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OPENSEQ.org
DNAB - Replicative DNA helicase
UniProt: P0ACB0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10236
Length: 471 (440)
Sequences: 1930
Seq/Len: 4.39
DNAB
Paralog alert: 0.18 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
327_A 340_I 3.876 1.00
209_T 221_L 3.432 1.00
388_S 391_Q 3.219 1.00
212_D 462_N 3.147 1.00
223_P 376_N 3.023 1.00
399_N 415_I 2.965 1.00
141_E 164_R 2.958 1.00
59_D 130_A 2.945 1.00
255_P 338_G 2.941 1.00
418_I 436_I 2.516 1.00
225_D 267_Q 2.483 1.00
257_L 330_I 2.462 1.00
452_T 463_Y 2.435 1.00
283_K 293_D 2.422 1.00
396_R 435_E 2.389 1.00
240_F 244_L 2.34 1.00
72_M 82_I 2.161 1.00
90_S 93_R 2.161 1.00
248_A 339_L 2.157 1.00
422_E 432_G 2.139 1.00
340_I 377_V 2.131 1.00
255_P 308_R 2.127 1.00
74_R 94_Q 2.113 1.00
130_A 134_E 2.094 1.00
208_N 215_N 2.073 1.00
235_M 424_Y 2.057 1.00
57_A 70_T 2.041 1.00
327_A 375_L 2.013 1.00
311_Y 334_H 2.001 1.00
234_S 443_N 1.99 1.00
226_L 368_L 1.987 1.00
392_R 401_D 1.986 1.00
214_L 416_M 1.98 1.00
217_K 447_G 1.962 1.00
430_L 450_R 1.951 1.00
279_V 297_I 1.936 1.00
180_K 265_S 1.933 1.00
228_I 408_I 1.902 1.00
254_K 338_G 1.873 1.00
41_L 72_M 1.867 1.00
182_I 269_M 1.851 1.00
229_V 380_V 1.847 1.00
228_I 412_A 1.833 1.00
235_M 423_V 1.833 1.00
231_A 418_I 1.83 1.00
365_S 411_D 1.78 1.00
292_E 296_R 1.752 0.99
218_T 414_L 1.749 0.99
323_V 348_M 1.744 0.99
313_D 326_R 1.742 0.99
245_V 341_M 1.738 0.99
414_L 441_Q 1.726 0.99
41_L 48_W 1.717 0.99
365_S 381_A 1.701 0.99
145_A 160_L 1.692 0.99
221_L 339_L 1.689 0.99
441_Q 445_P 1.674 0.99
69_F 73_A 1.665 0.99
54_R 123_A 1.664 0.99
320_P 367_S 1.662 0.99
90_S 94_Q 1.648 0.99
139_A 143_A 1.627 0.99
71_E 90_S 1.622 0.99
417_F 439_G 1.62 0.99
78_S 90_S 1.619 0.99
42_M 87_L 1.608 0.99
386_N 423_V 1.59 0.99
421_D 425_H 1.575 0.99
48_W 73_A 1.574 0.99
277_S 457_W 1.57 0.99
74_R 90_S 1.547 0.98
97_L 101_G 1.541 0.98
454_N 461_D 1.535 0.98
357_R 404_E 1.531 0.98
357_R 360_E 1.53 0.98
114_P 122_Y 1.524 0.98
188_A 266_E 1.523 0.98
437_I 448_T 1.522 0.98
88_A 106_L 1.522 0.98
341_M 380_V 1.52 0.98
240_F 436_I 1.514 0.98
224_S 264_P 1.509 0.98
58_D 66_R 1.507 0.98
433_I 450_R 1.5 0.98
389_L 423_V 1.5 0.98
239_T 458_S 1.481 0.98
249_A 256_V 1.479 0.98
280_D 283_K 1.466 0.98
207_V 248_A 1.459 0.98
210_G 215_N 1.457 0.97
63_R 66_R 1.427 0.97
164_R 167_K 1.422 0.97
244_L 248_A 1.419 0.97
38_L 65_H 1.408 0.97
57_A 73_A 1.406 0.97
433_I 463_Y 1.397 0.97
28_P 136_I 1.393 0.96
225_D 443_N 1.39 0.96
229_V 241_A 1.386 0.96
318_L 323_V 1.386 0.96
222_Q 225_D 1.385 0.96
89_E 93_R 1.385 0.96
273_L 297_I 1.384 0.96
26_V 29_H 1.379 0.96
257_L 340_I 1.373 0.96
323_V 342_I 1.373 0.96
229_V 240_F 1.368 0.96
345_L 408_I 1.367 0.96
386_N 389_L 1.361 0.96
54_R 124_D 1.353 0.96
339_L 380_V 1.349 0.96
278_R 457_W 1.348 0.95
217_K 438_I 1.343 0.95
246_E 276_L 1.338 0.95
