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OPENSEQ.org
TAMA - Translocation and assembly module TamA
UniProt: P0ADE4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12513
Length: 577 (550)
Sequences: 2923
Seq/Len: 5.31
TAMA
Paralog alert: 0.76 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
107_G 178_F 4.351 1.00
447_T 504_L 4.341 1.00
192_G 255_P 4.253 1.00
103_P 136_V 3.721 1.00
195_T 257_T 3.522 1.00
520_V 536_T 3.473 1.00
271_G 283_K 3.227 1.00
196_F 206_L 3.204 1.00
443_H 506_Y 3.125 1.00
171_A 174_L 2.921 1.00
193_H 214_E 2.717 1.00
555_F 567_L 2.7 1.00
476_I 484_I 2.696 1.00
192_G 246_D 2.644 1.00
110_D 180_D 2.561 1.00
244_Q 257_T 2.559 1.00
296_H 315_Y 2.503 1.00
102_V 175_H 2.496 1.00
108_G 178_F 2.429 1.00
522_S 536_T 2.427 1.00
237_N 261_S 2.413 1.00
366_N 389_G 2.409 1.00
152_I 156_K 2.395 1.00
107_G 176_K 2.37 1.00
269_E 285_T 2.368 1.00
369_W 384_M 2.322 1.00
508_Y 516_G 2.271 1.00
430_Q 468_F 2.255 1.00
285_T 301_S 2.247 1.00
197_E 257_T 2.169 1.00
394_R 407_D 2.141 1.00
300_T 313_F 2.12 1.00
203_D 207_Q 2.115 1.00
452_G 468_F 2.092 1.00
519_F 539_G 2.079 1.00
475_S 501_T 2.062 1.00
153_A 185_S 2.061 1.00
197_E 259_V 2.044 1.00
426_F 466_L 2.041 1.00
273_G 281_R 2.034 1.00
538_T 559_V 1.985 1.00
454_I 462_V 1.973 1.00
518_V 540_V 1.939 1.00
553_L 569_F 1.935 1.00
517_A 543_R 1.926 1.00
192_G 253_V 1.905 1.00
155_R 221_K 1.904 1.00
299_T 314_S 1.899 1.00
296_H 317_M 1.889 1.00
543_R 554_D 1.858 1.00
108_G 133_I 1.845 1.00
219_E 222_D 1.843 1.00
287_K 299_T 1.827 1.00
192_G 247_K 1.825 1.00
266_N 288_K 1.82 1.00
432_Q 450_T 1.808 1.00
477_R 521_D 1.8 1.00
398_R 404_T 1.793 1.00
122_D 156_K 1.79 1.00
472_G 475_S 1.784 1.00
364_A 391_M 1.78 1.00
80_E 99_T 1.758 1.00
155_R 219_E 1.751 1.00
453_W 498_K 1.746 1.00
367_L 386_F 1.743 1.00
116_G 185_S 1.737 1.00
558_P 570_Y 1.704 1.00
330_V 353_R 1.703 1.00
265_E 288_K 1.698 1.00
193_H 255_P 1.694 1.00
105_L 136_V 1.679 1.00
407_D 435_W 1.679 1.00
171_A 178_F 1.676 1.00
409_Q 433_N 1.669 1.00
536_T 560_A 1.64 0.99
546_S 549_G 1.632 0.99
361_W 392_I 1.627 0.99
66_R 70_K 1.604 0.99
361_W 394_R 1.6 0.99
69_L 100_P 1.595 0.99
78_T 99_T 1.587 0.99
471_G 475_S 1.554 0.99
368_R 387_Y 1.554 0.99
213_K 216_D 1.55 0.99
198_G 262_P 1.533 0.99
188_R 217_E 1.532 0.99
62_D 96_A 1.529 0.99
147_K 151_S 1.529 0.99
196_F 207_Q 1.52 0.99
517_A 554_D 1.519 0.99
478_G 537_G 1.504 0.99
114_R 180_D 1.5 0.99
135_T 141_D 1.494 0.99
470_A 501_T 1.469 0.98
228_R 232_A 1.468 0.98
496_A 525_A 1.452 0.98
227_N 231_S 1.45 0.98
446_V 507_Q 1.432 0.98
328_Y 355_W 1.431 0.98
479_Y 560_A 1.429 0.98
476_I 537_G 1.404 0.98
87_P 91_R 1.4 0.98
223_L 256_L 1.4 0.98
350_V 368_R 1.396 0.98
541_G 554_D 1.379 0.97
334_F 347_T 1.375 0.97
524_E 534_F 1.374 0.97
116_G 120_D 1.373 0.97
517_A 541_G 1.354 0.97
242_A 259_V 1.352 0.97
144_N 148_S 1.343 0.97
72_L 138_N 1.338 0.97
117_A 185_S 1.334 0.97
211_P 226_L 1.333 0.97
443_H 508_Y 1.332 0.97
333_G 352_S 1.33 0.97
140_G 144_N 1.328 0.97
111_V 123_Y 1.327 0.97
479_Y 558_P 1.322 0.96
76_Q 104_V 1.32 0.96
220_S 224_A 1.319 0.96
357_L 363_R 1.315 0.96
151_S 155_R 1.315 0.96
201_I 262_P 1.312 0.96
160_D 189_Y 1.307 0.96
