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OPENSEQ.org
HOLE - DNA polymerase III subunit theta
UniProt: P0ABS8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11505
Length: 76 (76)
Sequences: 77
Seq/Len: 1.01
HOLE
Paralog alert: 0.09 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
41_E 53_R 2.706 1.00
38_E 46_E 1.788 0.91
46_E 56_L 1.78 0.90
20_L 24_G 1.613 0.84
39_A 43_E 1.574 0.82
27_F 31_Y 1.555 0.80
5_L 8_L 1.55 0.80
17_N 21_A 1.545 0.80
26_A 58_A 1.478 0.76
38_E 42_R 1.469 0.75
18_V 21_A 1.394 0.69
38_E 43_E 1.344 0.65
68_R 72_E 1.321 0.63
23_A 59_H 1.317 0.63
26_A 63_S 1.315 0.63
23_A 51_W 1.31 0.62
11_T 35_V 1.286 0.60
10_Q 37_A 1.283 0.60
9_D 35_V 1.26 0.58
11_T 16_V 1.224 0.54
15_K 47_H 1.218 0.54
27_F 67_S 1.213 0.53
10_Q 14_D 1.184 0.51
21_A 76_K 1.148 0.47
36_I 75_L 1.146 0.47
6_A 14_D 1.144 0.47
51_W 66_L 1.142 0.47
61_L 64_V 1.14 0.47
3_K 46_E 1.127 0.45
13_M 47_H 1.115 0.44
26_A 32_N 1.114 0.44
21_A 34_P 1.11 0.44
32_N 63_S 1.091 0.42
15_K 40_V 1.091 0.42
58_A 62_A 1.088 0.42
2_L 59_H 1.068 0.40
69_L 72_E 1.067 0.40
23_A 56_L 1.06 0.39
9_D 65_N 1.057 0.39
67_S 76_K 1.049 0.38
28_K 72_E 1.037 0.37
69_L 73_P 1.023 0.36
11_T 76_K 1.015 0.35
1_M 70_P 1.013 0.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1du2A111000.247Contact Map0.053
1se7A1199.90.38Contact Map0.165
1rrzA10.960599.90.448Contact Map0.189
3q23A20.868425.10.922Contact Map0.079
2dt7B10.7368110.933Contact Map0.229
2o8iA10.98688.90.936Contact Map0.129
2dyuA20.90798.90.936Contact Map0.209
2vsqA10.96058.50.937Contact Map0.013
3zf7Q10.82898.40.937Contact Map0.071
1vq8M10.61848.40.937Contact Map0.041
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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