OPENSEQ.org - CCMD - ECOLI GREMLIN

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CCMD - Heme exporter protein D

UniProt:	P0ABM5	Sequence MTPAFASWNEFFAMGGYAFFVWLAVVMTVIPLVVLVVHSVMQHRAILRGVAQQRAREARLRAAQQQEAA	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG12169
Length:	69 (67)
Sequences:	248
Seq/Len:	3.70

CCMD
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
8_W	12_F	4.06	1.00
19_F	23_L	2.097	1.00
12_F	18_A	1.74	0.99
5_F	56_R	1.64	0.99
53_Q	67_E	1.466	0.97
35_L	39_S	1.45	0.96
58_A	62_A	1.378	0.95
40_V	44_R	1.37	0.94
4_A	53_Q	1.315	0.93
32_L	44_R	1.309	0.93
5_F	35_L	1.306	0.92
25_V	46_I	1.3	0.92
23_L	57_E	1.268	0.91
3_P	6_A	1.262	0.91
30_I	34_V	1.221	0.89
5_F	39_S	1.221	0.89
20_F	49_G	1.214	0.88
10_E	27_M	1.212	0.88
16_G	20_F	1.186	0.87
10_E	13_A	1.175	0.86
23_L	35_L	1.168	0.86
28_T	42_Q	1.161	0.85
15_G	23_L	1.137	0.83
49_G	56_R	1.137	0.83
11_F	15_G	1.129	0.83
26_V	29_V	1.119	0.82
26_V	39_S	1.115	0.82
39_S	46_I	1.087	0.79
24_A	47_L	1.081	0.79
44_R	51_A	1.079	0.79
34_V	58_A	1.066	0.78
52_Q	55_A	1.044	0.75
43_H	51_A	1.038	0.75
5_F	23_L	1.037	0.75
58_A	67_E	1.026	0.74
7_S	13_A	1.02	0.73
37_V	52_Q	1.008	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results:

PDB	Chains	Cov	P(%)	HHΔ		Acc
4i5sA	2	0.8696	10.3	0.899	Contact Map	0.125
1v8kA	1	0.4493	8.6	0.903	Contact Map
4lepA	2	1	7.4	0.906	Contact Map	0.187
4sbvA	3	0.4638	6	0.909	Contact Map
2ww8A	1	0.5942	5.4	0.911	Contact Map	0
2kncB	1	0.8406	5.3	0.912	Contact Map	0.026
4ei7A	2	0.913	3.6	0.918	Contact Map	0.099
3rkoJ	2	0.971	3.3	0.92	Contact Map	0.119
3w4tA	1	0.7826	3.2	0.92	Contact Map	0.123
2l16A	1	0.7681	3.1	0.921	Contact Map	0.222

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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