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OPENSEQ.org

YTFP - Gamma-glutamylcyclotransferase family protein YtfP
UniProt: P0AE48 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12516
Length: 113 (111)
Sequences: 483
Seq/Len: 4.35

YTFP
Paralog alert: 0.02 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
10_R 107_D 4.322 1.00
55_V 88_A 2.904 1.00
4_F 53_G 2.759 1.00
15_N 69_L 2.678 1.00
3_I 66_L 2.081 1.00
23_Q 57_R 1.918 1.00
69_L 89_W 1.915 1.00
30_I 44_A 1.873 1.00
11_H 54_E 1.863 1.00
63_L 78_R 1.842 1.00
10_R 109_L 1.789 1.00
67_D 70_R 1.67 0.99
72_R 77_A 1.594 0.99
3_I 15_N 1.594 0.99
37_S 108_W 1.543 0.98
36_Y 106_G 1.527 0.98
83_T 86_G 1.512 0.98
3_I 69_L 1.503 0.98
41_Y 75_E 1.495 0.98
39_G 108_W 1.44 0.97
59_D 62_T 1.433 0.97
83_T 88_A 1.391 0.96
78_R 89_W 1.374 0.96
26_G 56_Y 1.348 0.95
19_M 22_A 1.34 0.95
15_N 108_W 1.295 0.94
32_N 43_G 1.284 0.94
13_Q 108_W 1.265 0.93
24_L 56_Y 1.264 0.93
51_V 90_M 1.249 0.92
41_Y 71_T 1.222 0.91
6_Y 9_L 1.16 0.88
51_V 71_T 1.157 0.88
80_L 87_S 1.116 0.85
31_D 48_N 1.091 0.84
22_A 56_Y 1.089 0.83
97_V 103_I 1.079 0.83
28_F 86_G 1.069 0.82
68_A 71_T 1.063 0.81
44_A 92_V 1.047 0.80
32_N 51_V 1.044 0.80
11_H 24_L 1.033 0.79
16_S 54_E 1.02 0.77
75_E 93_Y 1.018 0.77
3_I 72_R 1.018 0.77
12_K 47_G 1.014 0.77
36_Y 45_V 1 0.75
38_L 43_G 1 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1xhsA111000.213Contact Map0.331
1v30A10.97351000.231Contact Map0.533
2qikA10.902799.90.307Contact Map0.573
1vkbA10.982399.90.313Contact Map0.533
4gysA2099.90.357Contact Map
4issA20.973599.80.411Contact Map0.386
2g0qA10.955899.80.433Contact Map0.393
2jqvA10.955899.80.468Contact Map0.296
3judA10.982399.70.478Contact Map0.533
3cryA20.973599.60.54Contact Map0.451

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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