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OPENSEQ.org
YCIM - Uncharacterized protein YciM
UniProt: P0AB58 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12691
Length: 389 (321)
Sequences: 7692
Seq/Len: 23.96
YCIM
Paralog alert: 0.74 [within 20: 0.67] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
333_R 336_E 3.87 1.00
195_D 198_R 3.766 1.00
84_E 87_R 3.764 1.00
229_E 232_K 3.747 1.00
264_K 267_E 3.746 1.00
297_G 300_A 3.654 1.00
122_L 125_R 3.358 1.00
50_Q 53_K 3.326 1.00
156_E 159_K 3.221 1.00
187_A 203_L 2.357 1.00
221_G 237_L 2.349 1.00
76_G 92_H 2.304 1.00
114_G 130_F 2.209 1.00
220_M 236_S 2.034 1.00
323_D 341_L 1.999 1.00
42_G 58_F 1.969 1.00
289_A 305_I 1.945 1.00
148_L 164_A 1.936 1.00
319_H 340_V 1.909 1.00
72_H 91_I 1.844 1.00
204_K 220_M 1.829 1.00
285_E 304_Y 1.827 1.00
306_T 322_M 1.804 1.00
186_L 202_L 1.8 1.00
55_V 75_L 1.794 1.00
288_L 304_Y 1.794 1.00
256_Q 272_L 1.779 1.00
131_N 147_L 1.767 1.00
59_L 75_L 1.759 1.00
110_I 129_M 1.683 1.00
75_L 91_I 1.681 1.00
93_Q 113_L 1.678 1.00
147_L 163_V 1.666 1.00
197_D 227_K 1.66 1.00
322_M 340_V 1.646 1.00
203_L 219_M 1.635 1.00
130_F 146_Q 1.63 1.00
94_T 97_E 1.623 1.00
190_H 198_R 1.611 1.00
58_F 74_T 1.607 1.00
113_L 129_M 1.604 1.00
38_D 57_L 1.592 1.00
273_Q 288_L 1.591 1.00
307_R 310_Q 1.58 1.00
239_R 242_S 1.576 1.00
144_L 163_V 1.569 1.00
45_F 53_K 1.549 1.00
89_I 113_L 1.54 1.00
55_V 78_L 1.508 1.00
165_E 186_L 1.508 1.00
79_F 87_R 1.5 1.00
274_R 277_E 1.489 1.00
238_Q 255_L 1.479 1.00
224_F 232_K 1.465 1.00
205_K 208_A 1.464 1.00
151_Y 159_K 1.462 1.00
127_E 131_N 1.445 1.00
302_Q 322_M 1.442 1.00
255_L 271_F 1.441 1.00
60_D 63_K 1.438 1.00
62_L 71_A 1.435 1.00
106_R 109_A 1.414 1.00
55_V 59_L 1.408 1.00
217_S 236_S 1.403 0.99
252_L 271_F 1.4 0.99
41_A 57_L 1.392 0.99
292_I 300_A 1.389 0.99
200_M 220_M 1.387 0.99
92_H 112_Q 1.38 0.99
200_M 227_K 1.371 0.99
269_A 288_L 1.361 0.99
326_L 336_E 1.342 0.99
52_D 82_R 1.337 0.99
161_I 189_Q 1.335 0.99
234_V 238_Q 1.332 0.99
276_V 285_E 1.332 0.99
272_L 287_M 1.328 0.99
302_Q 306_T 1.322 0.99
234_V 255_L 1.32 0.99
127_E 147_L 1.319 0.99
343_D 346_G 1.316 0.99
255_L 259_Y 1.312 0.99
186_L 190_H 1.306 0.99
113_L 117_Y 1.297 0.99
158_Q 193_S 1.296 0.99
237_L 254_M 1.296 0.99
213_S 216_V 1.289 0.99
234_V 258_C 1.273 0.99
132_Q 135_D 1.264 0.99
231_A 262_L 1.256 0.99
269_A 291_I 1.254 0.99
200_M 223_V 1.253 0.99
117_Y 125_R 1.252 0.99
322_M 326_L 1.249 0.99
259_Y 267_E 1.246 0.98
140_R 143_A 1.245 0.98
127_E 150_I 1.242 0.98
41_A 45_F 1.233 0.98
45_F 50_Q 1.224 0.98
200_M 204_K 1.219 0.98
200_M 224_F 1.219 0.98
315_M 318_F 1.209 0.98
338_L 342_R 1.194 0.98
79_F 84_E 1.193 0.98
133_L 143_A 1.181 0.98
68_T 71_A 1.18 0.98
286_L 321_L 1.177 0.98
117_Y 122_L 1.171 0.98
124_D 154_T 1.162 0.97
288_L 292_I 1.162 0.97
96_M 109_A 1.16 0.97
190_H 195_D 1.159 0.97
62_L 72_H 1.157 0.97
45_F 57_L 1.157 0.97
39_Y 74_T 1.153 0.97
240_V 251_T 1.141 0.97
183_Y 202_L 1.14 0.97
55_V 79_F 1.138 0.97
207_A 216_V 1.133 0.97
266_A 295_R 1.126 0.97
89_I 93_Q 1.125 0.97
207_A 217_S 1.121 0.97
44_N 48_S 1.119 0.96
305_I 321_L 1.119 0.96
161_I 193_S 1.113 0.96
78_L 82_R 1.112 0.96
259_Y 264_K 1.104 0.96
42_G 61_M 1.103 0.96
55_V 82_R 1.1 0.96
234_V 259_Y 1.099 0.96
166_R 169_K 1.096 0.96
86_D 120_A 1.096 0.96
336_E 339_M 1.096 0.96
114_G 133_L 1.091 0.96
116_D 120_A 1.088 0.96
241_I 251_T 1.082 0.96
300_A 303_V 1.079 0.95
224_F 236_S 1.078 0.95
309_L 319_H 1.077 0.95
147_L 151_Y 1.073 0.95
89_I 116_D 1.07 0.95
137_T 140_R 1.069 0.95
151_Y 163_V 1.06 0.95
75_L 79_F 1.059 0.95
302_Q 325_H 1.058 0.95
269_A 273_Q 1.053 0.95
73_L 112_Q 1.048 0.94
267_E 270_E 1.047 0.94
312_H 315_M 1.047 0.94
87_R 90_R 1.046 0.94
134_T 143_A 1.037 0.94
285_E 307_R 1.031 0.94
323_D 344_M 1.028 0.94
79_F 91_I 1.026 0.94
125_R 128_D 1.025 0.93
179_I 182_F 1.019 0.93
161_I 186_L 1.018 0.93
148_L 167_L 1.017 0.93
292_I 297_G 1.016 0.93
53_K 56_D 1.006 0.93
234_V 262_L 1.005 0.93
117_Y 129_M 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1w3bA20.91261000.328Contact Map0.9
2y4tA30.94341000.417Contact Map0.909
3iegA20.8381000.425Contact Map0.896
2xpiA20.90491000.425Contact Map0.822
2gw1A20.88431000.435Contact Map0.822
4horA10.90751000.441Contact Map0.783
3fp2A10.92541000.441Contact Map0.803
4bujB20.96921000.447Contact Map0.851
4g1tA20.88431000.453Contact Map0.729
4kvmA40.96921000.454Contact Map0.833
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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