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OPENSEQ.org

END3 - Endonuclease III
UniProt: P0AB83 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10662
Length: 211 (206)
Sequences: 4081
Seq/Len: 19.81

END3
Paralog alert: 0.86 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
107_D 110_A 4.322 1.00
60_T 63_A 3.345 1.00
193_R 196_S 3.071 1.00
95_I 115_P 2.88 1.00
95_I 99_Q 2.823 1.00
188_I 193_R 2.729 1.00
100_H 113_A 2.673 1.00
106_E 132_W 2.665 1.00
57_V 71_G 2.5 1.00
73_K 83_N 2.426 1.00
72_V 90_I 2.278 1.00
12_R 201_D 2.205 1.00
62_A 66_E 2.164 1.00
90_I 94_R 2.132 1.00
37_L 92_T 2.112 1.00
57_V 75_Y 2.091 1.00
99_Q 113_A 2.086 1.00
68_G 71_G 2.074 1.00
59_N 63_A 2.032 1.00
88_N 91_K 2.021 1.00
74_T 77_K 1.968 1.00
94_R 98_E 1.92 1.00
157_E 161_E 1.898 1.00
34_I 89_I 1.816 1.00
108_R 112_E 1.789 1.00
62_A 97_L 1.772 1.00
28_S 31_E 1.765 1.00
12_R 202_L 1.681 1.00
69_V 73_K 1.671 1.00
30_F 93_C 1.64 1.00
142_F 159_V 1.573 1.00
30_F 61_P 1.558 1.00
91_K 115_P 1.557 1.00
67_L 72_V 1.517 1.00
110_A 113_A 1.507 1.00
69_V 90_I 1.505 1.00
53_K 56_P 1.501 1.00
9_I 199_I 1.501 1.00
8_E 12_R 1.493 1.00
18_P 171_F 1.484 1.00
151_A 162_K 1.466 1.00
58_A 75_Y 1.462 1.00
91_K 94_R 1.458 1.00
187_C 197_C 1.455 1.00
52_A 56_P 1.448 1.00
95_I 100_H 1.445 1.00
25_N 52_A 1.441 1.00
27_S 31_E 1.441 1.00
42_A 46_S 1.439 1.00
14_R 174_D 1.438 1.00
39_S 44_D 1.429 1.00
167_V 175_C 1.363 0.99
187_C 194_C 1.334 0.99
103_E 106_E 1.326 0.99
181_L 185_Y 1.317 0.99
64_M 72_V 1.313 0.99
58_A 67_L 1.312 0.99
194_C 203_C 1.297 0.99
33_L 37_L 1.292 0.99
84_S 88_N 1.278 0.99
108_R 126_L 1.236 0.98
96_L 104_V 1.228 0.98
87_E 91_K 1.226 0.98
108_R 134_T 1.226 0.98
46_S 49_K 1.224 0.98
31_E 55_Y 1.224 0.98
97_L 102_G 1.211 0.98
14_R 171_F 1.207 0.98
68_G 90_I 1.191 0.98
84_S 87_E 1.176 0.98
42_A 79_I 1.173 0.98
126_L 132_W 1.172 0.98
119_R 160_E 1.156 0.97
2_N 5_K 1.156 0.97
34_I 55_Y 1.148 0.97
145_C 163_L 1.145 0.97
153_G 159_V 1.131 0.97
106_E 130_F 1.118 0.96
73_K 82_Y 1.102 0.96
17_N 182_H 1.093 0.96
174_D 178_W 1.09 0.96
194_C 197_C 1.089 0.96
131_G 173_V 1.085 0.96
169_A 172_K 1.079 0.95
14_R 178_W 1.061 0.95
16_N 198_I 1.054 0.95
109_A 112_E 1.05 0.94
31_E 59_N 1.048 0.94
61_P 97_L 1.045 0.94
91_K 95_I 1.042 0.94
92_T 114_L 1.032 0.94
171_F 174_D 1.029 0.94
49_K 52_A 1.027 0.94
51_T 55_Y 1.023 0.93
127_N 176_H 1.016 0.93
18_P 174_D 1.01 0.93
70_E 73_K 1.005 0.93
43_T 46_S 1.004 0.93
100_H 110_A 1.002 0.92
147_R 192_P 1.001 0.92
95_I 113_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2abkA111000.153Contact Map0.777
1ornA111000.165Contact Map0.763
3n5nX20.99531000.196Contact Map0.706
3fspA10.99531000.199Contact Map0.654
1kg2A10.9811000.213Contact Map0.729
1keaA111000.221Contact Map0.705
1pu6A20.88631000.327Contact Map0.598
3s6iA20.88631000.45Contact Map0.505
3n0uA30.89571000.456Contact Map0.569
3fhgA10.89571000.464Contact Map0.63

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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