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OPENSEQ.org
GLTS - Sodium/glutamate symport carrier protein
UniProt: P0AER8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10406
Length: 401 (397)
Sequences: 544
Seq/Len: 1.37
GLTS
Paralog alert: 0.08 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
334_D 367_S 3.275 1.00
107_M 316_F 3.216 1.00
111_I 316_F 3.204 1.00
325_T 342_H 2.538 1.00
327_R 331_K 2.523 1.00
28_S 32_K 2.462 1.00
138_H 169_L 2.211 0.99
23_L 27_V 2.106 0.98
112_G 126_G 2.046 0.98
145_S 158_T 2.046 0.98
295_K 298_E 1.899 0.96
47_L 51_V 1.893 0.96
141_G 161_A 1.886 0.96
115_M 312_V 1.877 0.96
112_G 116_A 1.803 0.95
24_V 40_A 1.783 0.94
182_Y 322_I 1.736 0.93
133_T 141_G 1.723 0.93
97_F 345_F 1.707 0.93
22_K 26_S 1.686 0.92
94_V 372_L 1.677 0.92
248_F 352_T 1.672 0.91
115_M 308_A 1.668 0.91
184_V 234_V 1.666 0.91
167_F 310_L 1.644 0.91
142_A 161_A 1.631 0.90
317_M 346_G 1.63 0.90
28_S 31_K 1.617 0.90
30_L 40_A 1.613 0.89
391_K 397_P 1.594 0.89
102_V 385_V 1.589 0.88
27_V 95_G 1.555 0.87
27_V 30_L 1.551 0.87
321_A 339_A 1.524 0.86
52_L 58_W 1.517 0.85
98_L 381_F 1.514 0.85
44_L 47_L 1.512 0.85
138_H 349_A 1.488 0.84
100_V 224_I 1.456 0.82
319_L 323_F 1.454 0.82
189_T 336_A 1.437 0.81
227_C 258_L 1.427 0.80
345_F 386_N 1.42 0.80
116_A 126_G 1.415 0.79
141_G 145_S 1.407 0.79
138_H 166_T 1.406 0.79
350_T 383_D 1.402 0.78
317_M 321_A 1.399 0.78
184_V 364_F 1.373 0.76
145_S 148_F 1.368 0.76
113_I 394_L 1.358 0.75
83_N 263_S 1.353 0.75
290_A 350_T 1.351 0.75
100_V 328_M 1.347 0.74
5_D 8_A 1.329 0.73
25_H 31_K 1.323 0.72
271_F 299_L 1.321 0.72
234_V 254_V 1.312 0.72
128_L 148_F 1.306 0.71
33_Y 174_L 1.305 0.71
114_G 119_L 1.296 0.70
67_R 290_A 1.295 0.70
23_L 185_K 1.294 0.70
132_I 284_S 1.268 0.68
340_A 360_I 1.268 0.68
311_V 315_I 1.255 0.67
37_E 252_L 1.255 0.67
110_A 114_G 1.252 0.66
125_M 257_I 1.248 0.66
249_V 384_I 1.244 0.66
258_L 282_S 1.242 0.65
135_S 325_T 1.238 0.65
80_L 256_V 1.227 0.64
107_M 111_I 1.226 0.64
167_F 314_T 1.223 0.64
333_Y 337_V 1.211 0.63
182_Y 186_H 1.21 0.62
44_L 106_V 1.206 0.62
349_A 378_G 1.204 0.62
103_G 320_Y 1.201 0.62
95_G 99_I 1.199 0.61
15_L 103_G 1.196 0.61
69_P 141_G 1.193 0.61
186_H 189_T 1.187 0.60
105_L 135_S 1.184 0.60
3_H 59_E 1.177 0.59
287_L 291_L 1.169 0.59
144_W 248_F 1.165 0.58
248_F 255_G 1.163 0.58
61_N 170_V 1.162 0.58
136_G 166_T 1.16 0.58
228_L 248_F 1.152 0.57
333_Y 344_G 1.152 0.57
76_A 228_L 1.151 0.57
345_F 349_A 1.149 0.57
291_L 377_V 1.149 0.57
