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OPENSEQ.org
HEMY - Protein HemY
UniProt: P0ACB7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10434
Length: 398 (391)
Sequences: 493
Seq/Len: 1.26
HEMY
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
318_R 346_E 2.806 1.00
263_V 289_G 2.12 0.98
202_A 205_S 2.101 0.98
28_V 44_L 2.091 0.98
30_I 37_I 2.083 0.98
133_D 136_R 1.78 0.93
2_L 10_L 1.748 0.93
50_L 58_I 1.701 0.91
376_K 379_E 1.674 0.90
88_T 120_N 1.663 0.90
350_A 354_A 1.66 0.90
48_L 57_A 1.625 0.89
287_I 302_I 1.609 0.88
126_E 161_R 1.597 0.87
286_I 298_L 1.583 0.87
354_A 367_L 1.572 0.86
343_E 350_A 1.57 0.86
57_A 62_L 1.567 0.86
158_T 162_L 1.564 0.86
206_L 231_A 1.541 0.85
58_I 62_L 1.533 0.84
224_R 342_G 1.53 0.84
159_R 163_Q 1.511 0.83
56_F 60_W 1.509 0.83
209_I 352_R 1.505 0.83
302_I 317_L 1.503 0.83
168_E 171_A 1.501 0.83
104_E 128_A 1.5 0.82
331_W 350_A 1.479 0.81
159_R 162_L 1.453 0.80
220_D 223_H 1.452 0.80
190_L 213_M 1.414 0.77
10_L 65_I 1.405 0.76
11_L 14_G 1.405 0.76
69_G 88_T 1.391 0.75
257_R 261_H 1.388 0.75
62_L 222_E 1.388 0.75
104_E 140_H 1.387 0.75
29_L 36_N 1.377 0.74
163_Q 175_G 1.376 0.74
30_I 54_V 1.373 0.74
17_V 380_A 1.366 0.73
343_E 346_E 1.364 0.73
30_I 46_I 1.349 0.72
146_E 356_K 1.349 0.72
215_K 298_L 1.338 0.71
331_W 353_A 1.333 0.71
50_L 54_V 1.33 0.71
86_K 115_E 1.316 0.69
104_E 131_R 1.309 0.69
324_V 327_R 1.305 0.69
107_M 298_L 1.304 0.68
332_S 363_D 1.285 0.67
80_K 110_N 1.267 0.65
296_D 327_R 1.266 0.65
42_T 76_F 1.262 0.65
277_D 355_L 1.258 0.64
95_L 127_A 1.251 0.64
122_L 215_K 1.249 0.64
35_Y 92_L 1.249 0.64
4_V 136_R 1.239 0.63
265_L 375_H 1.236 0.62
328_P 357_Q 1.234 0.62
282_A 325_G 1.227 0.62
30_I 44_L 1.226 0.61
101_Q 327_R 1.223 0.61
352_R 356_K 1.222 0.61
178_K 388_L 1.22 0.61
56_F 59_E 1.218 0.61
302_I 313_L 1.21 0.60
348_S 352_R 1.206 0.60
52_M 338_L 1.204 0.59
339_M 370_A 1.204 0.59
312_Q 379_E 1.204 0.59
16_V 60_W 1.198 0.59
95_L 179_L 1.198 0.59
171_A 175_G 1.197 0.59
294_Y 320_Q 1.197 0.59
217_H 282_A 1.196 0.59
177_D 210_I 1.193 0.58
10_L 13_A 1.184 0.57
336_Q 366_W 1.183 0.57
72_T 105_K 1.178 0.57
331_W 354_A 1.176 0.57
372_D 385_R 1.172 0.56
134_E 138_N 1.171 0.56
330_L 354_A 1.17 0.56
29_L 38_E 1.161 0.55
182_V 359_P 1.156 0.55
91_A 100_Y 1.155 0.55
62_L 238_Q 1.153 0.54
170_H 174_H 1.144 0.54
97_E 354_A 1.143 0.53
313_L 387_G 1.139 0.53
55_L 85_R 1.137 0.53
50_L 127_A 1.136 0.53
248_L 252_W 1.135 0.53
32_T 49_I 1.134 0.53
8_F 12_I 1.134 0.53
366_W 369_D 1.134 0.53
303_P 317_L 1.134 0.53
109_K 115_E 1.13 0.52
91_A 107_M 1.13 0.52
30_I 315_K 1.126 0.52
25_Q 265_L 1.125 0.52
2_L 6_L 1.125 0.52
158_T 381_A 1.124 0.52
