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OPENSEQ.org
MPAA - Protein MpaA
UniProt: P0ACV6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13906
Length: 242 (218)
Sequences: 1556
Seq/Len: 7.14
MPAA
Paralog alert: 0.14 [within 20: 0.06] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
46_A 59_L 4.378 1.00
133_G 142_C 2.926 1.00
19_H 28_P 2.871 1.00
47_G 56_V 2.771 1.00
29_L 140_A 2.744 1.00
22_R 28_P 2.55 1.00
95_V 135_E 2.5 1.00
136_P 140_A 2.471 1.00
74_H 144_L 2.456 1.00
102_P 133_G 2.403 1.00
63_L 75_V 2.34 1.00
59_L 156_F 2.319 1.00
45_L 155_S 2.299 1.00
48_T 101_F 2.271 1.00
27_A 85_Q 2.23 1.00
29_L 76_V 2.074 1.00
19_H 22_R 1.978 1.00
157_H 210_E 1.91 1.00
31_W 76_V 1.886 1.00
16_G 33_P 1.851 1.00
196_G 208_T 1.844 1.00
175_L 179_F 1.789 1.00
100_N 135_E 1.727 1.00
36_A 39_R 1.681 1.00
22_R 26_G 1.671 1.00
33_P 72_R 1.656 1.00
189_Y 210_E 1.652 1.00
133_G 138_T 1.64 1.00
32_F 63_L 1.634 1.00
98_N 210_E 1.605 1.00
46_A 55_S 1.597 1.00
181_L 222_K 1.552 1.00
172_G 183_L 1.544 1.00
199_C 204_L 1.534 0.99
105_N 108_E 1.529 0.99
18_E 31_W 1.503 0.99
100_N 134_S 1.496 0.99
145_I 202_L 1.476 0.99
41_S 74_H 1.469 0.99
41_S 72_R 1.468 0.99
48_T 155_S 1.439 0.99
139_Q 143_Q 1.424 0.99
47_G 84_C 1.409 0.99
23_S 136_P 1.368 0.99
169_S 173_E 1.358 0.98
142_C 146_H 1.349 0.98
153_V 195_F 1.338 0.98
88_L 116_N 1.329 0.98
54_S 158_D 1.312 0.98
145_I 199_C 1.307 0.98
31_W 74_H 1.305 0.98
143_Q 146_H 1.298 0.98
107_K 128_T 1.298 0.98
33_P 74_H 1.293 0.98
17_T 30_I 1.289 0.98
35_P 39_R 1.289 0.98
53_N 87_G 1.28 0.97
54_S 219_A 1.277 0.97
80_N 83_G 1.272 0.97
179_F 224_L 1.27 0.97
199_C 206_C 1.267 0.97
191_T 194_S 1.257 0.97
102_P 142_C 1.243 0.97
20_Y 140_A 1.236 0.97
53_N 84_C 1.236 0.97
56_V 84_C 1.233 0.97
116_N 121_E 1.228 0.97
168_H 171_L 1.222 0.96
88_L 115_W 1.21 0.96
225_F 232_R 1.189 0.96
191_T 196_G 1.183 0.95
101_F 138_T 1.169 0.95
212_P 222_K 1.165 0.95
194_S 198_W 1.161 0.95
20_Y 76_V 1.143 0.94
50_G 87_G 1.131 0.94
144_L 148_I 1.128 0.94
20_Y 31_W 1.121 0.93
48_T 97_L 1.121 0.93
99_R 189_Y 1.103 0.93
25_L 86_L 1.101 0.93
49_H 52_E 1.099 0.93
21_G 140_A 1.099 0.93
116_N 123_D 1.093 0.92
164_E 185_T 1.092 0.92
20_Y 28_P 1.085 0.92
19_H 30_I 1.076 0.92
43_L 76_V 1.074 0.91
24_L 136_P 1.066 0.91
89_R 99_R 1.061 0.91
43_L 153_V 1.057 0.91
23_S 29_L 1.057 0.91
47_G 78_C 1.051 0.90
43_L 141_L 1.046 0.90
41_S 144_L 1.041 0.90
35_P 72_R 1.039 0.90
49_H 157_H 1.033 0.89
153_V 199_C 1.025 0.89
98_N 189_Y 1.024 0.89
156_F 209_A 1.021 0.88
89_R 98_N 1.02 0.88
42_G 71_R 1.016 0.88
139_Q 142_C 1.014 0.88
133_G 139_Q 1.001 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2boaA20.96691000.311Contact Map0.831
1pcaA101000.315Contact Map
1ayeA10.96691000.315Contact Map0.799
1kwmA20.96691000.315Contact Map0.808
3dgvA30.96691000.318Contact Map0.828
1jqgA10.96281000.327Contact Map0.75
4f8zA10.96691000.332Contact Map0.763
1z5rA30.96281000.344Contact Map0.817
1dtdA10.96691000.347Contact Map0.769
2bo9A20.96281000.349Contact Map0.849
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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