_D 170_A 1.189 0.63
106_E 114_I 1.183 0.62
43_R 85_G 1.182 0.62
164_G 168_N 1.179 0.62
126_K 136_D 1.177 0.62
19_M 142_P 1.167 0.61
161_K 168_N 1.164 0.61
24_A 165_E 1.153 0.60
48_I 92_F 1.15 0.59
124_E 130_L 1.135 0.58
97_S 131_V 1.131 0.57
77_L 91_F 1.129 0.57
54_P 172_P 1.124 0.57
77_L 95_N 1.121 0.56
67_A 91_F 1.12 0.56
45_R 104_L 1.115 0.56
18_W 165_E 1.108 0.55
79_K 87_W 1.106 0.55
163_K 168_N 1.103 0.54
20_I 168_N 1.095 0.54
131_V 163_K 1.094 0.54
58_E 134_K 1.091 0.53
15_R 19_M 1.089 0.53
130_L 138_L 1.079 0.52
23_H 55_D 1.077 0.52
65_L 134_K 1.075 0.52
68_V 87_W 1.061 0.50
52_R 141_G 1.058 0.50
22_L 26_A 1.054 0.49
106_E 116_L 1.054 0.49
29_E 165_E 1.044 0.48
54_P 81_E 1.041 0.48
168_N 174_D 1.041 0.48
96_F 119_D 1.035 0.47
162_D 174_D 1.033 0.47
50_L 134_K 1.031 0.47
171_K 174_D 1.028 0.47
3_L 21_G 1.026 0.47
31_R 44_Y 1.023 0.46
31_R 37_P 1.021 0.46
135_E 169_E 1.02 0.46
86_R 118_P 1.019 0.46
61_V 98_R 1.017 0.46
13_Q 17_I 1.017 0.46
50_L 113_A 1.01 0.45
58_E 65_L 1.01 0.45
23_H 144_K 1.006 0.44
80_A 83_K 1.002 0.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3i9v920.94441000.6Contact Map0.299
1xerA10.544499.40.805Contact Map0.289
2gmhA20.677899.30.809Contact Map0.216
1gteA40.672299.30.815Contact Map0.267
2c42A20.944499.20.819Contact Map0.199
3gyxB60.672299.20.819Contact Map0.195
1jb0C10.444499.20.82Contact Map0.142
3i9v320.911199.20.821Contact Map0.166
1hfeL20.755699.20.823Contact Map0.185
3zfsB10.611199.20.824Contact Map0.002
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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