141_L 144_A 1.124 0.52
16_V 19_P 1.123 0.51
39_T 43_G 1.122 0.51
210_I 224_R 1.121 0.51
104_E 136_R 1.121 0.51
44_L 385_R 1.12 0.51
250_N 386_D 1.119 0.51
97_E 144_A 1.118 0.51
45_A 339_M 1.118 0.51
50_L 53_V 1.117 0.51
59_E 338_L 1.116 0.51
170_H 208_D 1.113 0.50
364_Y 383_M 1.113 0.50
27_Y 38_E 1.109 0.50
95_L 215_K 1.107 0.50
283_Q 286_I 1.106 0.50
18_G 28_V 1.106 0.50
62_L 65_I 1.101 0.49
201_G 328_P 1.1 0.49
231_A 265_L 1.098 0.49
37_I 260_R 1.096 0.49
65_I 174_H 1.092 0.48
336_Q 362_Y 1.091 0.48
273_L 336_Q 1.091 0.48
302_I 320_Q 1.088 0.48
193_A 197_Y 1.088 0.48
224_R 344_W 1.087 0.48
28_V 40_S 1.087 0.48
51_A 66_F 1.087 0.48
295_D 329_L 1.083 0.48
55_L 58_I 1.082 0.47
91_A 341_H 1.082 0.47
123_L 154_P 1.079 0.47
338_L 345_Q 1.079 0.47
176_V 236_M 1.078 0.47
339_M 367_L 1.077 0.47
173_R 177_D 1.077 0.47
137_A 140_H 1.077 0.47
52_M 56_F 1.076 0.47
317_L 350_A 1.076 0.47
244_G 380_A 1.076 0.47
46_I 293_Q 1.074 0.47
80_K 151_D 1.073 0.47
100_Y 269_M 1.07 0.46
136_R 139_Q 1.069 0.46
223_H 269_M 1.068 0.46
33_D 355_L 1.067 0.46
120_N 144_A 1.067 0.46
321_I 350_A 1.066 0.46
96_A 161_R 1.064 0.46
146_E 277_D 1.063 0.46
46_I 277_D 1.062 0.45
28_V 227_L 1.061 0.45
314_E 341_H 1.056 0.45
37_I 286_I 1.054 0.45
63_R 187_P 1.053 0.45
92_L 210_I 1.052 0.44
365_A 372_D 1.051 0.44
233_I 268_A 1.05 0.44
87_Q 96_A 1.048 0.44
97_E 186_H 1.046 0.44
194_E 206_L 1.045 0.44
155_V 189_V 1.041 0.43
278_D 281_T 1.039 0.43
49_I 171_A 1.037 0.43
5_L 21_I 1.037 0.43
87_Q 110_N 1.037 0.43
118_V 155_V 1.036 0.43
102_Q 106_L 1.036 0.43
51_A 122_L 1.036 0.43
5_L 40_S 1.034 0.43
181_E 335_G 1.031 0.42
122_L 154_P 1.031 0.42
9_V 250_N 1.029 0.42
53_V 61_L 1.027 0.42
160_V 380_A 1.025 0.42
156_E 179_L 1.023 0.42
55_L 238_Q 1.02 0.41
272_H 370_A 1.02 0.41
32_T 302_I 1.02 0.41
198_I 230_Q 1.015 0.41
256_S 337_S 1.013 0.41
65_I 199_R 1.011 0.41
342_G 345_Q 1.01 0.40
118_V 144_A 1.01 0.40
210_I 228_E 1.009 0.40
69_G 287_I 1.009 0.40
80_K 94_K 1.007 0.40
10_L 222_E 1.007 0.40
124_A 140_H 1.006 0.40
164_L 196_A 1.004 0.40
328_P 354_A 1.003 0.40
64_R 75_W 1.001 0.40
162_L 376_K 1.001 0.40
82_R 326_D 1 0.39
158_T 161_R 1 0.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1w3bA20.763899.80.798Contact Map0.373
2y4tA30.824199.80.804Contact Map0.328
3iegA20.773999.80.807Contact Map0.314
3cv0A10.733799.80.809Contact Map0.381
4kvmA40.886999.80.809Contact Map0.4
3mkrA10.70199.70.814Contact Map0.357
3fp2A10.748799.70.815Contact Map0.458
4jsnB20.751399.70.817Contact Map0.38
3hymB60.786499.70.818Contact Map0.446
2gw1A20.783999.70.821Contact Map0.326
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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