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OPENSEQ.org
FTSZ - Cell division protein FtsZ
UniProt: P0A9A6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10347
Length: 383 (319)
Sequences: 1322
Seq/Len: 4.14
FTSZ
Paralog alert: 0.05 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
42_V 60_I 4.476 1.00
78_R 152_E 3.961 1.00
85_R 118_E 3.631 1.00
110_T 149_G 3.63 1.00
18_V 112_A 3.228 1.00
85_R 119_V 3.152 1.00
229_V 305_E 3.07 1.00
118_E 156_H 3.068 1.00
152_E 155_K 2.787 1.00
136_N 166_D 2.776 1.00
234_D 238_E 2.73 1.00
157_V 160_L 2.693 1.00
90_A 93_E 2.655 1.00
133_K 143_M 2.516 1.00
84_D 87_A 2.486 1.00
231_S 305_E 2.485 1.00
129_A 157_V 2.425 1.00
104_M 150_I 2.408 1.00
235_R 274_E 2.352 1.00
31_R 53_A 2.317 1.00
118_E 122_D 2.232 1.00
140_K 144_A 2.113 1.00
262_V 279_G 2.082 1.00
100_I 113_A 2.041 1.00
184_A 187_D 2.041 1.00
129_A 160_L 2.013 1.00
268_F 300_P 1.943 1.00
217_M 313_T 1.88 1.00
42_V 116_V 1.86 1.00
199_L 208_V 1.834 1.00
14_K 95_A 1.812 1.00
238_E 241_E 1.807 1.00
85_R 89_R 1.8 1.00
151_T 155_K 1.794 1.00
89_R 122_D 1.763 0.99
237_E 277_T 1.723 0.99
58_I 91_A 1.716 0.99
79_N 82_D 1.671 0.99
216_V 259_G 1.655 0.99
78_R 82_D 1.645 0.99
26_V 41_A 1.629 0.99
269_D 304_D 1.629 0.99
92_L 123_L 1.572 0.98
119_V 123_L 1.55 0.98
16_I 92_L 1.546 0.98
214_R 218_S 1.545 0.98
40_F 54_V 1.53 0.98
86_D 89_R 1.523 0.98
66_K 96_D 1.514 0.98
58_I 88_L 1.506 0.98
87_A 90_A 1.503 0.98
92_L 98_V 1.503 0.98
89_R 93_E 1.502 0.98
89_R 119_V 1.492 0.98
95_A 98_V 1.487 0.98
231_S 304_D 1.483 0.98
27_E 52_T 1.474 0.97
259_G 287_S 1.463 0.97
180_D 183_G 1.458 0.97
23_G 48_A 1.448 0.97
270_L 306_L 1.443 0.97
266_A 270_L 1.435 0.97
176_I 181_A 1.434 0.97
299_D 307_R 1.426 0.97
30_V 54_V 1.425 0.97
27_E 53_A 1.417 0.96
204_G 297_S 1.413 0.96
144_A 148_Q 1.411 0.96
133_K 147_E 1.401 0.96
187_D 190_K 1.393 0.96
89_R 123_L 1.39 0.96
95_A 125_I 1.369 0.95
258_R 287_S 1.367 0.95
177_S 180_D 1.363 0.95
205_L 296_T 1.356 0.95
275_F 294_I 1.355 0.95
148_Q 152_E 1.352 0.95
159_S 217_M 1.337 0.95
28_H 186_N 1.336 0.95
175_G 273_D 1.329 0.94
152_E 156_H 1.316 0.94
72_A 215_T 1.312 0.94
237_E 241_E 1.3 0.94
81_A 112_A 1.291 0.93
280_N 284_A 1.282 0.93
229_V 307_R 1.264 0.92
75_E 79_N 1.264 0.92
190_K 194_Q 1.256 0.92
133_K 250_E 1.244 0.91
265_T 302_M 1.231 0.91
179_L 298_L 1.229 0.91
25_A 29_M 1.223 0.91
276_E 280_N 1.222 0.91
172_L 184_A 1.218 0.90
41_A 49_L 1.217 0.90
240_A 282_I 1.2 0.89
25_A 39_F 1.194 0.89
14_K 40_F 1.155 0.87
244_I 310_V 1.152 0.87
148_Q 151_T 1.148 0.86
177_S 271_R 1.146 0.86
41_A 54_V 1.145 0.86
100_I 117_A 1.144 0.86
17_G 22_G 1.142 0.86
82_D 118_E 1.14 0.86
62_S 87_A 1.135 0.86
40_F 56_Q 1.118 0.84
133_K 311_V 1.117 0.84
147_E 151_T 1.114 0.84
18_V 116_V 1.114 0.84
129_A 153_L 1.105 0.83
86_D 90_A 1.101 0.83
34_I 190_K 1.098 0.83
196_I 213_V 1.084 0.82
72_A 293_V 1.078 0.81
262_V 308_V 1.077 0.81
278_V 308_V 1.077 0.81
280_N 283_R 1.076 0.81
115_V 118_E 1.073 0.81
172_L 176_I 1.069 0.81
143_M 147_E 1.062 0.80
220_M 227_S 1.062 0.80
286_A 290_A 1.061 0.80
241_E 245_S 1.06 0.80
23_G 41_A 1.053 0.79
167_K 170_K 1.052 0.79
46_A 50_R 1.048 0.79
64_I 311_V 1.035 0.78
14_K 38_E 1.034 0.77
35_E 57_T 1.034 0.77
19_G 22_G 1.017 0.76
60_I 112_A 1.017 0.76
96_D 169_L 1.013 0.75
64_I 79_N 1.01 0.75
269_D 303_N 1.01 0.75
98_V 125_I 1.009 0.75
260_V 286_A 1.006 0.75
123_L 148_Q 1.003 0.74
29_M 196_I 1 0.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vawA10.99741000.239Contact Map0.703
4dxdA10.99481000.265Contact Map0.712
4m8iA10.98961000.274Contact Map0.728
1rq2A20.98171000.291Contact Map0.729
2vxyA10.98691000.291Contact Map0.727
2r75110.88251000.311Contact Map0.743
1ofuA20.83291000.321Contact Map0.78
1w5fA20.88511000.33Contact Map0.784
2vapA10.87991000.334Contact Map0.76
4ei7A20.88511000.397Contact Map0.561
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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