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OPENSEQ.org
YEAV - Uncharacterized transporter YeaV
UniProt: P0ABD1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13508
Length: 481 (445)
Sequences: 1480
Seq/Len: 3.33
YEAV
Paralog alert: 0.57 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: BETT CAIT YEAV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
139_L 376_S 3.307 1.00
21_R 26_K 3.295 1.00
214_L 349_F 3.103 1.00
214_L 218_V 2.917 1.00
25_G 282_R 2.844 1.00
118_I 134_V 2.826 1.00
175_A 403_L 2.708 1.00
29_Y 194_N 2.501 1.00
158_T 173_V 2.3 1.00
365_M 398_I 2.258 1.00
172_T 176_F 2.221 1.00
8_L 434_V 2.184 1.00
311_Y 343_L 2.165 1.00
70_S 73_A 2.119 1.00
182_G 399_T 2.086 1.00
187_L 191_I 2.06 1.00
228_I 306_G 2.022 1.00
216_L 307_V 2.006 1.00
33_S 202_K 2 1.00
13_A 291_W 1.984 1.00
379_N 382_E 1.944 1.00
216_L 225_T 1.942 1.00
10_I 14_T 1.939 1.00
15_S 18_G 1.938 1.00
268_S 419_V 1.891 1.00
227_S 310_S 1.875 0.99
122_T 130_W 1.874 0.99
82_F 302_W 1.863 0.99
158_T 177_V 1.863 0.99
128_G 131_G 1.862 0.99
179_L 403_L 1.857 0.99
191_I 199_R 1.84 0.99
158_T 169_D 1.823 0.99
215_V 343_L 1.814 0.99
30_S 33_S 1.808 0.99
316_F 322_N 1.802 0.99
8_L 438_I 1.799 0.99
115_S 132_K 1.795 0.99
188_S 366_D 1.791 0.99
67_A 70_S 1.784 0.99
13_A 290_I 1.776 0.99
363_S 367_A 1.758 0.99
405_I 418_T 1.756 0.99
212_P 307_V 1.748 0.99
428_V 432_V 1.743 0.99
190_W 392_L 1.738 0.99
369_A 395_C 1.738 0.99
170_N 173_V 1.728 0.99
186_C 190_W 1.712 0.99
89_A 266_W 1.683 0.99
208_A 360_F 1.678 0.99
25_G 107_R 1.653 0.98
286_I 441_L 1.646 0.98
11_Y 438_I 1.645 0.98
186_C 395_C 1.642 0.98
176_F 180_L 1.636 0.98
86_G 298_T 1.616 0.98
365_M 369_A 1.613 0.98
56_A 316_F 1.609 0.98
158_T 174_Q 1.605 0.98
338_Q 341_M 1.593 0.98
379_N 383_G 1.592 0.98
206_W 210_L 1.576 0.98
373_A 390_L 1.557 0.97
16_K 19_N 1.549 0.97
396_V 400_L 1.545 0.97
152_V 261_F 1.54 0.97
50_W 53_A 1.533 0.97
59_Y 317_I 1.528 0.97
112_L 115_S 1.524 0.97
43_L 89_A 1.522 0.97
59_Y 69_R 1.514 0.97
358_I 362_A 1.495 0.96
96_A 433_K 1.485 0.96
93_Y 266_W 1.482 0.96
228_I 303_F 1.48 0.96
167_L 173_V 1.474 0.96
29_Y 279_R 1.473 0.96
110_K 119_A 1.465 0.96
36_F 40_C 1.457 0.96
56_A 323_V 1.453 0.96
229_I 233_G 1.453 0.96
200_L 366_D 1.452 0.96
424_L 428_V 1.438 0.95
137_M 429_I 1.435 0.95
99_I 433_K 1.415 0.95
130_W 133_L 1.404 0.94
6_M 10_I 1.402 0.94
340_L 349_F 1.397 0.94
316_F 321_I 1.385 0.94
79_P 238_N 1.378 0.94
31_T 288_E 1.376 0.94
129_P 133_L 1.374 0.93
340_L 353_Y 1.371 0.93
5_A 430_L 1.358 0.93
162_S 169_D 1.356 0.93
12_L 286_I 1.355 0.93
314_H 318_N 1.349 0.93
137_M 422_T 1.349 0.93
203_M 206_W 1.344 0.92
413_E 416_K 1.331 0.92
253_S 257_N 1.328 0.92
66_I 70_S 1.322 0.92
231_A 306_G 1.317 0.91
14_T 291_W 1.314 0.91
122_T 436_G 1.314 0.91
182_G 185_F 1.311 0.91
81_S 305_F 1.305 0.91
119_A 127_Q 1.299 0.91
189_S 395_C 1.296 0.91
