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OPENSEQ.org
MLTD - Membrane-bound lytic murein transglycosylase D
UniProt: P0AEZ7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10246
Length: 452 (393)
Sequences: 504
Seq/Len: 1.28
MLTD
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
343_Y 358_L 4.482 1.00
402_Y 417_H 4.336 1.00
343_Y 349_D 4.287 1.00
402_Y 408_D 4.152 1.00
419_V 427_W 2.935 1.00
112_R 174_L 2.887 1.00
360_V 368_W 2.707 1.00
108_Q 111_K 2.613 1.00
217_D 220_S 2.411 0.99
260_L 288_F 2.41 0.99
154_L 172_A 2.345 0.99
408_D 417_H 2.317 0.99
365_L 384_I 2.11 0.98
137_N 145_I 2.105 0.98
112_R 175_N 2.079 0.98
192_V 218_F 2.052 0.98
81_K 239_D 2.042 0.98
112_R 178_Q 2.016 0.97
114_M 178_Q 1.955 0.97
149_G 156_Q 1.947 0.97
109_V 174_L 1.893 0.96
419_V 423_D 1.882 0.96
340_S 383_T 1.882 0.96
427_W 443_F 1.862 0.95
199_E 204_K 1.822 0.95
133_T 164_R 1.743 0.93
410_L 421_I 1.743 0.93
101_Y 260_L 1.721 0.92
403_R 439_K 1.69 0.91
345_V 380_Q 1.681 0.91
350_T 353_S 1.601 0.88
424_V 442_L 1.593 0.87
197_S 223_L 1.593 0.87
177_M 191_T 1.592 0.87
193_A 231_V 1.579 0.87
366_Q 373_G 1.565 0.86
105_I 128_F 1.559 0.86
344_T 381_S 1.553 0.86
260_L 306_M 1.552 0.86
159_N 294_G 1.539 0.85
209_N 216_T 1.53 0.84
85_L 244_S 1.515 0.84
152_Y 179_R 1.512 0.83
368_W 385_G 1.502 0.83
409_S 412_S 1.483 0.82
133_T 139_A 1.481 0.82
364_D 368_W 1.454 0.80
209_N 217_D 1.446 0.80
411_S 415_K 1.442 0.79
181_N 191_T 1.429 0.78
197_S 201_R 1.427 0.78
183_M 199_E 1.424 0.78
136_A 145_I 1.416 0.78
108_Q 171_T 1.409 0.77
366_Q 371_L 1.399 0.76
152_Y 415_K 1.394 0.76
371_L 380_Q 1.384 0.75
62_F 110_K 1.367 0.74
149_G 187_D 1.359 0.73
345_V 354_I 1.353 0.73
402_Y 413_I 1.35 0.73
197_S 224_P 1.342 0.72
100_P 260_L 1.341 0.72
159_N 299_A 1.333 0.71
162_A 291_G 1.328 0.71
341_R 365_L 1.327 0.71
187_D 232_P 1.316 0.70
193_A 227_T 1.314 0.70
162_A 299_A 1.306 0.69
351_L 382_L 1.305 0.69
193_A 232_P 1.297 0.68
343_Y 354_I 1.284 0.67
227_T 232_P 1.268 0.66
420_N 423_D 1.268 0.66
102_M 119_V 1.262 0.65
174_L 178_Q 1.262 0.65
114_M 174_L 1.257 0.65
157_T 347_S 1.256 0.65
158_R 294_G 1.254 0.64
350_T 376_L 1.246 0.64
62_F 66_E 1.245 0.64
121_L 234_M 1.238 0.63
307_V 315_L 1.236 0.63
344_T 383_T 1.232 0.62
148_T 176_M 1.216 0.61
377_K 380_Q 1.212 0.61
128_F 247_Y 1.204 0.60
366_Q 374_S 1.202 0.60
428_N 437_G 1.195 0.59
108_Q 174_L 1.193 0.59
423_D 426_R 1.185 0.58