448_R 503_S 1.3 0.96
517_A 552_K 1.293 0.96
272_V 282_V 1.291 0.96
121_K 124_L 1.289 0.96
114_R 182_D 1.275 0.95
537_G 570_Y 1.27 0.95
522_S 534_F 1.264 0.95
107_G 133_I 1.262 0.95
120_D 124_L 1.261 0.95
284_A 302_T 1.254 0.95
110_D 114_R 1.246 0.95
503_S 521_D 1.244 0.94
317_M 320_L 1.244 0.94
437_R 447_T 1.243 0.94
435_W 447_T 1.243 0.94
414_D 428_V 1.242 0.94
216_D 222_D 1.229 0.94
241_V 258_G 1.229 0.94
76_Q 172_L 1.225 0.94
298_L 313_F 1.224 0.94
240_V 259_V 1.217 0.94
80_E 97_K 1.214 0.93
391_M 412_S 1.209 0.93
363_R 390_V 1.208 0.93
235_W 295_G 1.208 0.93
266_N 286_W 1.207 0.93
434_V 448_R 1.203 0.93
309_Q 336_R 1.198 0.93
396_R 407_D 1.197 0.93
469_F 495_G 1.195 0.93
141_D 144_N 1.195 0.93
104_V 177_A 1.191 0.93
484_I 524_E 1.188 0.93
262_P 293_S 1.186 0.92
554_D 570_Y 1.183 0.92
403_P 406_G 1.183 0.92
365_I 390_V 1.178 0.92
508_Y 518_V 1.174 0.92
63_D 66_R 1.174 0.92
121_K 125_K 1.172 0.92
137_L 142_Y 1.171 0.92
210_V 226_L 1.17 0.92
119_T 122_D 1.16 0.91
432_Q 448_R 1.156 0.91
473_D 570_Y 1.156 0.91
82_D 97_K 1.154 0.91
286_W 300_T 1.153 0.91
68_G 72_L 1.149 0.91
106_I 179_W 1.148 0.91
246_D 255_P 1.147 0.91
63_D 67_E 1.146 0.91
57_F 61_V 1.137 0.90
292_N 296_H 1.136 0.90
69_L 77_P 1.135 0.90
452_G 499_L 1.125 0.90
413_I 429_F 1.122 0.89
371_L 384_M 1.122 0.89
138_N 141_D 1.119 0.89
507_Q 515_W 1.119 0.89
36_E 40_R 1.117 0.89
291_M 298_L 1.117 0.89
446_V 505_E 1.114 0.89
395_T 408_S 1.11 0.89
479_Y 535_K 1.107 0.89
320_L 324_L 1.102 0.88
357_L 392_I 1.102 0.88
132_A 135_T 1.099 0.88
336_R 343_E 1.099 0.88
301_S 312_D 1.096 0.88
162_E 184_N 1.096 0.88
394_R 409_Q 1.095 0.88
407_D 433_N 1.094 0.88
59_A 62_D 1.093 0.88
275_S 278_V 1.092 0.88
485_A 493_L 1.091 0.88
345_D 373_H 1.089 0.87
71_A 138_N 1.089 0.87
510_V 516_G 1.086 0.87
198_G 478_G 1.082 0.87
358_S 361_W 1.082 0.87
211_P 229_R 1.08 0.87
408_S 434_V 1.079 0.87
409_Q 431_A 1.072 0.86
436_I 444_R 1.07 0.86
211_P 359_S 1.069 0.86
191_F 194_V 1.069 0.86
470_A 475_S 1.069 0.86
39_V 65_I 1.064 0.86
302_T 311_L 1.062 0.86
331_Q 352_S 1.059 0.85
430_Q 450_T 1.057 0.85
111_V 183_Y 1.054 0.85
237_N 263_R 1.053 0.85
37_K 41_A 1.052 0.85
297_S 316_K 1.051 0.85
290_W 293_S 1.049 0.85
163_F 181_I 1.047 0.85
29_E 33_G 1.045 0.84
312_D 333_G 1.037 0.84
28_V 39_V 1.036 0.84
64_A 67_E 1.031 0.83
338_D 343_E 1.031 0.83
124_L 127_L 1.03 0.83
479_Y 561_D 1.025 0.83
440_Y 443_H 1.015 0.82
445_F 504_L 1.014 0.82
446_V 517_A 1.012 0.82
516_G 542_V 1.011 0.82
71_A 140_G 1.011 0.82
447_T 506_Y 1.01 0.81
470_A 484_I 1.009 0.81
486_P 496_A 1.008 0.81
104_V 137_L 1.008 0.81
557_V 567_L 1.005 0.81
496_A 523_G 1.004 0.81
303_S 310_T 1 0.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4c00A10.96531000.176Contact Map0.727
4k3bA10.98091000.273Contact Map0.674
4k3cA10.80591000.335Contact Map0.658
2qdzA10.86661000.444Contact Map0.485
4bzaA10.45231000.668Contact Map0.687
2qdfA10.44711000.738Contact Map0.679
3efcA10.42461000.744Contact Map0.733
2x8xX10.39511000.759Contact Map0.524
3q6bA10.32411000.766Contact Map0.78
3mc9A20.43331000.77Contact Map0.65
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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