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OPENSEQ.org
NUOE - NADH-quinone oxidoreductase subunit E
UniProt: P0AFD1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12086
Length: 166 (155)
Sequences: 1688
Seq/Len: 10.89
NUOE
Paralog alert: 0.19 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
87_H 146_D 4.358 1.00
110_E 116_K 3.131 1.00
112_K 159_P 3.131 1.00
120_T 127_T 2.973 1.00
37_I 79_I 2.809 1.00
86_R 125_R 2.735 1.00
110_E 128_L 2.604 1.00
108_A 159_P 2.463 1.00
59_A 69_V 2.307 1.00
23_E 61_V 2.134 1.00
112_K 163_E 2.034 1.00
106_Q 117_P 1.993 1.00
36_S 64_I 1.942 1.00
113_L 121_T 1.877 1.00
43_V 58_I 1.869 1.00
73_A 81_R 1.784 1.00
107_A 111_K 1.768 1.00
115_I 121_T 1.685 1.00
80_F 84_V 1.68 1.00
105_I 158_I 1.66 1.00
55_I 73_A 1.6 1.00
88_V 127_T 1.52 1.00
108_A 112_K 1.52 1.00
89_I 145_I 1.471 1.00
104_G 107_A 1.468 1.00
125_R 166_K 1.458 1.00
107_A 110_E 1.448 1.00
85_G 127_T 1.435 1.00
91_Y 106_Q 1.413 1.00
143_M 153_L 1.399 0.99
87_H 125_R 1.375 0.99
110_E 117_P 1.347 0.99
85_G 120_T 1.342 0.99
50_V 73_A 1.322 0.99
57_A 60_D 1.315 0.99
115_I 119_Q 1.314 0.99
36_S 69_V 1.312 0.99
58_I 69_V 1.299 0.99
115_I 128_L 1.292 0.99
100_N 140_G 1.287 0.99
134_L 144_M 1.266 0.99
153_L 161_L 1.26 0.99
116_K 119_Q 1.257 0.99
134_L 142_N 1.257 0.99
154_T 157_A 1.254 0.99
43_V 54_A 1.242 0.98
89_I 161_L 1.232 0.98
55_I 69_V 1.231 0.98
33_R 68_D 1.187 0.98
67_S 71_G 1.18 0.98
109_L 158_I 1.175 0.98
52_D 56_H 1.17 0.97
108_A 158_I 1.168 0.97
23_E 57_A 1.164 0.97
88_V 129_L 1.155 0.97
115_I 120_T 1.152 0.97
36_S 72_V 1.147 0.97
143_M 161_L 1.14 0.97
22_I 26_M 1.135 0.97
136_N 139_K 1.128 0.97
157_A 160_E 1.121 0.97
20_E 23_E 1.118 0.96
65_P 68_D 1.118 0.96
32_P 63_G 1.088 0.96
57_A 61_V 1.085 0.96
24_H 27_H 1.077 0.95
25_E 42_I 1.077 0.95
150_H 161_L 1.073 0.95
47_R 51_P 1.073 0.95
108_A 155_P 1.073 0.95
19_R 23_E 1.071 0.95
41_K 79_I 1.065 0.95
56_H 66_A 1.064 0.95
51_P 54_A 1.063 0.95
139_K 151_A 1.062 0.95
108_A 111_K 1.054 0.95
160_E 164_R 1.048 0.94
92_C 97_C 1.031 0.94
101_G 104_G 1.028 0.94
98_H 132_C 1.002 0.92
43_V 50_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3i9v220.93371000.166Contact Map0.718
2auvA10.51299.90.591Contact Map0.448
1m2dA20.481999.70.67Contact Map0.652
3m6zA20.867533.20.941Contact Map0.447
2w7nA20.590432.50.941Contact Map0.527
4ihuA20.716930.40.942Contact Map0.338
4jr6A20.716929.60.943Contact Map0.333
3cuqA10.843428.80.943Contact Map0.101
4gfjA10.849428.60.943Contact Map0.446
2k9lA10.451828.20.943Contact Map0.498
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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