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OPENSEQ.org

RAIA - Ribosome-associated inhibitor A
UniProt: P0AD49 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11151
Length: 113 (99)
Sequences: 1112
Seq/Len: 11.23

RAIA
Paralog alert: 0.27 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: HPF RAIA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
67_H 73_A 4.018 1.00
41_L 50_A 2.312 1.00
16_I 70_M 2.292 1.00
18_Q 22_D 2.083 1.00
30_W 82_E 2.068 1.00
7_S 12_I 2.049 1.00
20_V 41_L 1.928 1.00
52_A 77_L 1.905 1.00
83_R 87_K 1.814 1.00
43_K 48_F 1.746 1.00
24_L 78_I 1.723 1.00
53_T 62_V 1.713 1.00
41_L 70_M 1.676 1.00
14_P 18_Q 1.66 1.00
29_K 82_E 1.609 1.00
19_H 74_I 1.557 1.00
44_E 49_V 1.487 1.00
70_M 74_I 1.408 1.00
12_I 17_R 1.391 0.99
56_T 85_L 1.34 0.99
19_H 72_T 1.33 0.99
65_G 76_E 1.318 0.99
49_V 66_K 1.297 0.99
48_F 70_M 1.294 0.99
13_T 16_I 1.262 0.99
86_N 90_H 1.249 0.99
51_D 62_V 1.24 0.98
10_M 70_M 1.238 0.98
7_S 13_T 1.228 0.98
63_A 77_L 1.221 0.98
10_M 71_Y 1.215 0.98
51_D 80_K 1.208 0.98
47_G 66_K 1.198 0.98
6_T 40_I 1.182 0.98
17_R 21_A 1.177 0.98
5_I 12_I 1.16 0.97
26_K 79_N 1.125 0.97
85_L 94_A 1.112 0.96
22_D 25_A 1.1 0.96
24_L 52_A 1.098 0.96
11_E 95_R 1.095 0.96
21_A 24_L 1.094 0.96
87_K 90_H 1.073 0.95
73_A 81_L 1.064 0.95
67_H 72_T 1.04 0.94
15_A 71_Y 1.039 0.94
6_T 38_H 1.038 0.94
49_V 64_S 1.03 0.94
37_P 54_I 1.014 0.93
56_T 88_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3v2cY111000.12Contact Map0.662
1imuA10.94691000.198Contact Map0.702
3tqmA40.84961000.213Contact Map0.715
4fylA20.84071000.222Contact Map0.739
3v26X10.89381000.223Contact Map0.444
2ywqA40.876199.90.232Contact Map0.882
3ku7A20.495615.50.917Contact Map0.486
1pu1A10.672615.10.917Contact Map0.223
3ghgA40.991214.40.918Contact Map0.209
1deqA40.991211.90.921Contact Map0.042

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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