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OPENSEQ.org

SKP - Chaperone protein skp
UniProt: P0AEU7 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10455
Length: 161 (160)
Sequences: 780
Seq/Len: 4.88

SKP
Paralog alert: 0.11 [within 20: 0.08] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
131_Q 155_D 3.259 1.00
130_S 159_Q 2.472 1.00
51_K 55_S 2.385 1.00
128_A 136_V 2.326 1.00
65_Q 69_K 2.322 1.00
79_D 82_K 2.141 1.00
126_S 159_Q 2.023 1.00
42_V 116_L 2.013 1.00
28_N 139_A 2.001 1.00
92_Q 96_Q 1.983 1.00
108_R 111_E 1.957 1.00
125_K 129_N 1.894 1.00
118_T 122_T 1.892 1.00
67_K 90_Q 1.877 1.00
49_E 108_R 1.833 1.00
37_A 161_K 1.829 1.00
81_T 85_K 1.816 1.00
47_E 51_K 1.741 1.00
66_A 70_K 1.717 1.00
83_L 86_D 1.697 0.99
64_L 87_V 1.684 0.99
54_A 58_Q 1.648 0.99
77_G 81_T 1.637 0.99
44_N 47_E 1.636 0.99
127_V 156_V 1.606 0.99
63_D 67_K 1.585 0.99
96_Q 100_A 1.578 0.99
58_Q 62_T 1.526 0.99
38_Q 119_R 1.479 0.98
108_R 112_E 1.464 0.98
75_K 83_L 1.444 0.98
112_E 115_K 1.442 0.98
62_T 66_A 1.415 0.97
154_A 158_K 1.403 0.97
60_M 93_T 1.345 0.96
53_R 104_D 1.328 0.96
33_F 105_R 1.311 0.96
31_S 35_Q 1.311 0.96
136_V 152_I 1.299 0.95
82_K 86_D 1.291 0.95
40_T 44_N 1.291 0.95
26_I 135_L 1.282 0.95
29_M 43_S 1.282 0.95
84_E 89_A 1.246 0.94
57_L 101_F 1.239 0.93
41_G 45_T 1.233 0.93
56_E 59_R 1.22 0.93
61_E 94_F 1.216 0.93
36_V 120_I 1.205 0.92
137_V 142_V 1.195 0.92
31_S 157_L 1.191 0.92
45_T 112_E 1.155 0.90
28_N 31_S 1.142 0.89
68_M 72_Q 1.122 0.88
25_A 152_I 1.11 0.87
71_L 80_R 1.106 0.87
71_L 84_E 1.075 0.85
107_R 111_E 1.074 0.85
64_L 94_F 1.068 0.84
71_L 94_F 1.062 0.84
32_L 157_L 1.058 0.84
55_S 59_R 1.051 0.83
150_K 155_D 1.043 0.82
109_S 117_V 1.036 0.82
49_E 53_R 1.035 0.82
69_K 72_Q 1.023 0.81
106_A 117_V 1.021 0.80
56_E 97_K 1.011 0.80
64_L 68_M 1.004 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1u2mA30.88821000.205Contact Map0.628
4kqtA10.99381000.217Contact Map0.542
2ld3A10.540426.10.916Contact Map0.342
4etpB10.689423.30.918Contact Map0.235
3ioxA10.751618.60.922Contact Map0.256
1fxkC10.465816.90.924Contact Map0.006
2dfsA20.788814.70.925Contact Map0.321
1dj7A10.273314.60.926Contact Map0.067
3errA20.627314.50.926Contact Map0.31
2zdiC10.509310.60.93Contact Map0.073

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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