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OPENSEQ.org
MLAC - Probable phospholipid-binding protein MlaC
UniProt: P0ADV7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12798
Length: 211 (208)
Sequences: 627
Seq/Len: 3.01
MLAC
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
89_Q 191_D 3.987 1.00
74_G 93_Y 2.852 1.00
165_D 172_S 2.241 1.00
78_L 93_Y 2.048 1.00
191_D 194_T 1.808 0.99
96_A 201_S 1.792 0.99
10_L 18_A 1.776 0.99
88_A 92_A 1.729 0.99
87_P 90_R 1.722 0.99
32_D 36_Q 1.71 0.98
96_A 198_K 1.675 0.98
92_A 198_K 1.626 0.98
68_V 166_M 1.581 0.97
69_Q 153_R 1.57 0.97
151_Q 165_D 1.526 0.96
177_K 180_E 1.469 0.95
5_L 17_S 1.436 0.94
72_Y 75_A 1.43 0.94
76_L 174_I 1.43 0.94
82_Y 90_R 1.406 0.93
5_L 12_V 1.366 0.92
172_S 175_T 1.351 0.91
33_E 37_K 1.33 0.90
150_F 161_W 1.324 0.90
77_V 93_Y 1.316 0.90
134_R 149_D 1.306 0.89
112_Y 172_S 1.297 0.89
85_A 190_I 1.297 0.89
42_L 109_L 1.293 0.89
68_V 172_S 1.293 0.89
10_L 13_I 1.291 0.89
9_A 17_S 1.281 0.88
167_I 172_S 1.273 0.88
8_V 13_I 1.262 0.87
12_V 21_A 1.262 0.87
72_Y 76_L 1.262 0.87
8_V 12_V 1.258 0.87
112_Y 115_Q 1.254 0.87
6_M 12_V 1.254 0.87
89_Q 194_T 1.252 0.87
81_Y 182_G 1.243 0.86
4_R 9_A 1.241 0.86
9_A 14_A 1.237 0.86
78_L 172_S 1.236 0.86
118_Q 136_T 1.228 0.85
195_A 199_S 1.225 0.85
8_V 17_S 1.221 0.85
185_L 189_G 1.198 0.83
13_I 18_A 1.197 0.83
86_T 89_Q 1.196 0.83
61_D 98_R 1.195 0.83
135_V 148_L 1.171 0.81
36_Q 40_D 1.17 0.81
169_E 172_S 1.169 0.81
11_L 19_A 1.164 0.81
13_I 16_L 1.153 0.80
109_L 180_E 1.151 0.80
9_A 12_V 1.149 0.79
60_V 161_W 1.144 0.79
4_R 14_A 1.141 0.79
4_R 11_L 1.135 0.78
8_V 21_A 1.135 0.78
2_F 9_A 1.131 0.78
188_K 196_Q 1.13 0.78
151_Q 172_S 1.129 0.78
6_M 16_L 1.128 0.78
135_V 165_D 1.128 0.78
78_L 185_L 1.122 0.77
74_G 104_A 1.12 0.77
174_I 177_K 1.119 0.77
41_R 63_E 1.116 0.77
68_V 163_A 1.112 0.76
3_K 9_A 1.104 0.76
11_L 20_T 1.101 0.75
2_F 18_A 1.098 0.75
91_E 95_A 1.091 0.74
108_A 121_P 1.087 0.74
3_K 8_V 1.085 0.74
7_M 13_I 1.078 0.73
76_L 175_T 1.071 0.72
10_L 20_T 1.067 0.72
88_A 91_E 1.067 0.72
3_K 16_L 1.063 0.72
6_M 15_P 1.063 0.72
8_V 14_A 1.061 0.71
2_F 208_E 1.059 0.71
7_M 20_T 1.047 0.70
30_L 67_Y 1.047 0.70
183_T 187_T 1.042 0.69
66_P 121_P 1.042 0.69
7_M 11_L 1.041 0.69
72_Y 153_R 1.031 0.68
8_V 20_T 1.023 0.67
95_A 98_R 1.022 0.67
26_N 29_K 1.02 0.67
15_P 18_A 1.018 0.67
38_T 49_I 1.006 0.65
8_V 18_A 1.006 0.65
6_M 9_A 1.005 0.65
11_L 14_A 1.001 0.65
100_Y 177_K 1 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2qguA10.97161000.113Contact Map0.674
4fczB20.96211000.126Contact Map0.563
4hz9B20.668283.40.914Contact Map0.487
4a3nA10.336563.40.927Contact Map0.556
2crjA10.431359.90.929Contact Map0.386
2cs1A10.431356.40.93Contact Map0.436
3zg1A40.483453.10.931Contact Map0.628
3u2bC10.374450.40.933Contact Map0.51
2lhjA10.412349.90.933Contact Map0.361
1hmeA10.336548.70.933Contact Map0.494
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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