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OPENSEQ.org
CYSG - Siroheme synthase
UniProt: P0AEA8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10188
Length: 457 (455)
Sequences: 609
Seq/Len: 1.34
CYSG
Paralog alert: 0.11 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
336_C 411_G 4.804 1.00
65_F 92_A 3.617 1.00
71_D 96_R 3.534 1.00
17_I 28_A 3.144 1.00
219_V 238_Q 2.679 1.00
45_F 60_L 2.654 1.00
17_I 38_L 2.615 1.00
409_E 417_R 2.533 1.00
218_V 317_L 2.445 1.00
316_T 320_A 2.392 0.99
221_V 297_V 2.347 0.99
147_L 151_L 2.305 0.99
16_L 73_C 2.297 0.99
28_A 49_F 2.268 0.99
288_R 292_K 2.097 0.98
393_K 396_E 2.048 0.98
160_Q 201_T 2.027 0.98
25_E 46_I 1.954 0.97
4_L 113_M 1.888 0.96
289_E 292_K 1.883 0.96
408_V 440_I 1.87 0.96
399_M 403_M 1.866 0.96
387_A 426_L 1.849 0.95
63_G 69_L 1.835 0.95
246_V 289_E 1.822 0.95
380_F 383_G 1.743 0.93
249_R 271_R 1.733 0.93
10_L 15_C 1.701 0.92
421_G 425_Q 1.688 0.92
284_Q 288_R 1.681 0.91
105_A 108_A 1.679 0.91
387_A 421_G 1.662 0.91
342_I 406_A 1.636 0.90
305_F 310_G 1.631 0.90
41_N 71_D 1.623 0.89
239_I 259_V 1.602 0.89
14_D 39_T 1.597 0.88
17_I 24_A 1.59 0.88
33_D 257_N 1.578 0.88
13_R 74_W 1.575 0.88
81_D 86_N 1.573 0.87
335_G 412_T 1.565 0.87
28_A 38_L 1.56 0.87
407_I 437_S 1.542 0.86
87_Q 91_E 1.536 0.86
245_V 259_V 1.534 0.86
380_F 441_I 1.533 0.86
85_L 89_V 1.525 0.85
41_N 69_L 1.524 0.85
287_L 316_T 1.499 0.84
401_G 424_T 1.498 0.84
15_C 113_M 1.483 0.83
74_W 97_R 1.474 0.82
67_E 88_R 1.471 0.82
6_I 111_F 1.469 0.82
410_N 415_T 1.469 0.82
8_C 99_F 1.454 0.81
80_T 86_N 1.454 0.81
50_T 54_D 1.444 0.81
223_A 255_I 1.437 0.80
337_S 440_I 1.436 0.80
354_R 380_F 1.435 0.80
410_N 413_A 1.433 0.80
78_A 86_N 1.43 0.80
339_Y 416_Q 1.428 0.80
229_G 234_K 1.409 0.78
90_S 109_A 1.4 0.78
405_V 426_L 1.398 0.77
229_G 237_Q 1.389 0.77
18_V 89_V 1.386 0.77
53_A 58_L 1.38 0.76
389_T 392_Q 1.379 0.76
306_I 334_S 1.377 0.76
254_D 414_V 1.373 0.76
260_R 381_Y 1.369 0.75
367_D 373_A 1.365 0.75
235_G 330_I 1.359 0.75
238_Q 327_V 1.35 0.74
131_T 159_G 1.346 0.74
23_V 80_T 1.345 0.74
306_I 353_V 1.335 0.73
138_L 185_N 1.334 0.73
234_K 238_Q 1.33 0.72
391_Q 395_I 1.329 0.72
392_Q 396_E 1.312 0.71
266_V 289_E 1.305 0.70
132_S 255_I 1.301 0.70
124_V 143_L 1.284 0.69
21_G 80_T 1.278 0.68
152_G 155_A 1.276 0.68
239_I 297_V 1.272 0.67
65_F 76_A 1.271 0.67
291_Q 320_A 1.271 0.67
281_E 284_Q 1.27 0.67
268_V 277_V 1.256 0.66
70_L 96_R 1.243 0.65
196_D 199_A 1.236 0.64
395_I 400_P 1.235 0.64
90_S 102_V 1.228 0.64
5_P 125_A 1.223 0.63
143_L 147_L 1.218 0.63
12_D 37_R 1.207 0.62
378_L 394_L 1.201 0.61
219_V 297_V 1.197 0.61
228_A 235_G 1.19 0.60
