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OPENSEQ.org
TTDB - L(+)-tartrate dehydratase subunit beta
UniProt: P0AC35 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11169
Length: 201 (187)
Sequences: 873
Seq/Len: 4.67
TTDB
Paralog alert: 0.35 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
136_E 158_K 5.453 1.00
107_P 111_E 3.905 1.00
39_R 145_E 3.752 1.00
139_E 154_V 3.672 1.00
15_Q 117_K 3.198 1.00
11_A 97_K 3.007 1.00
137_E 156_R 2.944 1.00
49_Y 53_G 2.909 1.00
42_E 89_E 2.806 1.00
28_T 154_V 2.309 1.00
92_E 116_F 2.266 1.00
59_A 75_V 2.188 1.00
110_E 173_N 2.186 1.00
40_L 47_I 2.147 1.00
88_R 116_F 2.109 1.00
13_D 16_D 2.093 1.00
88_R 115_K 2.011 1.00
55_A 98_L 1.944 1.00
75_V 135_V 1.909 1.00
92_E 115_K 1.906 1.00
122_I 166_S 1.896 1.00
98_L 121_V 1.871 1.00
18_R 170_H 1.778 1.00
111_E 115_K 1.774 1.00
110_E 167_I 1.763 1.00
88_R 92_E 1.755 1.00
31_T 155_C 1.752 1.00
136_E 156_R 1.727 1.00
172_N 177_E 1.655 0.99
87_E 91_I 1.626 0.99
17_I 165_V 1.614 0.99
40_L 152_L 1.614 0.99
51_L 90_F 1.545 0.99
72_M 155_C 1.542 0.99
4_I 159_E 1.54 0.99
167_I 173_N 1.529 0.99
57_F 75_V 1.528 0.99
25_L 163_L 1.516 0.98
80_S 101_G 1.437 0.98
32_C 56_I 1.396 0.97
39_R 144_T 1.39 0.97
10_K 13_D 1.378 0.97
7_T 25_L 1.374 0.97
160_F 163_L 1.318 0.95
89_E 92_E 1.299 0.95
176_A 180_K 1.289 0.95
28_T 156_R 1.282 0.94
26_T 158_K 1.273 0.94
58_H 87_E 1.271 0.94
180_K 183_A 1.208 0.92
18_R 172_N 1.197 0.91
91_I 118_A 1.194 0.91
11_A 52_N 1.183 0.90
98_L 119_L 1.177 0.90
46_P 52_N 1.163 0.89
49_Y 152_L 1.163 0.89
88_R 112_G 1.15 0.89
9_I 55_A 1.142 0.88
111_E 114_Q 1.137 0.88
14_L 119_L 1.132 0.88
75_V 138_I 1.113 0.87
29_L 45_R 1.106 0.86
66_N 69_K 1.105 0.86
7_T 10_K 1.104 0.86
91_I 99_V 1.1 0.86
43_L 46_P 1.098 0.86
6_T 156_R 1.097 0.85
112_G 116_F 1.095 0.85
57_F 127_C 1.082 0.84
9_I 14_L 1.081 0.84
53_G 97_K 1.074 0.84
49_Y 141_V 1.074 0.84
40_L 51_L 1.064 0.83
107_P 176_A 1.055 0.82
29_L 100_V 1.052 0.82
3_K 16_D 1.045 0.81
30_V 141_V 1.042 0.81
173_N 176_A 1.038 0.81
36_C 152_L 1.037 0.81
130_L 134_Q 1.03 0.80
89_E 93_Q 1.028 0.80
135_V 160_F 1.016 0.79
117_K 169_T 1.008 0.78
138_I 153_W 1 0.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2isbA10.87061000.11Contact Map0.582
2vl6A30.288638.90.957Contact Map0.674
2kijA10.4527160.965Contact Map0.053
1y96B20.144315.10.965Contact Map0.163
1k0hA10.263714.50.965Contact Map0.526
2v31A10.213913.90.966Contact Map0
2lzjA10.213913.90.966Contact Map0.293
1tp9A40.691512.20.966Contact Map0.253
2vb2X10.189112.10.966Contact Map0
2f9sA20.6766120.966Contact Map0.326
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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