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OPENSEQ.org
EXOX - Exodeoxyribonuclease 10
UniProt: P0AEK0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14031
Length: 220 (212)
Sequences: 654
Seq/Len: 3.08
EXOX
Paralog alert: 0.12 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
18_E 135_R 3.374 1.00
38_R 60_D 3.133 1.00
54_T 57_M 2.622 1.00
179_Y 191_D 2.512 1.00
43_I 58_V 2.426 1.00
47_A 51_H 2.376 1.00
208_E 211_L 2.35 1.00
42_P 55_E 2.313 1.00
40_D 63_W 2.296 1.00
113_S 116_A 2.28 1.00
3_R 21_S 2.201 1.00
48_M 54_T 2.114 1.00
17_V 51_H 2.027 1.00
37_V 67_V 1.907 0.99
64_I 68_I 1.902 0.99
79_A 82_A 1.882 0.99
32_P 141_Y 1.848 0.99
4_I 143_T 1.82 0.99
20_A 34_S 1.733 0.99
47_A 50_I 1.726 0.99
51_H 135_R 1.707 0.98
80_H 99_T 1.69 0.98
21_S 71_Y 1.636 0.98
63_W 66_D 1.59 0.97
182_K 190_R 1.585 0.97
111_K 116_A 1.583 0.97
24_V 144_A 1.576 0.97
34_S 137_L 1.563 0.97
3_R 75_E 1.556 0.97
36_L 57_M 1.547 0.97
20_A 140_C 1.501 0.96
36_L 61_K 1.478 0.95
17_V 47_A 1.447 0.95
137_L 141_Y 1.429 0.94
5_I 77_Y 1.396 0.93
183_A 186_D 1.372 0.92
39_P 58_V 1.354 0.92
5_I 98_C 1.348 0.92
34_S 135_R 1.335 0.91
40_D 55_E 1.324 0.91
110_I 120_T 1.313 0.90
20_A 137_L 1.296 0.89
100_M 104_R 1.292 0.89
212_T 215_H 1.29 0.89
86_R 96_W 1.274 0.88
208_E 212_T 1.273 0.88
79_A 98_C 1.27 0.88
196_R 200_N 1.253 0.87
4_I 144_A 1.249 0.87
18_E 98_C 1.235 0.86
104_R 107_W 1.227 0.86
159_E 168_P 1.219 0.85
118_Y 142_I 1.215 0.85
45_P 49_A 1.207 0.84
109_G 112_Y 1.207 0.84
165_T 168_P 1.203 0.84
22_V 137_L 1.202 0.84
17_V 43_I 1.201 0.84
163_D 167_R 1.195 0.83
18_E 34_S 1.191 0.83
206_S 211_L 1.187 0.83
46_Q 49_A 1.173 0.82
17_V 135_R 1.161 0.81
46_Q 50_I 1.161 0.81
137_L 140_C 1.14 0.79
56_A 157_T 1.138 0.79
115_M 133_H 1.132 0.79
12_L 51_H 1.128 0.78
143_T 146_L 1.117 0.77
80_H 103_A 1.116 0.77
144_A 148_I 1.114 0.77
186_D 190_R 1.114 0.77
103_A 112_Y 1.101 0.76
32_P 137_L 1.098 0.76
118_Y 123_L 1.098 0.76
14_G 88_V 1.08 0.74
23_D 75_E 1.078 0.74
194_Y 197_W 1.077 0.74
48_M 55_E 1.073 0.73
9_T 81_N 1.066 0.72
42_P 45_P 1.065 0.72
107_W 121_R 1.063 0.72
133_H 138_Y 1.062 0.72
50_I 193_G 1.051 0.71
64_I 67_V 1.047 0.71
209_L 213_L 1.047 0.71
82_A 98_C 1.045 0.70
82_A 96_W 1.043 0.70
17_V 36_L 1.032 0.69
44_S 55_E 1.029 0.69
9_T 84_F 1.024 0.68
21_S 33_M 1.02 0.68
82_A 92_M 1.019 0.68
43_I 47_A 1.013 0.67
206_S 212_T 1.013 0.67
20_A 146_L 1.013 0.67
76_W 97_I 1.009 0.66
35_H 61_K 1.008 0.66
183_A 198_L 1.007 0.66
37_V 61_K 1.006 0.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4fzxC20.79551000.465Contact Map0.716
2qxfA10.97731000.473Contact Map0.536
1zbuA40.84091000.482Contact Map0.654
4hxhB20.86361000.496Contact Map0.645
3cg7A20.90451000.499Contact Map0.62
2xriA10.72731000.5Contact Map0.632
1w0hA10.71821000.504Contact Map0.642
3mxmB20.81000.506Contact Map0.603
2p1jA20.71361000.513Contact Map0.733
2guiA10.72731000.517Contact Map0.687
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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