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OPENSEQ.org
DSBA - Thiol:disulfide interchange protein DsbA
UniProt: P0AEG4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11297
Length: 208 (204)
Sequences: 605
Seq/Len: 2.97
DSBA
Paralog alert: 0.40 [within 20: 0.04] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
137_K 140_E 2.798 1.00
46_S 91_L 2.636 1.00
22_Y 203_Y 2.374 1.00
24_D 30_T 2.205 1.00
113_E 117_K 2.164 1.00
128_R 142_D 2.138 1.00
129_D 138_G 2.055 1.00
99_M 153_L 1.986 1.00
93_Q 151_K 1.96 1.00
138_G 142_D 1.837 0.99
94_A 131_F 1.766 0.99
198_A 202_K 1.745 0.99
94_A 111_L 1.734 0.99
128_R 132_I 1.72 0.98
172_M 201_V 1.684 0.98
97_V 144_A 1.67 0.98
48_F 91_L 1.667 0.98
171_A 179_Q 1.648 0.98
40_Q 76_T 1.645 0.98
94_A 98_A 1.626 0.98
116_Q 169_V 1.601 0.97
140_E 143_A 1.593 0.97
101_L 136_I 1.581 0.97
25_G 203_Y 1.561 0.97
96_A 157_Q 1.558 0.97
124_A 146_N 1.527 0.96
22_Y 200_T 1.526 0.96
103_V 136_I 1.516 0.96
98_A 131_F 1.497 0.96
81_N 92_T 1.476 0.95
28_Y 207_K 1.462 0.95
46_S 169_V 1.46 0.95
82_F 169_V 1.446 0.94
5_W 8_L 1.438 0.94
148_F 152_S 1.43 0.94
98_A 103_V 1.429 0.94
129_D 133_N 1.416 0.93
29_T 179_Q 1.401 0.93
166_L 171_A 1.397 0.93
155_A 159_K 1.39 0.93
6_L 10_G 1.371 0.92
47_F 79_H 1.37 0.92
51_H 168_G 1.37 0.92
50_P 168_G 1.355 0.91
5_W 12_V 1.336 0.91
43_E 51_H 1.335 0.90
89_K 93_Q 1.332 0.90
139_E 143_A 1.328 0.90
128_R 138_G 1.327 0.90
111_L 127_I 1.323 0.90
149_V 152_S 1.312 0.89
55_F 172_M 1.312 0.89
195_Q 199_D 1.308 0.89
151_K 155_A 1.287 0.88
51_H 169_V 1.285 0.88
10_G 13_L 1.265 0.87
46_S 80_V 1.264 0.87
59_L 75_M 1.258 0.87
98_A 111_L 1.25 0.86
53_Y 117_K 1.247 0.86
101_L 144_A 1.237 0.85
69_L 201_V 1.236 0.85
50_P 169_V 1.219 0.84
148_F 156_Q 1.217 0.84
80_V 87_L 1.208 0.84
135_G 150_V 1.19 0.82
72_G 174_V 1.188 0.82
66_K 77_K 1.15 0.79
31_L 34_P 1.149 0.79
79_H 96_A 1.149 0.79
198_A 201_V 1.148 0.79
129_D 177_K 1.134 0.78
10_G 16_S 1.103 0.75
135_G 147_S 1.098 0.75
44_F 80_V 1.087 0.74
130_V 134_A 1.081 0.73
75_M 169_V 1.079 0.73
182_P 200_T 1.076 0.72
47_F 108_T 1.076 0.72
50_P 54_Q 1.063 0.71
90_D 145_W 1.063 0.71
4_I 10_G 1.061 0.71
140_E 144_A 1.057 0.71
31_L 145_W 1.051 0.70
95_W 99_M 1.049 0.70
22_Y 27_Q 1.038 0.69
98_A 101_L 1.035 0.68
8_L 11_L 1.031 0.68
87_L 92_T 1.03 0.68
66_K 69_L 1.027 0.67
203_Y 206_E 1.024 0.67
136_I 141_Y 1.006 0.65
77_K 169_V 1.003 0.65
42_L 78_Y 1.003 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3l9vA50.88461000.463Contact Map0.585
3l9sA10.90381000.469Contact Map0.558
3c7mA20.8511000.511Contact Map0.466
3feuA10.84621000.512Contact Map0.485
4jrrA30.87021000.513Contact Map0.656
4dvcA10.87981000.516Contact Map0.628
3hz8A10.8511000.525Contact Map0.529
2znmA40.84621000.528Contact Map0.545
3hd5A30.86541000.529Contact Map0.589
3h93A10.87021000.531Contact Map0.58
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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