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MHPB - 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase
UniProt: P0ABR9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG20274
Length: 314 (295)
Sequences: 507
Seq/Len: 1.72
MHPB
Paralog alert: 0.24 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
249_R 252_E 3.606 1.00
159_G 163_S 3.245 1.00
90_L 94_C 3.234 1.00
25_D 29_G 3.102 1.00
101_S 160_R 2.931 1.00
180_Q 266_G 2.39 1.00
36_E 40_A 2.369 1.00
242_M 306_G 2.368 1.00
33_S 36_E 2.307 1.00
237_W 272_I 2.19 0.99
87_P 167_K 2.051 0.99
171_F 281_A 2.027 0.99
49_F 277_A 1.986 0.98
19_P 22_E 1.976 0.98
242_M 308_L 1.929 0.98
235_P 239_N 1.883 0.98
153_M 156_E 1.88 0.98
45_L 132_P 1.869 0.97
67_L 105_L 1.818 0.97
33_S 37_R 1.802 0.97
41_F 170_L 1.787 0.96
49_F 158_I 1.715 0.95
185_E 228_R 1.71 0.95
152_R 156_E 1.628 0.93
240_Q 243_T 1.588 0.92
157_A 161_F 1.587 0.92
90_L 162_T 1.585 0.92
38_I 170_L 1.573 0.91
97_A 101_S 1.57 0.91
47_V 162_T 1.546 0.91
94_C 161_F 1.542 0.90
97_A 161_F 1.524 0.90
295_Y 304_G 1.516 0.89
162_T 171_F 1.485 0.88
102_G 149_Q 1.48 0.88
244_L 252_E 1.44 0.86
89_E 168_R 1.418 0.85
46_V 131_V 1.41 0.84
104_D 150_R 1.4 0.84
36_E 47_V 1.397 0.83
44_E 158_I 1.39 0.83
194_R 197_L 1.343 0.80
241_F 245_L 1.335 0.79
37_R 291_E 1.33 0.79
93_A 164_T 1.269 0.74
179_H 238_D 1.259 0.74
162_T 169_V 1.251 0.73
195_D 228_R 1.25 0.73
90_L 161_F 1.249 0.73
240_Q 252_E 1.235 0.72
26_E 296_R 1.23 0.71
43_P 131_V 1.22 0.70
64_P 106_A 1.22 0.70
98_V 105_L 1.199 0.68
53_H 179_H 1.197 0.68
278_A 288_W 1.182 0.67
240_Q 248_G 1.181 0.67
101_S 171_F 1.18 0.67
46_V 172_L 1.176 0.66
138_I 277_A 1.172 0.66
124_L 128_L 1.168 0.65
36_E 168_R 1.165 0.65
87_P 134_L 1.164 0.65
170_L 278_A 1.163 0.65
3_A 168_R 1.161 0.65
38_I 253_L 1.153 0.64
67_L 160_R 1.144 0.63
162_T 173_G 1.141 0.63
90_L 312_T 1.135 0.62
198_L 204_L 1.132 0.62
148_F 276_V 1.127 0.61
54_Y 68_G 1.116 0.60
128_L 131_V 1.116 0.60
290_S 293_R 1.11 0.60
222_K 229_T 1.106 0.59
270_H 305_F 1.105 0.59
11_S 16_Y 1.103 0.59
240_Q 244_L 1.102 0.59
186_L 194_R 1.101 0.59
194_R 198_L 1.098 0.58
47_V 64_P 1.096 0.58
102_G 105_L 1.095 0.58
213_Q 220_A 1.094 0.58
86_V 135_P 1.092 0.58
85_P 100_K 1.088 0.57
136_V 158_I 1.083 0.57
195_D 202_K 1.083 0.57
75_G 174_S 1.081 0.57
256_V 260_E 1.077 0.56
50_A 117_F 1.065 0.55
67_L 95_A 1.061 0.54
186_L 196_R 1.061 0.54
96_H 259_E 1.058 0.54
49_F 171_F 1.055 0.54
79_S 280_A 1.051 0.53
97_A 164_T 1.051 0.53
97_A 160_R 1.048 0.53
249_R 281_A 1.047 0.53
300_E 305_F 1.042 0.52
62_M 298_I 1.042 0.52
46_V 125_L 1.04 0.52
154_L 158_I 1.038 0.52
32_A 160_R 1.034 0.52
101_S 243_T 1.034 0.52
94_C 251_Q 1.034 0.52
30_V 304_G 1.03 0.51
42_S 168_R 1.029 0.51
200_S 203_D 1.028 0.51
156_E 283_S 1.026 0.51
236_I 253_L 1.025 0.51
90_L 134_L 1.021 0.50
2_H 162_T 1.02 0.50
89_E 261_L 1.019 0.50
302_I 305_F 1.015 0.49
278_A 281_A 1.013 0.49
68_G 135_P 1.013 0.49
57_F 111_M 1.01 0.49
64_P 139_N 1.009 0.49
93_A 97_A 1.008 0.49
8_L 77_F 1.007 0.49
221_E 285_F 1.007 0.49
8_L 31_I 1.005 0.48
47_V 101_S 1.003 0.48
63_P 302_I 1 0.48
193_M 227_Q 1 0.48
243_T 247_Q 1 0.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1b4uB20.84711000.423Contact Map0.535
3vsjA20.82171000.503Contact Map0.416
3vsjB20.85351000.506Contact Map0.503
2pw6A10.78031000.572Contact Map0.402
3bczA40.77391000.631Contact Map0.421
3egcA60.751657.60.957Contact Map0.102
3dbiA30.866256.70.958Contact Map0.113
3k4hA20.754855.90.958Contact Map0.117
3e3mA40.869453.50.958Contact Map0.168
3h5tA10.866253.50.958Contact Map0.088
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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