161_L 188_L 1.189 0.60
405_V 432_Q 1.188 0.60
227_D 234_K 1.186 0.60
117_I 126_V 1.184 0.59
65_F 96_R 1.184 0.59
336_C 380_F 1.181 0.59
28_A 58_L 1.179 0.59
116_I 261_R 1.178 0.59
65_F 89_V 1.171 0.58
53_A 60_L 1.166 0.58
88_R 91_E 1.163 0.57
219_V 295_R 1.162 0.57
305_F 314_L 1.161 0.57
395_I 402_E 1.16 0.57
114_P 125_A 1.16 0.57
334_S 353_V 1.16 0.57
244_V 289_E 1.159 0.57
384_L 437_S 1.157 0.57
17_I 186_D 1.154 0.56
236_L 240_Q 1.153 0.56
39_T 73_C 1.152 0.56
198_K 209_N 1.149 0.56
339_Y 412_T 1.145 0.55
305_F 341_G 1.145 0.55
294_K 426_L 1.144 0.55
284_Q 424_T 1.143 0.55
76_A 253_D 1.142 0.55
103_V 262_D 1.14 0.55
34_A 126_V 1.139 0.55
336_C 407_I 1.136 0.55
265_R 282_I 1.134 0.54
74_W 99_F 1.129 0.54
355_L 381_Y 1.123 0.53
20_G 49_F 1.123 0.53
354_R 378_L 1.123 0.53
244_V 266_V 1.117 0.53
164_R 205_E 1.116 0.53
132_S 349_Y 1.113 0.52
39_T 59_T 1.11 0.52
3_H 112_I 1.1 0.51
38_L 58_L 1.099 0.51
332_A 381_Y 1.098 0.51
188_L 192_L 1.097 0.51
122_L 211_P 1.096 0.51
32_L 58_L 1.093 0.50
32_L 52_W 1.091 0.50
356_I 441_I 1.087 0.50
78_A 85_L 1.084 0.49
9_Q 62_E 1.082 0.49
88_R 92_A 1.081 0.49
362_T 365_E 1.076 0.49
151_L 233_L 1.075 0.48
27_K 103_V 1.07 0.48
23_V 26_R 1.069 0.48
358_G 390_I 1.063 0.47
403_M 443_R 1.059 0.47
234_K 327_V 1.058 0.47
42_A 291_Q 1.055 0.46
419_I 433_M 1.051 0.46
217_E 325_S 1.049 0.46
52_W 57_M 1.043 0.45
18_V 126_V 1.043 0.45
405_V 427_G 1.043 0.45
138_L 141_E 1.04 0.45
223_A 251_V 1.04 0.45
179_W 358_G 1.039 0.45
359_H 368_W 1.039 0.45
148_P 179_W 1.037 0.45
14_D 73_C 1.036 0.45
315_E 450_K 1.035 0.44
125_A 354_R 1.034 0.44
49_F 76_A 1.028 0.44
421_G 426_L 1.026 0.44
231_L 255_I 1.023 0.43
198_K 206_Q 1.019 0.43
54_D 408_V 1.014 0.42
285_I 289_E 1.014 0.42
99_F 110_S 1.014 0.42
16_L 65_F 1.013 0.42
124_V 168_Q 1.013 0.42
354_R 376_Q 1.013 0.42
45_F 62_E 1.013 0.42
156_K 160_Q 1.013 0.42
249_R 267_F 1.013 0.42
231_L 235_G 1.012 0.42
217_E 295_R 1.011 0.42
238_Q 325_S 1.007 0.42
115_S 141_E 1.006 0.42
16_L 70_L 1.006 0.42
251_V 255_I 1.005 0.42
386_Q 437_S 1.005 0.42
399_M 443_R 1.005 0.42
368_W 371_L 1.004 0.41
407_I 413_A 1.003 0.41
353_V 380_F 1.003 0.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pjqA211000.32Contact Map0.671
2yboA10.58211000.666Contact Map0.624
1s4dA120.55581000.667Contact Map0.656
1ve2A20.5121000.691Contact Map0.636
4e16A10.5231000.698Contact Map0.595
1cbfA10.55581000.701Contact Map0.546
1va0A20.49671000.703Contact Map0.69
3ndcA20.52081000.707Contact Map0.571
1wyzA40.50331000.725Contact Map0.551
3i4tA10.55361000.727Contact Map0.408
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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