OPENSEQ.org - YJEE - ECOLI GREMLIN

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YJEE - UPF0079 ATP-binding protein YjeE

UniProt:	P0AF67	Sequence MMNRVIPLPDEQATLDLGERVAKACDGATVIYLYGDLGAGKTTFSRGFLQALGHQGNVKSPTYTLVEPYTLDNLMVYHFDLYRLADPEELEFMGIRDYFANDAICLVEWPQQGTGVLPDPDVEIHIDYQAQGREARVSAVSSAGELLLARLAG	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG11757
Length:	153 (147)
Sequences:	1871
Seq/Len:	12.73

YJEE
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
8_L	14_T	2.891	1.00
44_F	48_F	2.685	1.00
10_D	13_A	2.666	1.00
45_S	106_L	2.576	1.00
18_G	44_F	2.528	1.00
34_Y	123_E	2.275	1.00
49_L	76_V	2.25	1.00
25_C	48_F	2.25	1.00
127_D	136_R	2.146	1.00
48_F	106_L	2.101	1.00
17_L	135_A	2.069	1.00
94_G	97_D	2.065	1.00
34_Y	111_Q	2.057	1.00
19_E	50_Q	2	1.00
15_L	46_R	1.994	1.00
15_L	50_Q	1.958	1.00
34_Y	125_H	1.938	1.00
49_L	58_V	1.898	1.00
33_L	45_S	1.821	1.00
47_G	51_A	1.794	1.00
18_G	47_G	1.768	1.00
9_P	13_A	1.722	1.00
126_I	135_A	1.708	1.00
21_V	44_F	1.707	1.00
77_Y	103_A	1.69	1.00
32_Y	110_P	1.617	1.00
79_F	95_I	1.617	1.00
54_H	58_V	1.586	1.00
81_L	113_G	1.57	1.00
68_P	77_Y	1.566	1.00
59_K	67_E	1.542	1.00
34_Y	110_P	1.528	1.00
15_L	47_G	1.514	1.00
8_L	17_L	1.509	1.00
8_L	135_A	1.463	1.00
141_S	144_G	1.452	1.00
25_C	31_I	1.418	1.00
99_F	105_C	1.416	1.00
26_D	29_T	1.415	1.00
127_D	134_E	1.415	1.00
32_Y	121_D	1.402	0.99
139_A	148_L	1.395	0.99
142_S	145_E	1.391	0.99
11_E	47_G	1.384	0.99
66_V	79_F	1.35	0.99
90_L	113_G	1.309	0.99
79_F	105_C	1.307	0.99
11_E	15_L	1.297	0.99
129_Q	134_E	1.295	0.99
19_E	23_K	1.293	0.99
133_R	137_V	1.287	0.99
49_L	54_H	1.285	0.99
123_E	138_S	1.285	0.99
125_H	136_R	1.276	0.99
125_H	138_S	1.222	0.98
68_P	98_Y	1.209	0.98
44_F	126_I	1.207	0.98
20_R	23_K	1.195	0.98
16_D	19_E	1.149	0.97
16_D	20_R	1.133	0.97
81_L	110_P	1.115	0.96
48_F	104_I	1.107	0.96
7_P	134_E	1.106	0.96
22_A	51_A	1.102	0.96
8_L	13_A	1.091	0.96
31_I	124_I	1.05	0.94
142_S	146_L	1.048	0.94
75_M	103_A	1.047	0.94
95_I	99_F	1.045	0.94
31_I	106_L	1.043	0.94
14_T	18_G	1.043	0.94
18_G	22_A	1.041	0.94
29_T	143_A	1.041	0.94
87_P	115_G	1.04	0.94
22_A	52_L	1.021	0.93
91_E	96_R	1.01	0.93
144_G	147_L	1.008	0.93
66_V	77_Y	1.005	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
1htwA	3	1	100	0.282	Contact Map	0.793
3tmkA	8	0.8039	97.1	0.848	Contact Map	0.429
2p5tB	4	0.9412	97	0.849	Contact Map	0.458
3umfA	1	0.9477	97	0.849	Contact Map	0.459
2v54A	2	0.7843	97	0.851	Contact Map	0.431
2j41A	4	0.817	96.9	0.852	Contact Map	0.584
2c95A	2	0.8301	96.8	0.853	Contact Map	0.341
2yogA	2	0.8562	96.8	0.854	Contact Map	0.32
1a7jA	1	0.8431	96.8	0.854	Contact Map	0.475
3kb2A	2	0.7647	96.8	0.855	Contact Map	0.384

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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