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OPENSEQ.org

YTFH - Uncharacterized HTH-type transcriptional regulator YtfH
UniProt: P0ACN2 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12508
Length: 126 (110)
Sequences: 3859
Seq/Len: 35.08

YTFH
Paralog alert: 0.44 [within 20: 0.08] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
83_V 87_H 3.07 1.00
77_N 91_S 2.848 1.00
61_K 65_Q 2.81 1.00
79_I 91_S 2.65 1.00
98_Q 112_L 2.615 1.00
52_R 60_E 2.524 1.00
77_N 93_T 2.385 1.00
42_R 100_S 2.167 1.00
81_Y 89_E 2.112 1.00
41_L 76_L 2.094 1.00
40_A 54_K 2.048 1.00
37_I 66_S 2.023 1.00
81_Y 87_H 2.004 1.00
45_T 91_S 1.812 1.00
64_A 68_Q 1.74 1.00
101_E 105_A 1.694 1.00
25_V 106_L 1.686 1.00
95_L 113_N 1.616 1.00
62_M 65_Q 1.609 1.00
94_P 97_E 1.595 1.00
41_L 51_L 1.577 1.00
102_K 105_A 1.576 1.00
92_L 96_G 1.502 1.00
98_Q 109_W 1.469 1.00
34_G 66_S 1.435 1.00
78_R 88_V 1.426 1.00
34_G 69_A 1.414 1.00
68_Q 71_E 1.402 0.99
97_E 100_S 1.402 0.99
46_H 54_K 1.348 0.99
47_R 89_E 1.342 0.99
95_L 98_Q 1.339 0.99
25_V 110_I 1.314 0.99
79_I 89_E 1.313 0.99
107_A 111_E 1.313 0.99
81_Y 86_P 1.261 0.99
38_L 92_L 1.23 0.98
75_F 99_V 1.229 0.98
48_F 64_A 1.226 0.98
31_S 69_A 1.214 0.98
31_S 66_S 1.205 0.98
60_E 64_A 1.2 0.98
28_H 73_D 1.161 0.97
98_Q 113_N 1.159 0.97
82_P 85_P 1.159 0.97
80_A 85_P 1.155 0.97
105_A 108_D 1.117 0.96
75_F 96_G 1.106 0.96
71_E 76_L 1.096 0.96
81_Y 85_P 1.093 0.96
31_S 34_G 1.059 0.95
33_W 58_V 1.036 0.94
58_V 63_L 1.027 0.94
49_S 53_R 1.026 0.94
28_H 75_F 1.016 0.93
45_T 89_E 1.016 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4gcvA120.920699.90.404Contact Map0.758
1yyvA2199.70.489Contact Map0.706
4a5nA40.952499.70.501Contact Map0.768
4hqeA20.88199.70.511Contact Map0.823
2fswA20.849299.70.521Contact Map0.892
2hztA40.849299.70.527Contact Map0.842
1z7uA20.888999.70.531Contact Map0.755
2f2eA20.920699.60.536Contact Map0.75
4hw0A30.801699.60.558Contact Map0.762
3df8A10.849299.50.581Contact Map0.622

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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