161_L 165_T 1.295 0.91
18_G 287_K 1.289 0.90
117_I 433_K 1.288 0.90
154_A 177_V 1.285 0.90
115_S 185_F 1.28 0.90
162_S 168_P 1.275 0.90
40_C 359_I 1.274 0.90
237_Q 241_Q 1.263 0.89
15_S 20_I 1.258 0.89
28_E 282_R 1.257 0.89
369_A 398_I 1.249 0.88
123_G 128_G 1.246 0.88
20_I 441_L 1.243 0.88
21_R 285_K 1.238 0.88
122_T 126_P 1.236 0.88
185_F 395_C 1.234 0.87
119_A 126_P 1.23 0.87
186_C 392_L 1.229 0.87
364_H 367_A 1.22 0.87
98_L 286_I 1.219 0.87
348_L 351_A 1.205 0.86
220_P 224_I 1.203 0.86
183_G 187_L 1.199 0.85
346_G 350_L 1.192 0.85
121_I 435_G 1.191 0.85
168_P 173_V 1.187 0.85
29_Y 37_M 1.186 0.85
173_V 176_F 1.181 0.84
189_S 193_I 1.176 0.84
14_T 287_K 1.176 0.84
171_F 407_F 1.175 0.84
345_A 348_L 1.174 0.84
120_A 123_G 1.165 0.83
329_T 333_E 1.162 0.83
216_L 221_T 1.16 0.83
199_R 203_M 1.159 0.83
33_S 198_Q 1.153 0.82
319_G 322_N 1.147 0.82
228_I 302_W 1.145 0.82
48_L 357_M 1.131 0.80
97_S 102_Y 1.124 0.80
398_I 402_P 1.121 0.80
280_V 433_K 1.119 0.79
6_M 91_A 1.118 0.79
32_L 36_F 1.116 0.79
124_V 127_Q 1.115 0.79
343_L 348_L 1.112 0.79
17_Y 442_K 1.108 0.79
353_Y 357_M 1.108 0.79
158_T 170_N 1.106 0.78
200_L 359_I 1.105 0.78
43_L 47_T 1.103 0.78
171_F 175_A 1.103 0.78
119_A 124_V 1.094 0.77
322_N 325_Q 1.092 0.77
198_Q 202_K 1.091 0.77
87_I 294_I 1.091 0.77
115_S 368_V 1.087 0.77
94_T 293_L 1.085 0.76
306_G 311_Y 1.084 0.76
182_G 361_L 1.078 0.76
203_M 359_I 1.077 0.76
388_R 391_R 1.076 0.76
270_T 430_L 1.075 0.76
190_W 388_R 1.074 0.75
72_Q 75_E 1.074 0.75
230_N 248_P 1.072 0.75
158_T 168_P 1.07 0.75
6_M 95_L 1.069 0.75
52_V 56_A 1.062 0.74
295_L 298_T 1.053 0.73
275_M 374_A 1.051 0.73
378_R 383_G 1.051 0.73
110_K 116_G 1.047 0.73
392_L 396_V 1.046 0.73
43_L 301_C 1.044 0.72
21_R 24_E 1.044 0.72
74_L 317_I 1.041 0.72
146_L 197_L 1.04 0.72
423_A 427_L 1.038 0.72
53_A 254_F 1.038 0.72
59_Y 73_A 1.037 0.72
149_S 153_T 1.034 0.71
195_N 199_R 1.033 0.71
160_G 337_Q 1.029 0.71
220_P 314_H 1.026 0.71
295_L 299_V 1.025 0.71
197_L 367_A 1.025 0.71
9_V 294_I 1.023 0.70
45_S 361_L 1.02 0.70
277_V 293_L 1.02 0.70
365_M 395_C 1.02 0.70
44_G 47_T 1.014 0.69
80_Y 242_M 1.013 0.69
120_A 135_D 1.012 0.69
238_N 242_M 1.009 0.69
259_T 263_W 1.006 0.68
11_Y 14_T 1.004 0.68
243_S 248_P 1.003 0.68
126_P 131_G 1.003 0.68
45_S 153_T 1.002 0.68
123_G 131_G 1.002 0.68
63_G 104_F 1.001 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2wswA10.92521000.071Contact Map0.552
4c7rA30.97711000.082Contact Map0.655
4ainA30.96261000.092Contact Map0.689
3l1lA10.821292.90.966Contact Map0.372
3dh4A40.883690.30.969Contact Map0.39
2xq2A10.904486.80.971Contact Map0.414
3giaA10.779682.80.972Contact Map0.318
2jlnA10.769245.50.979Contact Map0.314
4djkA20.839925.60.981Contact Map0.385
1q90L10.066511.90.984Contact Map0.387
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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