OPENSEQ.org - FUCM - ECOLI GREMLIN

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FUCM - L-fucose mutarotase

UniProt:	P0AEN8	Sequence MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG10355
Length:	140 (140)
Sequences:	667
Seq/Len:	4.76

FUCM
Paralog alert: 0.40 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: FUCM RBSD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
13_L	121_V	4.396	1.00
27_I	117_A	4.109	1.00
15_K	19_E	2.7	1.00
16_V	119_A	2.687	1.00
112_E	115_Q	2.292	1.00
25_E	113_R	2.1	1.00
59_P	92_A	2.083	1.00
12_E	41_Q	2.009	1.00
15_K	41_Q	1.972	1.00
25_E	135_K	1.927	1.00
35_A	42_V	1.899	1.00
70_L	135_K	1.678	0.99
109_A	112_E	1.625	0.99
27_I	33_F	1.623	0.99
86_E	104_R	1.572	0.99
26_I	61_F	1.558	0.99
17_L	64_D	1.551	0.99
52_D	55_Q	1.551	0.99
20_M	65_S	1.52	0.99
43_I	119_A	1.51	0.98
23_G	33_F	1.471	0.98
85_V	130_G	1.436	0.98
2_L	64_D	1.43	0.98
14_L	18_A	1.405	0.97
26_I	119_A	1.402	0.97
114_A	120_I	1.396	0.97
50_V	55_Q	1.381	0.97
25_E	133_L	1.365	0.96
47_G	60_L	1.357	0.96
11_P	42_V	1.351	0.96
20_M	136_K	1.333	0.96
20_M	26_I	1.322	0.96
24_D	118_F	1.317	0.95
27_I	110_F	1.308	0.95
87_R	91_N	1.294	0.95
20_M	24_D	1.278	0.94
33_F	110_F	1.271	0.94
45_A	53_L	1.271	0.94
11_P	14_L	1.26	0.94
10_S	46_D	1.256	0.94
75_A	104_R	1.217	0.92
11_P	15_K	1.167	0.90
7_P	63_L	1.167	0.90
27_I	133_L	1.16	0.90
58_I	134_L	1.144	0.89
19_E	42_V	1.143	0.89
75_A	82_D	1.135	0.88
12_E	15_K	1.124	0.88
71_V	75_A	1.114	0.87
16_V	43_I	1.096	0.86
106_N	109_A	1.086	0.85
31_A	130_G	1.084	0.85
31_A	49_L	1.08	0.85
37_S	118_F	1.076	0.84
73_M	77_E	1.063	0.83
26_I	43_I	1.061	0.83
37_S	116_K	1.059	0.83
47_G	59_P	1.056	0.83
34_P	129_Y	1.055	0.83
16_V	26_I	1.052	0.82
32_H	122_I	1.04	0.81
110_F	114_A	1.019	0.80
55_Q	96_Q	1.016	0.79
28_F	121_V	1.014	0.79
91_N	109_A	1.014	0.79
14_L	17_L	1.014	0.79
125_E	129_Y	1.006	0.78

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
2wcuA	2	1	100	0.046	Contact Map	0.577
4a34A	20	0.9857	100	0.048	Contact Map	0.618
3mvkA	10	0.9929	100	0.058	Contact Map	0.614
2wcvA	10	0.9929	100	0.065	Contact Map	0.621
3dsaA	15	0.95	100	0.068	Contact Map	0.794
2ob5A	1	1	100	0.072	Contact Map	0.549
1ogdA	5	0.9214	100	0.088	Contact Map	0.629
3p12A	4	0.9286	100	0.089	Contact Map	0.649
3c3jA	6	0.7071	15.3	0.939	Contact Map	0.257
3j31Q	1	0.4	12	0.942	Contact Map	0.001

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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