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OPENSEQ.org
FTSA - Cell division protein FtsA
UniProt: P0ABH0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10339
Length: 420 (377)
Sequences: 3875
Seq/Len: 10.28
FTSA
Paralog alert: 0.67 [within 20: 0.04] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
242_D 299_P 4.563 1.00
125_H 181_K 4.378 1.00
349_Q 355_Q 3.945 1.00
346_A 350_R 3.613 1.00
243_I 288_L 3.428 1.00
104_V 108_D 3.258 1.00
114_H 117_K 2.833 1.00
345_A 358_I 2.824 1.00
231_V 303_E 2.727 1.00
176_E 181_K 2.697 1.00
61_V 97_V 2.682 1.00
209_V 304_L 2.638 1.00
207_C 218_I 2.633 1.00
301_Y 343_G 2.598 1.00
10_V 183_D 2.537 1.00
207_C 220_V 2.479 1.00
292_T 295_E 2.408 1.00
338_A 341_I 2.392 1.00
247_F 286_R 2.389 1.00
220_V 311_E 2.311 1.00
104_V 107_E 2.299 1.00
347_C 350_R 2.275 1.00
211_I 239_V 2.264 1.00
309_N 320_R 2.241 1.00
306_N 309_N 2.213 1.00
243_I 254_A 2.162 1.00
243_I 293_L 2.157 1.00
247_F 254_A 2.137 1.00
305_L 351_V 2.118 1.00
227_R 311_E 2.107 1.00
274_S 285_P 2.105 1.00
102_E 108_D 2.093 1.00
103_E 107_E 2.079 1.00
18_A 213_G 2.041 1.00
348_A 356_V 2.026 1.00
17_T 214_G 1.997 1.00
55_E 86_K 1.955 1.00
346_A 349_Q 1.921 1.00
125_H 183_D 1.917 1.00
325_K 328_L 1.881 1.00
220_V 329_A 1.854 1.00
297_I 341_I 1.836 1.00
204_L 331_G 1.818 1.00
343_G 346_A 1.817 1.00
239_V 297_I 1.812 1.00
306_N 310_E 1.807 1.00
297_I 301_Y 1.799 1.00
240_T 258_K 1.795 1.00
98_P 101_E 1.794 1.00
109_V 147_V 1.78 1.00
205_G 324_V 1.764 1.00
60_C 237_N 1.76 1.00
86_K 98_P 1.743 1.00
293_L 341_I 1.728 1.00
108_D 111_N 1.689 1.00
373_E 376_Y 1.686 1.00
298_E 302_T 1.684 1.00
242_D 300_R 1.665 1.00
242_D 297_I 1.663 1.00
22_A 64_A 1.659 1.00
274_S 287_S 1.65 1.00
244_A 251_P 1.646 1.00
255_E 259_V 1.64 1.00
247_F 288_L 1.616 1.00
256_A 260_R 1.611 1.00
101_E 108_D 1.601 1.00
106_Q 109_V 1.593 1.00
103_E 106_Q 1.586 1.00
58_V 99_I 1.576 1.00
239_V 301_Y 1.561 1.00
241_S 245_Y 1.555 1.00
301_Y 347_C 1.538 1.00
104_V 111_N 1.535 1.00
239_V 300_R 1.528 1.00
106_Q 110_E 1.526 1.00
103_E 108_D 1.508 1.00
112_V 115_T 1.491 1.00
77_S 80_Y 1.473 1.00
289_Q 292_T 1.456 1.00
244_A 254_A 1.451 1.00
88_I 98_P 1.449 1.00
293_L 338_A 1.438 1.00
236_G 258_K 1.433 1.00
246_A 296_V 1.428 1.00
104_V 109_V 1.426 1.00
236_G 338_A 1.421 1.00
310_E 320_R 1.414 1.00
343_G 347_C 1.4 0.99
38_V 41_C 1.4 0.99
302_T 347_C 1.399 0.99
