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OPENSEQ.org
FTSX - Cell division protein FtsX
UniProt: P0AC30 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10345
Length: 352 (302)
Sequences: 980
Seq/Len: 3.25
FTSX
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
128_V 132_Q 3.51 1.00
81_I 283_G 2.987 1.00
128_V 174_A 2.886 1.00
121_D 125_A 2.716 1.00
127_V 198_I 2.613 1.00
259_K 265_D 2.613 1.00
120_D 123_A 2.59 1.00
131_L 137_V 2.37 1.00
110_Q 177_I 2.286 1.00
276_G 334_G 2.158 1.00
63_A 274_Y 2.056 1.00
140_V 174_A 2.044 1.00
119_L 200_G 1.975 1.00
145_R 172_A 1.94 1.00
141_N 147_D 1.927 1.00
147_D 151_E 1.804 0.99
131_L 195_I 1.793 0.99
185_T 215_A 1.785 0.99
232_M 337_A 1.753 0.99
176_V 201_I 1.751 0.99
152_F 170_L 1.646 0.98
89_S 283_G 1.612 0.98
178_P 191_L 1.607 0.98
192_R 204_V 1.588 0.98
281_F 331_S 1.543 0.97
134_E 194_R 1.522 0.97
255_I 342_T 1.473 0.96
115_L 127_V 1.448 0.95
251_R 257_V 1.444 0.95
261_I 283_G 1.44 0.95
67_L 74_T 1.428 0.95
112_T 245_R 1.418 0.94
258_Q 263_A 1.417 0.94
184_G 187_S 1.405 0.94
114_Y 203_E 1.397 0.94
249_F 252_R 1.373 0.93
269_L 346_L 1.36 0.93
137_V 176_V 1.355 0.93
82_A 290_L 1.347 0.92
276_G 338_A 1.346 0.92
113_V 201_I 1.327 0.91
89_S 330_C 1.31 0.91
150_G 154_N 1.307 0.91
113_V 176_V 1.306 0.91
334_G 337_A 1.3 0.90
97_N 238_L 1.3 0.90
147_D 201_I 1.298 0.90
143_L 148_A 1.295 0.90
263_A 268_I 1.294 0.90
126_G 130_Q 1.288 0.90
127_V 200_G 1.286 0.90
289_I 293_I 1.279 0.89
298_L 333_I 1.278 0.89
87_L 305_V 1.275 0.89
78_V 286_L 1.269 0.89
277_A 331_S 1.263 0.89
196_T 252_R 1.26 0.88
153_R 163_D 1.252 0.88
89_S 291_S 1.251 0.88
284_A 288_L 1.247 0.88
324_L 328_L 1.241 0.87
138_E 179_K 1.237 0.87
63_A 278_L 1.215 0.86
116_Q 202_D 1.213 0.86
228_I 328_L 1.212 0.86
69_S 140_V 1.21 0.86
116_Q 200_G 1.203 0.85
119_L 124_A 1.2 0.85
110_Q 175_V 1.196 0.85
232_M 268_I 1.195 0.85
142_Y 172_A 1.189 0.84
338_A 342_T 1.181 0.84
232_M 243_S 1.174 0.83
116_Q 279_L 1.174 0.83
146_E 150_G 1.174 0.83
73_A 76_L 1.169 0.83
258_Q 261_I 1.167 0.83
123_A 126_G 1.165 0.82
131_L 234_A 1.164 0.82
251_R 275_G 1.159 0.82
144_S 172_A 1.156 0.82
97_N 283_G 1.146 0.81
91_C 238_L 1.144 0.81
252_R 272_F 1.141 0.81
148_A 173_V 1.137 0.80
144_S 147_D 1.124 0.79
85_L 255_I 1.12 0.79
288_L 323_C 1.12 0.79
270_R 338_A 1.119 0.79
227_M 230_V 1.114 0.78
254_S 257_V 1.112 0.78
259_K 344_Q 1.11 0.78
77_T 238_L 1.107 0.78
259_K 268_I 1.105 0.78
161_A 164_M 1.104 0.78
187_S 190_T 1.1 0.77
82_A 286_L 1.098 0.77
193_D 196_T 1.096 0.77
211_F 284_A 1.094 0.77
120_D 133_A 1.094 0.77
81_I 110_Q 1.093 0.77
71_P 260_L 1.091 0.76
64_L 291_S 1.084 0.76
143_L 175_V 1.083 0.76
293_I 296_L 1.082 0.76
129_A 132_Q 1.081 0.75
122_D 125_A 1.08 0.75
111_I 174_A 1.079 0.75
285_L 289_I 1.078 0.75
153_R 162_L 1.077 0.75
201_I 204_V 1.075 0.75
224_V 343_V 1.069 0.74
304_E 328_L 1.065 0.74
294_L 298_L 1.064 0.74
243_S 342_T 1.057 0.73
113_V 195_I 1.056 0.73
124_A 128_V 1.056 0.73
248_I 255_I 1.055 0.73
111_I 244_V 1.053 0.73
97_N 295_V 1.048 0.72
85_L 175_V 1.048 0.72
61_H 64_L 1.043 0.72
148_A 170_L 1.041 0.71
284_A 304_E 1.041 0.71
60_F 64_L 1.037 0.71
192_R 196_T 1.036 0.71
244_V 337_A 1.036 0.71
231_L 245_R 1.032 0.71
113_V 131_L 1.031 0.70
97_N 279_L 1.03 0.70
211_F 235_A 1.03 0.70
283_G 338_A 1.028 0.70
131_L 174_A 1.028 0.70
243_S 246_L 1.027 0.70
115_L 124_A 1.024 0.70
329_V 332_M 1.023 0.70
251_R 254_S 1.014 0.69
100_Q 104_Q 1.012 0.68
273_L 277_A 1.012 0.68
147_D 150_G 1.012 0.68
270_R 274_Y 1.008 0.68
58_Y 80_V 1.004 0.68
237_F 337_A 1.002 0.67
81_I 280_G 1.001 0.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4k0jA60.798375.90.954Contact Map0.235
2zbcA80.23362.30.958Contact Map0.613
2djwA100.258558.50.959Contact Map0.5
3w9iA60.860853.40.961Contact Map0.296
4dx5A30.860848.70.962Contact Map0.283
2cviA20.23346.40.962Contact Map0.633
2pc6A40.423327.80.966Contact Map0.372
2jsxA10.269927.50.967Contact Map0.501
2f1fA20.417625.20.967Contact Map0.381
3ne5A10.619324.40.967Contact Map0.155
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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