337_P 385_G 1.183 0.58
164_R 376_L 1.181 0.58
404_V 413_I 1.177 0.57
96_L 99_E 1.17 0.57
109_V 118_L 1.169 0.56
149_G 154_L 1.168 0.56
359_G 420_N 1.161 0.56
251_L 263_V 1.148 0.54
183_M 203_M 1.148 0.54
151_N 199_E 1.143 0.54
360_V 384_I 1.14 0.54
209_N 215_S 1.139 0.54
104_W 171_T 1.138 0.53
285_L 305_V 1.129 0.53
84_Y 127_A 1.129 0.53
192_V 234_M 1.121 0.52
187_D 190_L 1.12 0.52
179_R 183_M 1.113 0.51
241_L 251_L 1.108 0.50
350_T 418_G 1.105 0.50
247_Y 319_L 1.104 0.50
149_G 204_K 1.104 0.50
147_S 176_M 1.096 0.49
348_G 354_I 1.095 0.49
410_L 424_V 1.093 0.49
150_R 380_Q 1.091 0.49
271_M 274_V 1.09 0.49
80_Q 233_K 1.089 0.49
197_S 202_V 1.088 0.48
340_S 385_G 1.084 0.48
66_E 116_M 1.083 0.48
221_L 270_E 1.081 0.48
315_L 319_L 1.079 0.48
158_R 295_S 1.078 0.47
90_Y 94_V 1.078 0.47
425_M 432_A 1.078 0.47
191_T 234_M 1.072 0.47
285_L 295_S 1.069 0.47
404_V 434_L 1.068 0.46
279_G 370_K 1.064 0.46
101_Y 190_L 1.063 0.46
227_T 231_V 1.061 0.46
240_I 281_S 1.058 0.46
61_A 169_S 1.055 0.45
248_G 379_G 1.055 0.45
69_M 189_L 1.054 0.45
281_S 284_K 1.052 0.45
353_S 409_S 1.049 0.45
175_N 178_Q 1.049 0.45
356_S 403_R 1.047 0.44
194_A 377_K 1.045 0.44
61_A 65_D 1.045 0.44
169_S 248_G 1.044 0.44
159_N 297_L 1.043 0.44
157_T 249_V 1.04 0.44
218_F 271_M 1.037 0.43
271_M 297_L 1.036 0.43
351_L 371_L 1.036 0.43
280_I 311_H 1.036 0.43
114_M 118_L 1.035 0.43
400_I 444_V 1.034 0.43
102_M 344_T 1.033 0.43
285_L 296_T 1.032 0.43
76_R 307_V 1.032 0.43
274_V 315_L 1.031 0.43
119_V 128_F 1.024 0.42
110_K 116_M 1.021 0.42
149_G 290_A 1.021 0.42
226_E 232_P 1.019 0.42
274_V 278_A 1.018 0.42
141_I 378_P 1.016 0.41
109_V 141_I 1.015 0.41
202_V 232_P 1.015 0.41
362_T 365_L 1.013 0.41
89_S 93_D 1.01 0.41
118_L 443_F 1.009 0.41
382_L 423_D 1.006 0.40
189_L 235_L 1.006 0.40
63_I 280_I 1.002 0.40
274_V 298_G 1.002 0.40
269_V 274_V 1.001 0.40
84_Y 124_V 1.001 0.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3t21A20.38051000.791Contact Map0.401
1qsaA10.55971000.801Contact Map0.524
4ebyA10.39161000.817Contact Map0.627
4b8vA10.4691000.822Contact Map0.654
3w6bA40.38271000.834Contact Map0.311
4g9sA10.373999.90.836Contact Map0.438
1gbsA10.369599.90.838Contact Map0.426
3gxrA40.369599.90.839Contact Map0.553
3bkhA10.506699.90.853Contact Map0.524
2gu1A10.263399.90.86Contact Map0.52
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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