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OPENSEQ.org

HCAC - 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit
UniProt: P0ABW0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13458
Length: 106 (102)
Sequences: 4372
Seq/Len: 42.86

HCAC
Paralog alert: 0.55 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: HCAC NIRD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
70_C 73_T 3.52 1.00
5_Y 96_D 3.096 1.00
43_S 69_F 2.725 1.00
9_V 92_V 2.713 1.00
59_T 68_S 2.441 1.00
38_I 85_L 2.102 1.00
40_D 50_S 2.099 1.00
28_L 37_A 2.002 1.00
91_H 98_F 1.95 1.00
9_V 35_F 1.945 1.00
89_P 100_D 1.872 1.00
37_A 90_V 1.86 1.00
39_N 86_T 1.857 1.00
37_A 99_I 1.76 1.00
59_T 77_L 1.755 1.00
26_I 37_A 1.704 1.00
8_P 96_D 1.614 1.00
68_S 78_C 1.586 1.00
40_D 48_S 1.585 1.00
25_V 39_N 1.558 1.00
35_F 90_V 1.522 1.00
36_Y 87_T 1.496 1.00
5_Y 98_F 1.489 1.00
17_A 27_A 1.474 1.00
93_E 98_F 1.438 1.00
39_N 88_Y 1.438 1.00
70_C 77_L 1.42 1.00
61_E 68_S 1.401 0.99
47_A 64_L 1.381 0.99
7_C 12_V 1.375 0.99
35_F 97_I 1.333 0.99
8_P 11_D 1.309 0.99
13_P 16_E 1.282 0.99
29_F 38_I 1.222 0.98
17_A 54_L 1.22 0.98
3_R 91_H 1.203 0.98
17_A 60_V 1.202 0.98
47_A 63_P 1.198 0.98
30_N 35_F 1.187 0.98
92_V 97_I 1.169 0.97
14_E 30_N 1.165 0.97
56_D 61_E 1.165 0.97
35_F 92_V 1.162 0.97
9_V 95_G 1.145 0.97
31_V 36_Y 1.139 0.97
30_N 33_G 1.139 0.97
7_C 11_D 1.127 0.97
7_C 97_I 1.092 0.96
67_A 81_A 1.091 0.96
38_I 87_T 1.064 0.95
45_G 64_L 1.055 0.95
76_A 84_P 1.052 0.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i7fA20.99061000.042Contact Map0.935
1fqtA20.99061000.048Contact Map0.88
2qpzA10.952899.90.057Contact Map0.896
3gceA10.990699.90.058Contact Map0.883
2de6D30.990699.90.066Contact Map0.899
3dqyA10.981199.90.067Contact Map0.937
1vm9A10.971799.90.078Contact Map0.885
3d89A10.990699.90.078Contact Map0.789
2jzaA10.981199.90.083Contact Map0.641
2de6A30.990699.90.088Contact Map0.846

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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