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OPENSEQ.org
F16PA - Fructose-1,6-bisphosphatase class 1
UniProt: P0A993 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10283
Length: 332 (327)
Sequences: 976
Seq/Len: 2.98
F16PA
Paralog alert: 0.07 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
151_N 299_D 4.243 1.00
199_K 317_H 4.212 1.00
151_N 296_R 4.114 1.00
291_S 323_E 3.83 1.00
158_Y 248_H 3.324 1.00
280_A 290_A 3.304 1.00
292_D 295_E 3.13 1.00
148_Q 152_K 2.887 1.00
129_S 153_Q 2.859 1.00
33_A 159_V 2.8 1.00
289_K 320_E 2.792 1.00
243_L 311_F 2.702 1.00
177_A 191_Q 2.615 1.00
36_I 73_L 2.549 1.00
289_K 323_E 2.498 1.00
243_L 247_F 2.466 1.00
289_K 316_D 2.448 1.00
196_F 283_A 2.431 1.00
247_F 313_V 2.409 1.00
73_L 126_T 2.38 1.00
57_V 60_E 2.339 1.00
247_F 283_A 2.317 1.00
170_T 281_F 2.312 1.00
77_L 107_V 2.242 1.00
122_V 240_I 2.175 1.00
198_E 316_D 2.138 1.00
74_K 91_E 2.135 1.00
128_F 157_G 2.123 1.00
83_V 107_V 2.109 1.00
70_N 91_E 2.07 1.00
174_G 285_Q 1.986 1.00
279_M 313_V 1.921 0.99
276_C 311_F 1.91 0.99
179_T 190_C 1.897 0.99
218_K 222_K 1.826 0.99
122_V 242_S 1.807 0.99
198_E 317_H 1.799 0.99
256_I 322_V 1.794 0.99
7_F 176_H 1.792 0.99
91_E 95_V 1.738 0.99
303_E 307_Q 1.695 0.98
213_F 221_I 1.685 0.98
316_D 320_E 1.657 0.98
172_G 285_Q 1.648 0.98
177_A 194_M 1.641 0.98
87_A 305_L 1.636 0.98
85_G 94_I 1.593 0.97
216_G 326_I 1.59 0.97
215_N 219_K 1.574 0.97
203_Y 225_Q 1.567 0.97
204_S 241_G 1.555 0.97
284_E 296_R 1.542 0.96
195_R 198_E 1.53 0.96
177_A 192_E 1.527 0.96
11_K 14_E 1.526 0.96
312_F 319_V 1.506 0.96
170_T 282_L 1.481 0.95
120_V 242_S 1.468 0.95
51_A 61_V 1.427 0.94
300_I 307_Q 1.424 0.94
33_A 187_F 1.421 0.94
243_L 257_Y 1.408 0.93
247_F 311_F 1.392 0.93
297_I 300_I 1.39 0.93
231_T 235_Y 1.373 0.92
281_F 298_L 1.37 0.92
108_L 129_S 1.343 0.91
50_G 64_K 1.338 0.91
320_E 324_R 1.334 0.91
53_G 61_V 1.316 0.90
171_T 176_H 1.311 0.89
55_E 61_V 1.311 0.89
123_S 242_S 1.301 0.89
272_L 277_N 1.291 0.88
292_D 312_F 1.283 0.88
312_F 322_V 1.278 0.88
223_F 325_F 1.277 0.88
272_L 307_Q 1.263 0.87
292_D 300_I 1.241 0.86
258_L 322_V 1.241 0.86
242_S 245_A 1.238 0.86
51_A 63_Q 1.227 0.85
209_N 262_T 1.22 0.84
77_L 83_V 1.217 0.84
74_K 95_V 1.211 0.84
172_G 281_F 1.207 0.84
56_N 59_G 1.204 0.83
203_Y 207_E 1.202 0.83
166_M 177_A 1.2 0.83
208_G 234_P 1.198 0.83
246_D 269_K 1.197 0.83
280_A 297_I 1.185 0.82
217_V 326_I 1.181 0.82
279_M 311_F 1.17 0.81
290_A 296_R 1.166 0.81
201_K 233_R 1.165 0.80
209_N 264_S 1.154 0.80
170_T 285_Q 1.153 0.79
149_P 301_I 1.153 0.79
124_V 291_S 1.147 0.79
223_F 321_D 1.145 0.79
37_H 165_T 1.141 0.78
202_T 253_K 1.133 0.78
271_R 275_E 1.128 0.77
70_N 74_K 1.122 0.77
116_S 127_I 1.121 0.77
321_D 324_R 1.112 0.76
296_R 299_D 1.111 0.76
66_D 90_E 1.109 0.76
207_E 225_Q 1.106 0.75
319_V 322_V 1.096 0.74
89_E 115_S 1.094 0.74
85_G 146_F 1.091 0.74
241_G 246_D 1.09 0.74
258_L 312_F 1.089 0.74
243_L 283_A 1.088 0.74
261_S 265_H 1.086 0.74
62_Q 67_L 1.086 0.74
93_E 143_E 1.086 0.74
85_G 106_V 1.084 0.73
7_F 178_F 1.083 0.73
62_Q 318_M 1.081 0.73
59_G 62_Q 1.08 0.73
205_I 258_L 1.078 0.73
4_L 30_K 1.077 0.73
200_G 315_N 1.067 0.72
66_D 89_E 1.062 0.71
227_E 234_P 1.058 0.71
276_C 297_I 1.058 0.71
324_R 328_E 1.057 0.71
37_H 180_Y 1.052 0.70
191_Q 252_L 1.051 0.70
151_N 298_L 1.05 0.70
73_L 109_M 1.048 0.70
259_Y 268_G 1.046 0.69
12_Q 23_T 1.041 0.69
20_G 23_T 1.025 0.67
33_A 68_F 1.022 0.67
215_N 218_K 1.019 0.67
194_M 252_L 1.018 0.66
219_K 328_E 1.016 0.66
166_M 191_Q 1.016 0.66
281_F 293_G 1.015 0.66
219_K 222_K 1.014 0.66
31_L 186_V 1.013 0.66
205_I 221_I 1.009 0.65
174_G 178_F 1.004 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1dcuA40.97891000.35Contact Map0.669
2fhyA40.98491000.385Contact Map0.784
2gq1A111000.417Contact Map0.773
1nuwA10.98491000.442Contact Map0.787
3uksA20.93671000.469Contact Map0.673
1lbvA20.74799.90.812Contact Map0.375
2bjiA20.804299.90.812Contact Map0.334
4g62A20.771199.90.812Contact Map0.485
4i3yA20.789299.90.817Contact Map0.472
1xi6A10.780199.90.817Contact Map0.386
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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