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OPENSEQ.org
YECA - Uncharacterized protein YecA
UniProt: P0AD05 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11139
Length: 221 (219)
Sequences: 232
Seq/Len: 1.06
YECA
Paralog alert: 0.07 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
42_S 121_Y 2.599 1.00
13_W 74_R 2.557 0.99
52_W 83_M 1.893 0.94
49_P 80_F 1.865 0.93
39_A 124_G 1.826 0.92
122_M 125_V 1.798 0.92
38_T 97_F 1.793 0.92
6_L 10_E 1.68 0.88
51_Q 128_S 1.678 0.88
207_C 211_S 1.6 0.84
49_P 53_L 1.592 0.84
210_G 218_C 1.564 0.82
211_S 218_C 1.545 0.81
203_R 216_K 1.539 0.81
203_R 214_K 1.526 0.80
204_N 216_K 1.491 0.78
214_K 218_C 1.488 0.77
118_C 121_Y 1.481 0.77
204_N 214_K 1.48 0.77
121_Y 175_A 1.474 0.77
68_S 124_G 1.463 0.76
207_C 218_C 1.451 0.75
209_C 218_C 1.451 0.75
17_I 75_F 1.445 0.75
41_L 53_L 1.423 0.73
34_D 82_H 1.421 0.73
203_R 211_S 1.413 0.72
39_A 118_C 1.41 0.72
207_C 210_G 1.348 0.67
203_R 207_C 1.335 0.66
203_R 209_C 1.335 0.66
204_N 211_S 1.33 0.65
210_G 214_K 1.309 0.64
10_E 81_Q 1.301 0.63
32_E 121_Y 1.268 0.60
211_S 216_K 1.267 0.60
211_S 214_K 1.26 0.59
190_A 198_E 1.259 0.59
33_L 120_G 1.258 0.59
212_G 218_C 1.256 0.59
8_E 14_L 1.25 0.58
203_R 218_C 1.25 0.58
204_N 207_C 1.24 0.57
204_N 209_C 1.24 0.57
202_G 205_D 1.238 0.57
17_I 20_K 1.234 0.57
31_A 34_D 1.225 0.56
51_Q 175_A 1.219 0.55
207_C 212_G 1.219 0.55
209_C 212_G 1.219 0.55
6_L 81_Q 1.219 0.55
37_L 74_R 1.217 0.55
203_R 206_P 1.216 0.55
210_G 216_K 1.214 0.55
196_K 201_P 1.214 0.55
212_G 216_K 1.206 0.54
210_G 215_F 1.205 0.54
122_M 146_L 1.194 0.53
73_T 77_N 1.192 0.53
207_C 216_K 1.174 0.51
209_C 216_K 1.174 0.51
50_E 72_M 1.174 0.51
35_G 86_T 1.17 0.51
26_A 37_L 1.169 0.51
207_C 214_K 1.167 0.51
209_C 214_K 1.167 0.51
204_N 218_C 1.162 0.50
51_Q 171_I 1.16 0.50
50_E 80_F 1.16 0.50
43_S 163_A 1.144 0.48
200_K 206_P 1.144 0.48
68_S 109_S 1.141 0.48
50_E 84_A 1.125 0.47
215_F 218_C 1.124 0.47
72_M 80_F 1.114 0.46
203_R 210_G 1.105 0.45
205_D 213_K 1.099 0.44
53_L 56_V 1.088 0.43
39_A 182_W 1.088 0.43
208_P 212_G 1.083 0.43
208_P 216_K 1.083 0.43
37_L 40_V 1.081 0.43
33_L 144_I 1.081 0.43
196_K 200_K 1.072 0.42
204_N 210_G 1.068 0.41
57_W 171_I 1.067 0.41
33_L 57_W 1.067 0.41
136_S 181_Y 1.063 0.41
77_N 84_A 1.058 0.40
9_S 68_S 1.058 0.40
203_R 212_G 1.058 0.40
58_G 78_L 1.056 0.40
202_G 208_P 1.054 0.40
211_S 215_F 1.054 0.40
208_P 214_K 1.052 0.40
43_S 181_Y 1.052 0.40
103_L 110_E 1.05 0.40
37_L 127_L 1.045 0.39
118_C 122_M 1.045 0.39
20_K 23_T 1.044 0.39
104_R 107_D 1.044 0.39
10_E 13_W 1.043 0.39
165_E 201_P 1.039 0.39
87_A 90_L 1.039 0.39
55_A 58_G 1.037 0.39
43_S 57_W 1.034 0.38
56_V 181_Y 1.031 0.38
203_R 213_K 1.028 0.38
26_A 144_I 1.018 0.37
168_V 178_L 1.015 0.37
114_V 124_G 1.011 0.36
207_C 215_F 1.009 0.36
209_C 215_F 1.009 0.36
17_I 21_Y 1.007 0.36
36_L 54_V 1 0.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4gytA20.82811000.6Contact Map0.312
1izmA10.79191000.623Contact Map0.393
1tf5A10.873399.70.748Contact Map0.172
2i9wA10.714999.40.803Contact Map0.226
2ipcA40.868899.10.824Contact Map0.131
1ozbI20.099598.90.837Contact Map0.23
4i6pA20.144820.20.959Contact Map0.103
3oeqA10.411811.60.963Contact Map0.076
4jpdA10.42086.40.967Contact Map0.102
2ktgA10.37150.969Contact Map0.286
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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