OPENSEQ.org - DPS - ECOLI GREMLIN

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DPS - DNA protection during starvation protein

UniProt:	P0ABT2	Sequence MSTAKLVKSKATNLLYTRNDVSDSEKKATVELLNRQVIQFIDLSLITKQAHWNMRGANFIAVHEMLDGFRTALIDHLDTMAERAVQLGGVALGTTQVINSKTPLKSYPLDIHNVQDHLKELADRYAIVANDVRKAIGEAKDDDTADILTAASRDLDKFLWFIESNIE	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG11415
Length:	167 (153)
Sequences:	1409
Seq/Len:	9.21

DPS
Paralog alert: 0.17 [within 20: 0.01] - ratio of genomes with paralogs

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
113_N	116_D	3.003	1.00
30_V	89_G	2.927	1.00
146_D	150_A	2.832	1.00
46_I	124_R	2.631	1.00
96_Q	100_S	2.347	1.00
146_D	149_T	2.32	1.00
47_T	73_L	2.243	1.00
60_I	64_E	2.23	1.00
50_A	120_E	1.935	1.00
39_Q	103_P	1.92	1.00
67_D	71_T	1.909	1.00
62_V	66_L	1.796	1.00
137_G	145_A	1.759	1.00
136_I	149_T	1.702	1.00
45_L	95_T	1.644	1.00
92_L	101_K	1.613	1.00
126_A	163_E	1.573	1.00
83_R	144_T	1.543	1.00
145_A	149_T	1.539	1.00
69_F	125_Y	1.518	1.00
129_A	152_S	1.489	1.00
60_I	68_G	1.484	1.00
67_D	70_R	1.467	1.00
136_I	145_A	1.453	1.00
42_D	99_N	1.439	0.99
50_A	117_H	1.419	0.99
50_A	107_Y	1.407	0.99
22_S	25_E	1.39	0.99
96_Q	106_S	1.368	0.99
97_V	100_S	1.368	0.99
83_R	141_D	1.362	0.99
34_N	84_A	1.359	0.99
126_A	130_N	1.331	0.99
83_R	156_D	1.326	0.99
34_N	92_L	1.322	0.99
38_I	101_K	1.321	0.99
129_A	156_D	1.318	0.99
51_H	82_E	1.299	0.99
72_A	76_H	1.294	0.99
41_I	98_I	1.291	0.99
65_M	68_G	1.282	0.99
141_D	144_T	1.273	0.98
159_L	163_E	1.266	0.98
87_L	144_T	1.263	0.98
72_A	158_F	1.257	0.98
32_L	135_A	1.246	0.98
60_I	65_M	1.243	0.98
42_D	106_S	1.24	0.98
27_K	31_E	1.235	0.98
107_Y	120_E	1.233	0.98
119_K	166_I	1.232	0.98
142_D	145_A	1.226	0.98
121_L	125_Y	1.214	0.98
79_T	147_I	1.213	0.98
65_M	69_F	1.199	0.98
40_F	80_M	1.194	0.97
51_H	63_H	1.19	0.97
64_E	68_G	1.178	0.97
133_R	156_D	1.166	0.97
75_D	79_T	1.15	0.97
35_R	103_P	1.143	0.96
76_H	151_A	1.13	0.96
125_Y	158_F	1.113	0.96
119_K	123_D	1.112	0.96
142_D	149_T	1.107	0.96
37_V	80_M	1.091	0.95
72_A	154_D	1.091	0.95
143_D	152_S	1.091	0.95
71_T	75_D	1.084	0.95
42_D	95_T	1.081	0.95
122_A	159_L	1.066	0.94
135_A	148_L	1.061	0.94
83_R	87_L	1.059	0.94
59_F	63_H	1.056	0.94
36_Q	135_A	1.056	0.94
49_Q	93_G	1.055	0.94
51_H	59_F	1.049	0.94
59_F	82_E	1.035	0.93
45_L	93_G	1.017	0.92
63_H	82_E	1.016	0.92
90_V	110_D	1.012	0.92
40_F	73_L	1.005	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
3ak8A	12	1	100	0.237	Contact Map	0.756
1zs3A	12	0.9701	100	0.287	Contact Map	0.633
1zujA	4	0.9641	100	0.298	Contact Map	0.623
2c2jA	1	0.994	100	0.331	Contact Map	0.641
2c2uA	1	1	100	0.343	Contact Map	0.608
1tjoA	4	1	100	0.345	Contact Map	0.821
2xgwA	1	1	100	0.354	Contact Map	0.611
2z90A	4	0.9401	100	0.355	Contact Map	0.727
2yw6A	3	0.9281	100	0.357	Contact Map	0.677
4a25A	4	0.9701	100	0.357	Contact Map	0.683

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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