26_S 32_K 1.148 0.56
43_L 282_S 1.148 0.56
249_V 380_F 1.143 0.56
145_S 156_N 1.142 0.56
17_L 21_R 1.14 0.56
98_L 382_I 1.14 0.56
64_M 67_R 1.137 0.55
334_D 337_V 1.136 0.55
138_H 165_A 1.134 0.55
80_L 380_F 1.134 0.55
14_T 285_L 1.134 0.55
184_V 189_T 1.132 0.55
293_G 309_I 1.132 0.55
37_E 248_F 1.132 0.55
97_F 386_N 1.131 0.55
67_R 71_M 1.128 0.54
30_L 311_V 1.125 0.54
48_A 308_A 1.122 0.54
83_N 259_S 1.117 0.53
90_G 123_P 1.117 0.53
279_G 343_C 1.113 0.53
19_L 25_H 1.113 0.53
381_F 386_N 1.11 0.53
104_L 111_I 1.108 0.52
390_I 393_Y 1.107 0.52
51_V 257_I 1.101 0.52
136_G 169_L 1.1 0.52
70_L 179_V 1.1 0.52
367_S 370_A 1.1 0.52
81_N 369_M 1.1 0.52
127_L 132_I 1.097 0.51
160_V 248_F 1.094 0.51
77_T 268_Y 1.092 0.51
128_L 133_T 1.091 0.51
129_A 309_I 1.088 0.50
44_L 123_P 1.084 0.50
252_L 352_T 1.084 0.50
119_L 308_A 1.084 0.50
11_V 229_T 1.079 0.50
138_H 296_L 1.078 0.49
148_F 294_L 1.07 0.49
312_V 316_F 1.069 0.49
160_V 294_L 1.068 0.48
172_G 349_A 1.068 0.48
51_V 111_I 1.068 0.48
28_S 258_L 1.067 0.48
228_L 255_G 1.062 0.48
140_T 381_F 1.06 0.48
48_A 92_R 1.057 0.47
111_I 285_L 1.053 0.47
26_S 31_K 1.053 0.47
300_A 303_A 1.045 0.46
227_C 367_S 1.044 0.46
114_G 118_L 1.044 0.46
334_D 351_P 1.043 0.46
392_L 398_I 1.038 0.45
130_G 286_F 1.038 0.45
97_F 131_S 1.036 0.45
29_F 315_I 1.035 0.45
302_L 305_P 1.033 0.45
66_L 290_A 1.033 0.45
145_S 153_G 1.032 0.45
304_L 382_I 1.026 0.44
17_L 287_L 1.026 0.44
178_P 370_A 1.025 0.44
353_A 383_D 1.025 0.44
142_A 290_A 1.024 0.44
134_L 316_F 1.022 0.44
171_L 314_T 1.021 0.44
49_L 53_K 1.021 0.44
129_A 164_C 1.018 0.43
392_L 399_F 1.018 0.43
161_A 281_V 1.017 0.43
335_A 344_G 1.017 0.43
16_T 45_V 1.016 0.43
353_A 356_N 1.015 0.43
140_T 386_N 1.015 0.43
151_R 308_A 1.015 0.43
136_G 140_T 1.012 0.43
203_F 210_R 1.01 0.43
199_V 202_A 1.007 0.42
340_A 344_G 1.007 0.42
181_R 185_K 1.006 0.42
104_L 320_Y 1.005 0.42
40_A 290_A 1.004 0.42
70_L 73_A 1.002 0.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4bwzA10.860395.60.943Contact Map0.178
3zuxA10.778193.30.95Contact Map0.242
4dx5A30.44148.90.977Contact Map0.372
1zcdA20.44648.20.978Contact Map0.222
2nwlA30.72575.90.979Contact Map0.254
2nq2A20.21954.10.981Contact Map0.218
4k0jA60.44642.80.982Contact Map0.427
3w9iA60.42142.70.982Contact Map0.336
2l6wA20.09482.10.983Contact Map0.865
4g1uA20.21952.10.983Contact Map0.254
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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