130_V 382_L 1.385 0.99
77_S 81_L 1.378 0.99
340_Q 375_Y 1.375 0.99
198_T 333_V 1.373 0.99
26_E 34_N 1.372 0.99
309_N 351_V 1.357 0.99
309_N 326_H 1.355 0.99
101_E 109_V 1.35 0.99
49_G 53_D 1.345 0.99
310_E 321_Q 1.326 0.99
85_G 95_G 1.325 0.99
169_K 173_K 1.316 0.99
272_D 287_S 1.312 0.99
76_I 79_V 1.306 0.99
331_G 357_R 1.299 0.99
23_L 35_I 1.294 0.99
205_G 330_A 1.277 0.99
91_Q 96_M 1.268 0.99
255_E 258_K 1.252 0.99
59_K 84_S 1.244 0.98
211_I 216_M 1.239 0.98
298_E 343_G 1.237 0.98
83_L 87_H 1.214 0.98
253_D 273_E 1.212 0.98
201_E 204_L 1.208 0.98
58_V 61_V 1.203 0.98
241_S 244_A 1.203 0.98
101_E 104_V 1.197 0.98
11_V 22_A 1.192 0.98
79_V 83_L 1.188 0.98
102_E 107_E 1.187 0.98
253_D 256_A 1.17 0.97
275_V 286_R 1.167 0.97
175_V 182_V 1.166 0.97
23_L 383_L 1.162 0.97
73_D 79_V 1.157 0.97
81_L 85_G 1.151 0.97
107_E 110_E 1.149 0.97
340_Q 373_E 1.143 0.97
305_L 347_C 1.142 0.97
295_E 298_E 1.14 0.97
324_V 328_L 1.133 0.97
39_G 115_T 1.132 0.97
15_I 171_I 1.131 0.97
214_G 217_D 1.122 0.97
229_T 321_Q 1.111 0.96
347_C 351_V 1.109 0.96
319_L 326_H 1.105 0.96
246_A 292_T 1.102 0.96
262_G 297_I 1.099 0.96
233_P 308_V 1.098 0.96
128_L 182_V 1.091 0.96
332_I 352_F 1.087 0.96
204_L 330_A 1.084 0.96
240_T 255_E 1.082 0.96
73_D 76_I 1.076 0.95
75_Q 79_V 1.073 0.95
101_E 106_Q 1.07 0.95
75_Q 233_P 1.069 0.95
75_Q 82_A 1.065 0.95
290_R 342_E 1.058 0.95
25_G 33_V 1.057 0.95
277_V 281_G 1.054 0.95
79_V 82_A 1.048 0.94
78_S 82_A 1.046 0.94
74_C 78_S 1.044 0.94
218_I 229_T 1.04 0.94
292_T 296_V 1.038 0.94
246_A 288_L 1.035 0.94
72_A 89_S 1.033 0.94
72_A 76_I 1.029 0.94
335_T 377_S 1.021 0.93
16_G 212_G 1.018 0.93
68_A 72_A 1.018 0.93
201_E 357_R 1.018 0.93
253_D 257_I 1.015 0.93
357_R 377_S 1.006 0.93
100_S 108_D 1.006 0.93
247_F 284_P 1.006 0.93
10_V 386_G 1.004 0.93
46_M 49_G 1.003 0.93
90_C 96_M 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4a2aA20.96191000.298Contact Map0.447
2d0oA20.85241000.425Contact Map0.315
1nbwA20.84051000.428Contact Map0.309
2ychA10.85711000.433Contact Map0.498
3d2fA20.84291000.538Contact Map0.651
4jneA20.82861000.54Contact Map0.815
1yuwA10.84521000.566Contact Map0.754
4fl9A10.84521000.566Contact Map0.782
2v7yA10.79051000.571Contact Map0.786
3qfuA10.78571000.578Contact Map0.735
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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