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OPENSEQ.org

NUDB - Dihydroneopterin triphosphate pyrophosphatase
UniProt: P0AFC0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11138
Length: 150 (145)
Sequences: 217
Seq/Len: 1.50

NUDB
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
79_V 102_W 3.182 1.00
122_K 132_L 2.205 0.99
136_W 139_R 2.084 0.99
28_Q 34_D 1.97 0.98
77_R 102_W 1.684 0.93
81_F 84_F 1.643 0.92
32_D 35_F 1.583 0.90
128_A 131_A 1.566 0.89
18_A 22_K 1.542 0.88
48_T 51_Q 1.525 0.87
43_V 49_A 1.521 0.87
85_S 115_F 1.489 0.86
43_V 52_A 1.467 0.84
16_I 105_L 1.465 0.84
83_I 89_H 1.425 0.82
82_E 88_R 1.407 0.81
49_A 101_S 1.383 0.79
130_A 137_S 1.382 0.79
31_D 119_L 1.38 0.79
90_R 137_S 1.353 0.77
47_E 146_V 1.347 0.77
63_I 70_L 1.346 0.77
46_G 51_Q 1.339 0.76
23_R 110_E 1.335 0.76
80_E 102_W 1.332 0.76
75_C 104_C 1.304 0.73
136_W 140_Q 1.3 0.73
68_E 111_R 1.293 0.73
44_E 116_T 1.254 0.69
43_V 46_G 1.247 0.69
50_P 54_M 1.242 0.68
28_Q 32_D 1.231 0.67
81_F 137_S 1.231 0.67
66_V 71_T 1.23 0.67
28_Q 119_L 1.228 0.67
96_T 101_S 1.22 0.66
33_P 119_L 1.205 0.65
32_D 86_H 1.202 0.64
107_L 111_R 1.196 0.64
82_E 97_R 1.19 0.63
20_D 23_R 1.171 0.62
10_V 43_V 1.169 0.61
18_A 23_R 1.164 0.61
77_R 144_Q 1.156 0.60
64_D 70_L 1.149 0.59
6_Y 23_R 1.111 0.55
104_C 139_R 1.11 0.55
62_T 69_Q 1.102 0.55
8_R 44_E 1.099 0.54
6_Y 47_E 1.096 0.54
18_A 116_T 1.096 0.54
8_R 104_C 1.091 0.53
115_F 148_N 1.091 0.53
83_I 87_L 1.072 0.51
28_Q 82_E 1.07 0.51
46_G 114_V 1.069 0.51
51_Q 54_M 1.068 0.51
80_E 97_R 1.065 0.51
13_L 38_S 1.064 0.51
99_T 112_Q 1.062 0.50
38_S 135_S 1.05 0.49
95_V 130_A 1.049 0.49
50_P 79_V 1.048 0.49
17_Y 104_C 1.048 0.49
92_A 95_V 1.048 0.49
65_V 126_A 1.043 0.48
72_L 121_Y 1.035 0.48
6_Y 93_P 1.031 0.47
28_Q 75_C 1.031 0.47
58_K 64_D 1.027 0.47
22_K 127_P 1.022 0.46
89_H 137_S 1.019 0.46
13_L 138_N 1.017 0.46
87_L 97_R 1.015 0.46
114_V 148_N 1.011 0.45
83_I 115_F 1.003 0.44
58_K 66_V 1.002 0.44
130_A 143_E 1 0.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2o1cA4199.90.593Contact Map0.527
3sonA20.9299.80.691Contact Map0.424
1f3yA10.999.70.712Contact Map0.429
2azwA10.926799.70.714Contact Map0.409
1ktgA20.8899.70.723Contact Map0.455
2qjoA30.926799.70.723Contact Map0.35
3dupA20.9499.70.725Contact Map0.424
3fcmA20.966799.70.726Contact Map0.562
4ijxA20.8899.70.727Contact Map0.503
2kdvA10.966799.70.728Contact Map0.452

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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