May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YHCC - Uncharacterized protein YhcC
UniProt: P0ADW6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12809
Length: 309 (298)
Sequences: 1038
Seq/Len: 3.48
YHCC
Paralog alert: 0.10 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
128_D 176_R 3.493 1.00
162_D 165_C 3.155 1.00
174_R 209_D 3.142 1.00
184_L 199_T 2.852 1.00
46_T 227_A 2.796 1.00
98_R 132_E 2.76 1.00
250_R 295_V 2.692 1.00
168_R 172_L 2.648 1.00
289_Y 293_H 2.552 1.00
151_D 163_F 2.454 1.00
151_D 164_A 2.404 1.00
142_L 173_A 2.386 1.00
166_Y 182_S 2.341 1.00
237_E 240_D 2.34 1.00
201_E 251_H 2.311 1.00
124_D 172_L 2.263 1.00
94_V 98_R 2.239 1.00
64_A 103_Q 2.198 1.00
246_G 287_D 2.13 1.00
185_I 216_L 2.084 1.00
46_T 224_M 2.083 1.00
144_L 173_A 2.076 1.00
289_Y 292_E 2.053 1.00
173_A 180_V 2.038 1.00
204_V 253_P 2.034 1.00
8_N 16_R 2.016 1.00
150_H 198_Q 2.004 1.00
193_Q 247_E 1.994 1.00
8_N 12_G 1.992 1.00
225_A 271_L 1.974 1.00
186_V 248_M 1.924 1.00
150_H 195_E 1.827 0.99
200_L 248_M 1.812 0.99
250_R 293_H 1.789 0.99
20_Q 79_R 1.74 0.99
174_R 207_G 1.73 0.99
198_Q 201_E 1.725 0.99
227_A 232_R 1.716 0.99
156_R 227_A 1.715 0.99
247_E 250_R 1.715 0.99
6_L 294_G 1.685 0.99
193_Q 243_L 1.654 0.99
94_V 129_L 1.601 0.98
146_L 166_Y 1.578 0.98
98_R 136_Q 1.555 0.98
129_L 133_Y 1.541 0.97
226_K 230_A 1.519 0.97
171_Q 175_Q 1.518 0.97
101_Y 113_L 1.496 0.97
84_F 104_A 1.485 0.96
278_N 281_T 1.474 0.96
80_Y 111_V 1.465 0.96
220_K 229_E 1.45 0.96
210_G 259_H 1.449 0.96
294_G 298_S 1.436 0.96
117_T 142_L 1.434 0.95
167_Q 171_Q 1.425 0.95
104_A 110_I 1.423 0.95
182_S 208_V 1.418 0.95
250_R 298_S 1.401 0.95
114_C 141_W 1.39 0.94
173_A 178_L 1.388 0.94
167_Q 202_R 1.383 0.94
102_Q 133_Y 1.38 0.94
172_L 176_R 1.375 0.94
246_G 289_Y 1.365 0.94
146_L 182_S 1.365 0.94
102_Q 136_Q 1.364 0.94
288_R 292_E 1.322 0.92
170_T 180_V 1.321 0.92
236_I 244_T 1.309 0.92
157_I 188_L 1.299 0.91
295_V 298_S 1.295 0.91
183_H 214_H 1.295 0.91
34_P 121_C 1.287 0.91
148_T 153_T 1.283 0.91
96_V 99_S 1.266 0.90
243_L 289_Y 1.256 0.89
164_A 168_R 1.25 0.89
153_T 189_P 1.249 0.89
247_E 293_H 1.246 0.89
123_P 126_V 1.236 0.88
88_T 121_C 1.225 0.88
5_K 12_G 1.223 0.88
64_A 68_A 1.212 0.87
41_G 160_G 1.203 0.86
63_I 104_A 1.202 0.86
146_L 203_V 1.194 0.86
10_F 14_L 1.178 0.85
71_A 109_N 1.168 0.84
131_C 176_R 1.161 0.84
203_V 252_T 1.151 0.83
98_R 102_Q 1.145 0.83
197_L 247_E 1.145 0.83
5_K 287_D 1.142 0.82
179_K 209_D 1.142 0.82
40_I 43_G 1.142 0.82
96_V 100_M 1.139 0.82
242_T 285_E 1.139 0.82
204_V 252_T 1.138 0.82
167_Q 206_T 1.135 0.82
172_L 175_Q 1.133 0.82
142_L 178_L 1.133 0.82
184_L 203_V 1.133 0.82
289_Y 295_V 1.131 0.82
119_P 260_R 1.13 0.81
183_H 212_K 1.126 0.81
127_L 176_R 1.123 0.81
143_E 183_H 1.123 0.81
155_H 162_D 1.114 0.80
8_N 25_L 1.113 0.80
185_I 217_H 1.111 0.80
62_S 65_E 1.102 0.79
17_R 179_K 1.093 0.78
85_Q 214_H 1.09 0.78
13_D 17_R 1.089 0.78
151_D 155_H 1.087 0.78
143_E 214_H 1.08 0.77
71_A 108_A 1.078 0.77
193_Q 197_L 1.063 0.76
192_G 195_E 1.062 0.76
218_I 224_M 1.06 0.75
218_I 225_A 1.058 0.75
85_Q 260_R 1.058 0.75
250_R 289_Y 1.058 0.75
68_A 72_N 1.056 0.75
163_F 167_Q 1.055 0.75
65_E 68_A 1.055 0.75
8_N 13_D 1.053 0.75
37_D 158_N 1.042 0.74
18_Y 139_E 1.04 0.73
4_Q 12_G 1.038 0.73
280_W 284_V 1.032 0.73
46_T 156_R 1.032 0.73
200_L 204_V 1.03 0.72
20_Q 78_K 1.024 0.72
202_R 205_E 1.024 0.72
40_I 165_C 1.023 0.72
10_F 259_H 1.022 0.71
225_A 229_E 1.016 0.71
152_K 155_H 1.013 0.71
82_A 110_I 1.012 0.70
82_A 104_A 1.006 0.70
218_I 222_S 1 0.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1oltA10.9451000.648Contact Map0.573
4jc0A20.9321000.692Contact Map0.588
2qgqA80.8771000.701Contact Map0.714
1r30A20.8999.90.722Contact Map0.601
3iixA10.912699.90.728Contact Map0.593
3t7vA10.886799.90.739Contact Map0.589
4fhdA10.783299.80.771Contact Map0.414
1tv8A20.857699.80.778Contact Map0.577
2a5hA40.880399.70.805Contact Map0.521
3c8fA10.757399.70.805Contact Map0.516
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0371 seconds.