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OPENSEQ.org

YFCA - UPF0721 transmembrane protein YfcA
UniProt: P0AD30 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11144
Length: 269 (249)
Sequences: 5220
Seq/Len: 20.96

YFCA
Paralog alert: 0.64 [within 20: 0.04] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
27_F 229_L 3.963 1.00
252_K 256_D 3.404 1.00
100_L 154_F 3.311 1.00
93_G 150_G 2.971 1.00
79_S 181_K 2.902 1.00
236_K 240_P 2.783 1.00
237_L 240_P 2.744 1.00
114_P 250_S 2.49 1.00
228_R 232_S 2.154 1.00
79_S 82_D 2.074 1.00
251_A 255_Y 2.051 1.00
30_S 33_G 2.027 1.00
234_G 237_L 1.971 1.00
21_V 42_A 1.913 1.00
81_S 84_K 1.91 1.00
73_I 80_L 1.879 1.00
121_G 250_S 1.875 1.00
23_M 222_G 1.856 1.00
67_S 220_F 1.792 1.00
122_L 126_L 1.734 1.00
19_F 218_G 1.728 1.00
99_L 103_Y 1.693 1.00
178_N 181_K 1.692 1.00
93_G 97_G 1.686 1.00
115_I 119_C 1.674 1.00
56_T 212_G 1.668 1.00
58_K 197_G 1.636 1.00
118_I 250_S 1.635 1.00
59_L 212_G 1.615 1.00
52_N 55_A 1.569 1.00
87_I 192_T 1.555 1.00
63_G 216_L 1.549 1.00
83_Q 188_L 1.546 1.00
114_P 257_S 1.525 1.00
72_F 77_V 1.507 1.00
121_G 247_A 1.497 1.00
67_S 224_R 1.479 1.00
81_S 85_L 1.454 1.00
22_A 215_M 1.454 1.00
224_R 228_R 1.453 1.00
25_A 38_L 1.452 1.00
23_M 225_M 1.44 1.00
116_L 159_F 1.437 1.00
83_Q 185_H 1.434 1.00
23_M 221_L 1.432 1.00
78_V 185_H 1.419 1.00
82_D 177_F 1.416 1.00
55_A 207_V 1.412 1.00
121_G 243_V 1.398 0.99
114_P 254_L 1.388 0.99
152_V 166_F 1.387 0.99
71_Y 227_S 1.383 0.99
143_P 147_I 1.352 0.99
90_T 193_S 1.347 0.99
89_M 146_L 1.338 0.99
247_A 251_A 1.331 0.99
244_I 248_V 1.321 0.99
89_M 149_G 1.31 0.99
88_A 92_V 1.301 0.99
27_F 225_M 1.298 0.99
199_L 203_L 1.296 0.99
84_K 88_A 1.294 0.99
94_S 197_G 1.288 0.99
106_A 110_R 1.278 0.99
108_V 112_I 1.271 0.99
68_A 187_K 1.27 0.99
148_A 170_A 1.269 0.99
213_F 217_V 1.26 0.99
70_I 73_I 1.256 0.99
56_T 207_V 1.245 0.98
252_K 255_Y 1.245 0.98
218_G 222_G 1.244 0.98
210_A 214_V 1.228 0.98
80_L 84_K 1.22 0.98
77_V 184_A 1.22 0.98
47_G 53_A 1.216 0.98
95_M 200_L 1.213 0.98
91_F 196_G 1.213 0.98
212_G 216_L 1.189 0.98
167_Y 189_L 1.187 0.98
26_G 30_S 1.187 0.98
89_M 93_G 1.174 0.98
125_L 243_V 1.166 0.97
150_G 154_F 1.161 0.97
240_P 244_I 1.144 0.97
72_F 230_V 1.143 0.97
66_I 70_I 1.138 0.97
111_Q 257_S 1.138 0.97
105_Q 108_V 1.137 0.97
84_K 87_I 1.136 0.97
69_T 188_L 1.136 0.97
77_V 231_L 1.135 0.97
96_S 150_G 1.135 0.97
217_V 221_L 1.13 0.97
234_G 238_I 1.124 0.97
107_D 110_R 1.116 0.96
97_G 154_F 1.097 0.96
179_L 183_T 1.096 0.96
37_L 117_V 1.094 0.96
20_F 24_L 1.093 0.96
208_I 211_T 1.081 0.95
22_A 26_G 1.079 0.95
180_A 230_V 1.074 0.95
118_I 247_A 1.07 0.95
147_I 151_C 1.06 0.95
99_L 102_Q 1.06 0.95
29_D 32_A 1.059 0.95
98_A 196_G 1.059 0.95
222_G 225_M 1.054 0.95
220_F 224_R 1.054 0.95
213_F 216_L 1.052 0.95
75_R 231_L 1.051 0.94
110_R 256_D 1.051 0.94
66_I 191_A 1.049 0.94
98_A 200_L 1.047 0.94
95_M 99_L 1.047 0.94
57_N 61_A 1.045 0.94
72_F 184_A 1.043 0.94
29_D 36_G 1.041 0.94
100_L 103_Y 1.037 0.94
50_P 113_L 1.037 0.94
29_D 190_N 1.03 0.94
67_S 223_A 1.027 0.94
68_A 223_A 1.024 0.93
13_L 17_V 1.022 0.93
200_L 204_G 1.017 0.93
111_Q 254_L 1.015 0.93
129_K 132_E 1.009 0.93
161_P 165_S 1.006 0.93
237_L 241_M 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
2f2bA10.706315.40.945Contact Map0.4
3o7qA10.895914.80.945Contact Map0.361
2nwlA30.293710.50.948Contact Map0.459
2gfpA20.88859.30.95Contact Map0.189
3llqA20.74357.90.951Contact Map0.315
3l1lA10.4874.20.957Contact Map0.353
1iflA10.19333.40.959Contact Map0.119
2a65A10.494430.96Contact Map0.501
4i0uA100.26392.70.961Contact Map0.557
4ev6A50.26392.50.962Contact Map0.356

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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