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OPENSEQ.org

CYSE - Serine acetyltransferase
UniProt: P0A9D4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10187
Length: 273 (266)
Sequences: 399
Seq/Len: 1.50

CYSE
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
171_E 197_R 3.951 1.00
197_R 213_E 3.439 1.00
171_E 198_E 2.76 1.00
142_V 159_A 2.741 1.00
221_G 237_A 2.667 1.00
13_I 102_L 2.546 1.00
156_L 162_I 2.516 1.00
42_G 82_A 2.392 1.00
171_E 213_E 2.369 1.00
213_E 229_P 2.298 0.99
191_D 195_K 2.259 0.99
196_I 214_V 2.242 0.99
172_N 198_E 2.229 0.99
164_V 170_I 2.098 0.99
135_Q 138_V 2.09 0.99
202_I 220_I 2.01 0.98
252_P 256_M 1.943 0.97
195_K 211_N 1.783 0.95
231_P 243_I 1.765 0.95
152_R 172_N 1.761 0.95
201_M 258_Q 1.7 0.93
150_I 164_V 1.695 0.93
18_R 22_D 1.66 0.92
17_A 93_P 1.614 0.91
80_S 83_C 1.591 0.90
118_H 122_N 1.585 0.90
227_L 237_A 1.581 0.90
70_A 119_W 1.57 0.89
141_Q 155_M 1.558 0.89
114_Y 136_V 1.519 0.87
197_R 216_R 1.506 0.86
234_T 243_I 1.457 0.84
114_Y 150_I 1.456 0.84
150_I 170_I 1.453 0.84
156_L 176_I 1.45 0.84
219_K 235_T 1.45 0.84
29_S 38_H 1.443 0.83
24_E 125_R 1.437 0.83
154_I 187_K 1.43 0.82
13_I 99_S 1.428 0.82
156_L 208_I 1.393 0.80
113_A 136_V 1.39 0.80
224_S 227_L 1.367 0.78
42_G 78_I 1.363 0.78
77_M 80_S 1.363 0.78
135_Q 139_T 1.356 0.77
178_Q 229_P 1.348 0.77
197_R 229_P 1.342 0.76
75_P 81_A 1.339 0.76
78_I 81_A 1.332 0.76
121_W 145_H 1.329 0.75
178_Q 197_R 1.329 0.75
30_F 132_L 1.31 0.74
234_T 245_G 1.294 0.73
191_D 211_N 1.293 0.73
217_G 233_H 1.263 0.70
45_L 81_A 1.246 0.69
216_R 233_H 1.245 0.68
9_V 232_P 1.24 0.68
67_V 116_I 1.239 0.68
30_F 104_Y 1.233 0.67
236_A 244_V 1.189 0.63
155_M 201_M 1.187 0.63
14_K 18_R 1.183 0.63
85_I 242_R 1.172 0.62
95_V 105_L 1.17 0.61
153_G 173_D 1.167 0.61
113_A 117_G 1.162 0.61
202_I 208_I 1.157 0.60
111_L 135_Q 1.155 0.60
71_Y 81_A 1.152 0.60
63_I 66_V 1.15 0.59
48_M 221_G 1.149 0.59
9_V 86_Q 1.149 0.59
92_D 106_K 1.148 0.59
52_K 221_G 1.144 0.59
118_H 149_K 1.143 0.59
92_D 186_G 1.143 0.59
230_V 236_A 1.141 0.59
218_A 230_V 1.137 0.58
234_T 244_V 1.129 0.57
177_L 256_M 1.126 0.57
148_A 178_Q 1.126 0.57
71_Y 78_I 1.123 0.57
245_G 252_P 1.114 0.56
7_E 82_A 1.113 0.56
73_A 123_Q 1.113 0.56
252_P 258_Q 1.112 0.56
236_A 242_R 1.104 0.55
161_G 179_S 1.092 0.54
87_A 91_R 1.091 0.53
108_F 114_Y 1.08 0.52
41_L 81_A 1.079 0.52
41_L 108_F 1.077 0.52
47_Y 51_N 1.068 0.51
173_D 198_E 1.068 0.51
23_C 72_A 1.066 0.51
198_E 213_E 1.065 0.51
175_S 256_M 1.059 0.50
106_K 186_G 1.058 0.50
93_P 177_L 1.054 0.50
216_R 232_P 1.052 0.49
77_M 220_I 1.049 0.49
33_A 123_Q 1.042 0.48
13_I 187_K 1.042 0.48
78_I 82_A 1.039 0.48
171_E 216_R 1.033 0.47
69_E 119_W 1.033 0.47
156_L 170_I 1.03 0.47
79_A 152_R 1.029 0.47
117_G 242_R 1.021 0.46
231_P 234_T 1.017 0.46
59_P 130_I 1.015 0.46
40_N 95_V 1.006 0.45
221_G 235_T 1.001 0.44
136_V 142_V 1 0.44
198_E 216_R 1 0.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4n6aA20.98531000.426Contact Map0.545
4h7oA311000.431Contact Map0.624
1ssqA20.9781000.444Contact Map0.586
1t3dA311000.475Contact Map0.602
3mc4A20.9671000.476Contact Map0.63
3q1xA10.98171000.612Contact Map0.531
3f1xA10.92311000.66Contact Map0.53
3tk8A30.871899.90.798Contact Map0.331
3fttA10.655799.80.825Contact Map0.518
1krrA30.666799.80.827Contact Map0.493

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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