239_T 271_R 1.337 0.95
234_S 446_I 1.335 0.95
213_D 216_K 1.333 0.95
396_R 437_I 1.323 0.95
242_M 272_S 1.308 0.94
136_I 146_G 1.305 0.94
240_F 418_I 1.298 0.94
331_A 337_I 1.296 0.94
213_D 462_N 1.293 0.94
193_I 297_I 1.29 0.94
132_V 157_L 1.286 0.94
185_V 265_S 1.285 0.94
211_Y 451_L 1.277 0.93
120_S 124_D 1.276 0.93
406_G 409_E 1.271 0.93
47_R 119_I 1.27 0.93
163_S 167_K 1.266 0.93
234_S 441_Q 1.261 0.93
179_P 257_L 1.259 0.93
231_A 235_M 1.256 0.93
138_V 165_V 1.252 0.93
250_M 307_K 1.247 0.92
35_Q 105_Y 1.231 0.92
194_E 198_Q 1.225 0.92
41_L 51_V 1.223 0.91
67_H 96_Q 1.222 0.91
129_R 132_V 1.216 0.91
33_A 126_V 1.214 0.91
403_R 410_Q 1.214 0.91
227_I 380_V 1.206 0.91
418_I 434_A 1.205 0.91
246_E 275_S 1.204 0.91
285_R 441_Q 1.202 0.90
35_Q 112_N 1.202 0.90
249_A 310_I 1.201 0.90
435_E 448_T 1.2 0.90
71_E 87_L 1.193 0.90
59_D 127_R 1.192 0.90
179_P 330_I 1.184 0.90
37_V 126_V 1.181 0.89
96_Q 99_S 1.177 0.89
28_P 61_Y 1.174 0.89
311_Y 330_I 1.17 0.89
208_N 252_Q 1.169 0.89
189_T 193_I 1.166 0.89
31_I 62_T 1.163 0.88
235_M 434_A 1.158 0.88
205_T 222_Q 1.155 0.88
137_S 141_E 1.154 0.88
315_S 323_V 1.154 0.88
390_E 395_K 1.153 0.88
362_A 407_S 1.151 0.88
40_G 119_I 1.151 0.88
327_A 379_V 1.137 0.87
192_R 196_L 1.136 0.87
232_R 390_E 1.132 0.87
392_R 398_V 1.131 0.87
441_Q 444_G 1.126 0.86
37_V 55_V 1.117 0.86
261_L 318_L 1.116 0.86
245_V 258_I 1.112 0.85
119_I 123_A 1.108 0.85
153_T 156_D 1.103 0.85
68_I 105_Y 1.102 0.85
134_E 137_S 1.101 0.84
65_H 105_Y 1.094 0.84
65_H 68_I 1.092 0.84
395_K 424_Y 1.09 0.84
371_L 375_L 1.087 0.83
257_L 327_A 1.085 0.83
181_N 184_D 1.08 0.83
258_I 310_I 1.079 0.83
278_R 461_D 1.075 0.82
434_A 460_F 1.075 0.82
212_D 216_K 1.073 0.82
38_L 109_L 1.071 0.82
416_M 436_I 1.07 0.82
358_T 362_A 1.067 0.82
131_V 158_L 1.059 0.81
224_S 376_N 1.057 0.81
277_S 300_T 1.047 0.80
255_P 335_G 1.046 0.80
88_A 97_L 1.042 0.80
232_R 410_Q 1.042 0.80
276_L 303_I 1.038 0.79
139_A 146_G 1.037 0.79
222_Q 443_N 1.034 0.79
335_G 338_G 1.034 0.79
225_D 441_Q 1.03 0.79
419_Y 424_Y 1.027 0.78
180_K 188_A 1.027 0.78
160_L 163_S 1.025 0.78
230_A 405_S 1.02 0.78
83_D 118_N 1.018 0.77
239_T 242_M 1.016 0.77
386_N 415_I 1.013 0.77
280_D 456_Q 1.012 0.77
325_S 329_R 1.012 0.77
189_T 270_M 1.009 0.77
241_A 341_M 1.006 0.76
423_V 446_I 1.004 0.76
233_P 409_E 1.004 0.76
302_G 306_E 1.001 0.76
32_E 35_Q 1 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2q6tA40.93421000.279Contact Map0.809
3bgwA60.93211000.289Contact Map0.776
2r6aA20.94481000.313Contact Map0.802
4a1fA20.61571000.562Contact Map0.707
3bh0A10.65821000.573Contact Map0.676
1cr0A10.57961000.647Contact Map0.653
1q57A70.90451000.661Contact Map0.568
3io5A20.47131000.705Contact Map0.404
3cmwA20.51171000.724Contact Map0.612
1nlfA30.53931000.737Contact Map0.495
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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