OPENSEQ.org - YHEV - ECOLI GREMLIN

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YHEV - Uncharacterized protein YheV

UniProt:	P0ADW8	Sequence MAIRKRFIAGAKCPACQAQDSMAMWRENNIDIVECVKCGHQMREADKEARDHVRKDEQVIGIFHPD	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG14364
Length:	66 (66)
Sequences:	96
Seq/Len:	1.45

YHEV
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
8_I	22_M	2.154	0.99
4_R	64_H	2.145	0.99
61_G	65_P	2.14	0.99
54_R	57_E	1.646	0.91
25_W	62_I	1.637	0.91
15_A	47_K	1.57	0.89
30_I	49_A	1.502	0.86
31_D	64_H	1.474	0.84
4_R	31_D	1.427	0.81
39_G	42_M	1.365	0.77
22_M	25_W	1.347	0.76
21_S	32_I	1.322	0.74
50_R	66_D	1.32	0.74
5_K	22_M	1.317	0.74
24_M	31_D	1.22	0.65
28_N	47_K	1.204	0.64
19_Q	45_A	1.204	0.64
49_A	57_E	1.187	0.62
24_M	44_E	1.164	0.60
4_R	46_D	1.154	0.59
22_M	33_V	1.133	0.57
12_K	17_Q	1.128	0.56
17_Q	66_D	1.128	0.56
30_I	59_V	1.118	0.55
54_R	59_V	1.113	0.55
18_A	46_D	1.111	0.54
18_A	51_D	1.093	0.53
12_K	43_R	1.066	0.50
31_D	65_P	1.062	0.49
31_D	49_A	1.052	0.48
8_I	42_M	1.048	0.48
4_R	37_K	1.036	0.47
1_M	55_K	1.006	0.44
53_V	58_Q	1.004	0.44
48_E	54_R	1	0.43

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
1neeA	1	0.697	75.2	0.866	Contact Map	0
3cw2K	4	0.697	73.7	0.868	Contact Map	0.148
2d74B	1	0.8182	71.7	0.87	Contact Map	0.076
2k4xA	1	0.6364	71.2	0.87	Contact Map	0.066
3fo3A	2	1	69.5	0.872	Contact Map	0.003
3j21g	1	0.7121	65.9	0.875	Contact Map	0.097
3ga8A	1	0.8485	62.9	0.877	Contact Map	0.051
2e9hA	1	0.9091	61.2	0.878	Contact Map	0.071
1nuiA	2	0.9545	59	0.88	Contact Map	0.122
1k81A	1	0.5455	57.3	0.881	Contact Map	0

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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